Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease.

abstract：:In this study, we investigated the actions of high homocysteine (Hcy) levels (100 and 500 microM) on the cytoskeleton of C6 glioma cells. Results showed that the predominant cytoskeletal response was massive formation of actin-containing filopodia at the cell surface that could be related with Cdc42 activation and inc...

journal_title：Cellular and molecular neurobiology

authors： Loureiro SO,Heimfarth L,Lacerda BA,Vidal LF,Soska A,dos Santos NG,de Souza Wyse AT,Pessoa-Pureur R

更新日期：2010-05-01 00:00:00

abstract：:Both sex and steroid hormones are important to consider in human ischemic stroke and its experimental models. Stroke initiates a cascade of changes that lead to neural cell death, but also activates endogenous protective processes that counter the deleterious consequences of ischemia. Steroids may be part of these cer...

journal_title：Cellular and molecular neurobiology

authors： Guennoun R,Zhu X,Fréchou M,Gaignard P,Slama A,Liere P,Schumacher M

更新日期：2019-05-01 00:00:00

abstract：:1. A lambda phage genomic DNA library for Limulus (L.) polyphemus brain was constructed using the AGEM-12 vector and the host strain KW251. 2. The primary library contained approximately 1.275 x 10(6) independent clones, increasing upon amplfication to 6.66 x 10(9) pfu/ml in a total volume of 58 ml. 3. A total of 28 c...

journal_title：Cellular and molecular neurobiology

authors： Wang Y,Cao Z,Reid EA,Newkirk RF,Ivy MT,Townsel JG

更新日期：2000-08-01 00:00:00

abstract：:Oxidative stress is one of the mechanisms implicated to play a significant role in the pathophysiology of Parkinson's disease. Previously, we showed that an aqueous extract of Selaginella delicatula (SDAE) offered robust neuroprotection against rotenone (ROT) in a Drosophila model. In furtherance in the present study,...

journal_title：Cellular and molecular neurobiology

authors： Chandran G,Muralidhara

更新日期：2013-10-01 00:00:00

abstract：:Endothelins have been implicated in the regulation of cell proliferation, differentiation, and apoptosis, but the mechanisms of these complex events are not yet fully understood. Although the nuclear factor-kappaB (NF-kappaB) was shown to play a prominent role in the above processes, its participation in endothelin re...

journal_title：Cellular and molecular neurobiology

authors： Mangelus M,Galron R,Naor Z,Sokolovsky M

更新日期：2001-12-01 00:00:00

abstract：:Cathepsin K deficiency in male mice (Ctsk-/-) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because T...

journal_title：Cellular and molecular neurobiology

authors： Dauth S,Rakov H,Sîrbulescu RF,Ilieş I,Weber J,Batbajar Dugershaw B,Braun D,Rehders M,Wirth EK,Führer D,Schweizer U,Brix K

更新日期：2020-07-01 00:00:00

abstract：:Somatostatin which is a multifunctional growth hormone inhibitory neuropeptide shows diverse physiological effects, such as neurotransmission, cell growth, apoptosis, and endocrine signaling as well as exerts inhibitory effects on hormonal products and other secretory proteins. SSTR3 is a member of superfamily of soma...

journal_title：Cellular and molecular neurobiology

authors： Yao Q,Liu Q,Xu H,Wu Z,Zhou L,Gu Z,Gong P,Shen J

更新日期：2017-11-01 00:00:00

abstract：:1. Growth cones of cultured dorsal root ganglion neurons from mice were irradiated using a mercury lamp. 2. The flux of particles of fast retrograde axoplasmic transport decreased promptly after light irradiation without a change in velocity. 3. That of anterograde transport decreased as well, but with a significant l...

journal_title：Cellular and molecular neurobiology

authors： Kano M,Tashiro H,Kawakami T,Takenaka T,Gotoh H

更新日期：1995-06-01 00:00:00

abstract：:Ubiquitination of proteins and their degradation within the proteasome has emerged as the major proteolytic mechanism used by mammalian cells to regulate cytosolic and nuclear protein levels. Substrate ubiquitylation is mediated by ubiquitin (Ub) ligases, also called E3 Ub ligases. HECT-E3 Ub ligases are characterized...

