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Altered expression of the prion gene in rat astrocyte and neuron cultures treated with prion peptide 106-126.

Abstract：

:Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated. To further elucidate the involvement of PrPC in PrP106-126-induced neurotoxicity, we determined the expression of PrP mRNA in primary culture of rat cortical neuron cells, cerebellar granule cells, and astrocytes following treatment with 50 microM of PrP106-126 scrambled PrP106-126 by quantitative real-time RT-PCR. As shown by MTT test, PrP106-126 induced significant death of neuron cells and marked proliferation of astrocytes after 10 days of treatment. Under the same treatment regimens, the level of PrP gene expression was significantly down-regulated in cortical neuron cell cultures and cerebellar granule cell cultures and was up-regulated in astrocyte cultures. The altered PrP gene expression occurred as early as 3 days after the treatment. After 10 days of treatment, while the cultured cortical neurons underwent further apoptosis, their expression of PrP gene started to recover gradually. These findings indicate that PrP 106-126 regulates transcription of the PrP gene and this activity is associated with its neurotoxicity in primary rat neuronal cultures.

journal_name

Cell Mol Neurobiol

journal_title

Cellular and molecular neurobiology

authors

Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

doi

10.1007/s10571-005-8357-5

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1171-83

issue

8

eissn

0272-4340

issn

1573-6830

journal_volume

25

pub_type

杂志文章

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