Abstract:
:The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain function, as the abnormal regulation of GluN2A may induce some neuropsychiatric disorders. This review will examine the regulation of GluN2A by endogenous and exogenous regulators in the central nervous system.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Sun Y,Zhan L,Cheng X,Zhang L,Hu J,Gao Zdoi
10.1007/s10571-016-0388-6subject
Has Abstractpub_date
2017-04-01 00:00:00pages
389-403issue
3eissn
0272-4340issn
1573-6830pii
10.1007/s10571-016-0388-6journal_volume
37pub_type
杂志文章,评审abstract::Agmatine is an endogenous amine that is synthesized following the decarboxylation of L-arginine by arginine decarboxylase. Agmatine exists in mammalian brain and has been proposed as a neurotransmitter and/or neurotransmodulator. Agmatine binds to several targets and is considered as an endogenous ligand for imidazoli...
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