journal_title：Cellular and molecular neurobiology

authors： Zhang L,Kang L,Bond W,Zhang N

更新日期：2009-02-01 00:00:00

abstract：:Shengmai (SM) formula, a classical traditional Chinese medicine formula, is composed of Panax ginseng (Pg), Ophiopogon japonicus (Oj), and Schisandra Chinesis (Sc). SM has been clinically used to treat heart failure and ischemic heart disease. Although SM formula has been reported to be potential for fighting against ...

journal_title：Cellular and molecular neurobiology

authors： Zhang W,Zhi D,Ren H,Wang D,Wang X,Zhang Z,Fei D,Zhu H,Li H

更新日期：2016-11-01 00:00:00

abstract：:1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

journal_title：Cellular and molecular neurobiology

authors： Platt B,Büsselberg D

更新日期：1994-12-01 00:00:00

abstract：:1. The analogies between the processing of amyloid precursor protein (APP) and other transmembrane sterol regulatory element binding proteins (SREBPs) inspired us to conduct further studies on whether beta-amyloid (Abeta) affects aromatase by interacting with APP and SREBP. 2. In this study, cultured human neuroblasto...

journal_title：Cellular and molecular neurobiology

authors： Kelicen P,Nordberg A

更新日期：2006-05-01 00:00:00

abstract：:1. The aim of the present study is to map the incipient phase of Fos expression in the sacral spinal cord neuronal pools of multiple cauda equina constrictions canine model. 2. Fos-positive neurons were found bilaterally in the lateral portion of superficial dorsal horn layers (Laminae I-III) and along the lateral edg...

journal_title：Cellular and molecular neurobiology

authors： Orendácová J,Marsala M,Cízková D,Kafka J,Raceková E,Sulla I,Vanický I,Marsala J

更新日期：2001-08-01 00:00:00

abstract：:(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for these effects are unknown. (2) The present study analyzed morphological changes in motoneurons distal to the lesion site from rats with or without progesterone t...

journal_title：Cellular and molecular neurobiology

authors： González SL,López-Costa JJ,Labombarda F,González Deniselle MC,Guennoun R,Schumacher M,De Nicola AF

更新日期：2009-02-01 00:00:00

abstract：:Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms underlying the increased iron are still unknown. Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1)...

journal_title：Cellular and molecular neurobiology

authors： Wang J,Bi M,Xie J

更新日期：2015-07-01 00:00:00

abstract：:1. The visual transduction system of the vertebrate retina is a well-studied model for biochemical and molecular studies of signal transduction. The structure and function of rhodopsin, a prototypical G protein-coupled receptor, and transducin or Gt, the photoreceptor G protein, have been particularly well studied. Me...

journal_title：Cellular and molecular neurobiology

authors： Hamm HE

更新日期：1991-12-01 00:00:00

abstract：:1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional ...

journal_title：Cellular and molecular neurobiology

authors： Vega-Hernández A,Felix R

更新日期：2002-04-01 00:00:00

abstract：:One of the few areas of the adult CNS, that are known to be competent for neuronal proliferation, is the subventricular zone (SVZ) lining the brain lateral ventricles. Cells proliferating in the SVZ migrate along a defined pathway, the rostral migratory stream (RMS), where their proliferation continues until reaching ...

journal_title：Cellular and molecular neurobiology

authors： Bálentová S,Raceková E,Martoncíková M,Misúrová E

更新日期：2006-10-01 00:00:00

abstract：:The original version of this article unfortunately contained a typo in co-author name. ...

