Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: histochemical evidence.

abstract：:1. Five drugs with the predominant pharmacologic effect of inhibiting the neuronal reuptake of serotonin are available worldwide for clinical use. This class of psychoactive drugs, known as selective serotonin reuptake inhibitors (SSRIs), is comprised of fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram....

journal_title：Cellular and molecular neurobiology

authors： DeVane CL

更新日期：1999-08-01 00:00:00

abstract：:We investigated the postnatal alterations of neurons, astrocyte, oligodendrocyte, and microglia in the mouse hippocampal CA1 sector and dentate gyrus under the same conditions using immunohistochemistry. Neuronal nuclei (NeuN), Glial fibrillary acidic protein (GFAP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPas...

journal_title：Cellular and molecular neurobiology

authors： Kimoto H,Eto R,Abe M,Kato H,Araki T

更新日期：2009-12-01 00:00:00

abstract：:Reeler heterozygous mice (reln+/-) are seemingly normal but haplodeficient in reln, a gene implicated in autism. Structural/neurochemical alterations in the reln+/- brain are subtle and difficult to demonstrate. Therefore, the usefulness of these mice in translational research is still debated. As evidence implicated ...

journal_title：Cellular and molecular neurobiology

authors： Castagna C,Merighi A,Lossi L

更新日期：2019-08-01 00:00:00

abstract：:The analgesia effects of intrathecal adenosine A1 receptor agonist, R-PIA, on the hyperalgesia and CSF-glutamate release after formalin injection into the rat paw were evaluated. R-PIA significantly and dose-dependently attenuated increases in flinching behavior, and this attenuating effect was reversed by the adenosi...

journal_title：Cellular and molecular neurobiology

authors： Yamamoto S,Nakanishi O,Matsui T,Shinohara N,Kinoshita H,Lambert C,Ishikawa T

更新日期：2003-04-01 00:00:00

abstract：:GABA is an inhibitory neurotransmitter that appears to be associated with the action of volatile anesthetics. These anesthetics potentiate GABA-induced postsynaptic currents by synaptic GABAA receptors, although recent evidence suggests that these agents also significantly affect extrasynaptic GABA receptors. However,...

journal_title：Cellular and molecular neurobiology

authors： Diniz PH,Guatimosim C,Binda NS,Costa FL,Gomez MV,Gomez RS

更新日期：2014-01-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

journal_title：Cellular and molecular neurobiology

authors： Schorderet M,Nowak JZ

更新日期：1990-09-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

journal_title：Cellular and molecular neurobiology

authors： Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

更新日期：2020-10-30 00:00:00

abstract：:Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction...

journal_title：Cellular and molecular neurobiology

authors： Shtark MB,Gainutdinov KL,Khichenko VI,Starostina MV

更新日期：1981-09-01 00:00:00

abstract：:(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for these effects are unknown. (2) The present study analyzed morphological changes in motoneurons distal to the lesion site from rats with or without progesterone t...

journal_title：Cellular and molecular neurobiology

authors： González SL,López-Costa JJ,Labombarda F,González Deniselle MC,Guennoun R,Schumacher M,De Nicola AF

更新日期：2009-02-01 00:00:00

abstract：:The hypothesis that peripheral, skeletal muscle tissue contains a trophic factor supporting central neurons has recently been investigated in vitro by supplementing the culture medium of spinal cord neurons with muscle extracts and fractions of extract. We extended these studies asking whether or not a trophic factor ...

journal_title：Cellular and molecular neurobiology

authors： Popiela H,Porter T,Beach RL,Festoff BW

更新日期：1984-03-01 00:00:00

abstract：:In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the...

journal_title：Cellular and molecular neurobiology

authors： Yan BC,Park JH,Kim SK,Choi JH,Lee CH,Yoo KY,Kwon YG,Kim YM,Kim JD,Won MH

更新日期：2012-11-01 00:00:00

abstract：:In chromaffin cells, SNARE proteins, forming the basic exocytotic machinery are present in membrane clusters of 500-600 nm in diameter. These microdomains containing both SNAP-25 and syntaxin-1 are dynamic and the expression of altered forms of SNAREs modifies not only their motion but also the mobility of the associa...

journal_title：Cellular and molecular neurobiology

authors： Torregrosa-Hetland CJ,Villanueva J,López-Font I,Garcia-Martinez V,Gil A,Gonzalez-Vélez V,Segura J,Viniegra S,Gutiérrez LM

更新日期：2010-11-01 00:00:00

abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

journal_title：Cellular and molecular neurobiology

authors： Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

更新日期：2004-06-01 00:00:00

abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...

journal_title：Cellular and molecular neurobiology

authors： Foley TD,Clark AR,Stredny ES,Wierbowski BM

更新日期：2012-03-01 00:00:00

abstract：:Cerebral cavernous malformations (CCM) are vascular malformations associated with abnormally dilated blood vessels and leaky capillaries that often result in hemorrhages. Despite recent advances, precise understanding of the cellular and molecular mechanism leading to the pathogenesis of CCM remains elusive. Emerging ...

