Abstract：
:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate of the synthesis of Tau protein during the period of granule cell axonal growth in mouse cerebellum. 2. We found four [35S]methionine-labeled isoforms of Tau synthesized postnataly. Their levels remain constant from postnatal day 9 to 12 (P9-P12), and decreased by P20. 3. The rate of Tau synthesis showed differences with the rate of synthesis of total proteins. They also differ from proteins phosphatases 2A and 2B, both associated with the regulation of Tau function. In addition, the turnover of newly synthesized Tau increased at P20, compared with P9 and P12. 4. These results imply a specific developmental regulation of mRNA translation of Tau, and indicate that, after the period of synapse formation is complete, and therefore axonal growth has finished (P20), only a limited number of new Tau molecules are synthesized. This might reflect that, after synapse formation is complete, newly synthesized Tau molecules are not longer needed.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Vilá-Ortiz GJ,Santa-Coloma TA,Carminatti H,Radrizzani Mdoi
10.1023/a:1013823524302subject
Has Abstractpub_date
2001-10-01 00:00:00pages
535-43issue
5eissn
0272-4340issn
1573-6830journal_volume
21pub_type
杂志文章abstract：:ERK pathway plays a critical role in the cellular adaptive responses to environmental changes. Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect. In this study, we investigated the effects of morphine-ind...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-0011-z
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
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pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
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更新日期：2015-08-01 00:00:00