journal_title：Cellular and molecular neurobiology

authors： Narayan A,Hunkele A,Xu J,Bassoni DL,Pasternak GW,Pan YX

更新日期：2020-10-31 00:00:00

abstract：:Glioblastoma Multiforme (GBM) is an aggressive form of brain Tumor that has few cures. In this study, we analyze the anti-proliferative effects of a new molecule JQ1 against GBMs induced in Wistar Rats. JQ1 is essentially a Myc inhibitor. c-Myc is also known for altering the biochemistry of a tumor cell. Therefore, th...

journal_title：Cellular and molecular neurobiology

authors： Rajagopalan V,Vaidyanathan M,Janardhanam VA,Bradner JE

更新日期：2014-10-01 00:00:00

abstract：:1. Accumulation of different c-erbA transcripts was studied, during rat brain maturation and in cortical neurons differentiating in a serum-free medium, by quantitative Northern blot hybridization. 2. The alpha and beta forms of c-erbA mRNAs exhibit different patterns of accumulation, with a precocious increase in the...

journal_title：Cellular and molecular neurobiology

authors： Castiglia D,Cestelli A,Di Liegro C,Bonfanti L,Di Liegro I

更新日期：1992-06-01 00:00:00

abstract：:1. Transient forebrain ischemia in adult rats, induced by 10 min of bilateral carotid occlusion and an arterial hypotension of 40 mmHg, caused substantial damage not only to CA-1 neurons in hippocampus but also to epithelial cells in lateral ventricle choroid plexus. 2. When transient forebrain ischemia was followed b...

journal_title：Cellular and molecular neurobiology

authors： Johanson CE,Palm DE,Primiano MJ,McMillan PN,Chan P,Knuckey NW,Stopa EG

更新日期：2000-04-01 00:00:00

abstract：:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML...

journal_title：Cellular and molecular neurobiology

authors： Harthoorn LF

更新日期：2007-02-01 00:00:00

abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...

journal_title：Cellular and molecular neurobiology

authors： Foley TD,Clark AR,Stredny ES,Wierbowski BM

更新日期：2012-03-01 00:00:00

abstract：:Since gonadal female hormones act on and protect neurons, it is well known that the female brain is less vulnerable to stroke or other brain insults than the male brain. Although glial functions have been shown to affect the vulnerability of the brain, little is known if such a sex difference exists in glia, much less...

journal_title：Cellular and molecular neurobiology

authors： Morizawa Y,Sato K,Takaki J,Kawasaki A,Shibata K,Suzuki T,Ohta S,Koizumi S

更新日期：2012-08-01 00:00:00

abstract：:We have previously demonstrated that alpha2-adrenoceptors regulate hypothalamic magnocellular oxytocinergic (OXY) neurons in Sprague Dawley rats. Here we investigated whether activation/inhibition of alpha2-adrenoceptors may similarly trigger/downregulate the activity of OXY neurons in control Long Evans (+/+) and per...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2009-09-01 00:00:00

abstract：:The inhibitory effects of various opiates on developing rat vas deferens were studied by determining the degree of depression of mechanical responses elicited by electrical field stimulation. All agonists showed decreased effects with maturation, but the decrease occurred at different times. With normorphine the loss ...

journal_title：Cellular and molecular neurobiology

authors： Rónai AZ,Berzétei IP,Kurgyis J

更新日期：1981-12-01 00:00:00

abstract：:This study tested whether the glial cells are involved in the exciting effects of doxapram on brainstem slice in vitro. Experiments were performed in brainstem slice preparations from neonatal rats. The medial area of nucleus retrofacialis (mNRF) and the hypoglossal nerve (XII nerve) were contained in the preparations...

journal_title：Cellular and molecular neurobiology

authors： Li GC,Zhang HT,Jiao YG,Wu ZH,Fang F,Cheng J

更新日期：2010-07-01 00:00:00

abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

journal_title：Cellular and molecular neurobiology

authors： Spencer GE,Lukowiak K,Syed NI

更新日期：1996-10-01 00:00:00

abstract：:1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

journal_title：Cellular and molecular neurobiology

authors： Meinertzhagen IA,Hu X

更新日期：1996-12-01 00:00:00