journal_title：Cellular and molecular neurobiology

authors： Kar S,Bali KK,Baisantry A,Geffers R,Hartmann C,Samii A,Bertalanffy H

更新日期：2018-10-01 00:00:00

abstract：:1. The growth inhibitory factor (GIF) is a 68-amino acid protein which is capable of inhibiting the growth of neuronal cells in vitro. 2. We have cloned and sequenced the 5'-flanking region of the mouse GIF gene, which spans from the transcriptional initiation site to the -1854 nucleotide. 3. This region contains sequ...

journal_title：Cellular and molecular neurobiology

authors： Watabe M,Gross S,Lawyer C,Brewer GJ,Mashimo T,Watabe K

更新日期：1997-04-01 00:00:00

abstract：:Neuroinflammation has become an important underlying factor in many cardiovascular disorders, including hypertension. Previously we showed that elevated angiotensin II (Ang II) and angiotensin II type I receptor (AT1R) expression levels can increase neuroinflammation leading to hypertension. We also found that kinin B...

journal_title：Cellular and molecular neurobiology

authors： Parekh RU,Robidoux J,Sriramula S

更新日期：2020-07-01 00:00:00

abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

journal_title：Cellular and molecular neurobiology

authors： Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

更新日期：1998-06-01 00:00:00

abstract：:1. Gamma-aminobutryic acid (GABA), a major inhibitory transmitter of the vertebrate retina, is synthesized from glutamate by L-glutamate decarboxylase (GAD) and mediates neuronal inhibition at GABAA receptors. GAD consists of two distinct molecular forms, GAD65 and GAD67, which have similar distribution patterns in th...

journal_title：Cellular and molecular neurobiology

authors： Brecha NC,Sternini C,Humphrey MF

更新日期：1991-10-01 00:00:00

abstract：:The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immedia...

journal_title：Cellular and molecular neurobiology

authors： Myers B,McKlveen JM,Herman JP

更新日期：2012-02-01 00:00:00

abstract：:Podoplanin (PDPN) is a mucin-type transmembrane sialoglycoprotein expressed in multiple tissues in adult animals, including the brain, lungs, kidney, and lymphoid organs. Studies of this molecule have demonstrated its great importance in tumor metastasis, platelet aggregation, and lymphatic vessel formation. However, ...

journal_title：Cellular and molecular neurobiology

authors： Song Y,Shen J,Lin Y,Shen J,Wu X,Yan Y,Zhou L,Zhang H,Zhou Y,Cao M,Liu Y

更新日期：2014-08-01 00:00:00

abstract：:Abeta accumulation, a hallmark of Alzheimer's disease, promotes the disease progress in multiple facets. Abeta is formed through amyloidogenic cleavage pathway of amyloid precursor protein (APP). Production of Abeta can be decreased via activation of 5-HT2C receptor, which enhances alternative APP non-amyloidogenic cl...

journal_title：Cellular and molecular neurobiology

authors： Tian XL,Yu LH,Li WQ,Hu Y,Yin M,Wang ZJ

更新日期：2015-04-01 00:00:00

abstract：:Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceabl...

journal_title：Cellular and molecular neurobiology

authors： Kontro P,Oja SS

更新日期：1983-06-01 00:00:00

abstract：:Glycoproteins of the extracellular matrix (ECM) regulate proliferation, migration, and differentiation in numerous cell lineages. ECM functions are initiated by small peptide sequences embedded in large constituents that are recognized by specific cellular receptors. In this study, we have investigated the biological ...

journal_title：Cellular and molecular neurobiology

authors： Brösicke N,Sallouh M,Prior LM,Job A,Weberskirch R,Faissner A

更新日期：2015-07-01 00:00:00

abstract：:Cannabinoid (CB) ligands have demonstrated neuroprotective properties. In this study we compared the effects of a diverse set of CB ligands against β amyloid-mediated neuronal toxicity and activated microglial-conditioned media-based neurotoxicity in vitro, and compared this with a capacity to directly alter β amyloid...

journal_title：Cellular and molecular neurobiology

authors： Janefjord E,Mååg JL,Harvey BS,Smid SD

更新日期：2014-01-01 00:00:00

abstract：:Glioma stem cells (GSCs) are thought to be critical for resistance to radiotherapy and chemotherapy and for tumor recurrence after surgery in glioma patients. Identification of new therapeutic strategies that can target GSCs may thus be critical for improving patient survival. MicroRNAs (miRNAs) are small non-coding R...

journal_title：Cellular and molecular neurobiology

authors： Chen L,Chen XR,Chen FF,Liu Y,Li P,Zhang R,Yan K,Yi YJ,Xu ZM,Jiang XD

更新日期：2013-07-01 00:00:00

abstract：:1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine...

journal_title：Cellular and molecular neurobiology

authors： Stefano GB,Sawada M,Smith EM,Hughes TK

更新日期：1993-12-01 00:00:00

abstract：:Fractalkine (CX3CL1) is a potent inflammatory mediator of the central nervous system, which is expressed by neurons and regulates microglial functions by binding to fractalkine receptor (CX3CR1). It has been demonstrated that neuroinflammation plays an important role in iron accumulation of the brain leading to neuron...

journal_title：Cellular and molecular neurobiology

authors： Pandur E,Tamási K,Pap R,Varga E,Miseta A,Sipos K

更新日期：2019-10-01 00:00:00

abstract：:The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both es...

journal_title：Cellular and molecular neurobiology

authors： Singh S,Thakur MK

更新日期：2011-04-01 00:00:00