Gonadal steroids do not affect apolipoprotein E expression in aging mouse cerebral cortex.

Abstract:

:The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both estrogen and testosterone have beneficial effects on brain due to interaction with apoE, but the underlying mechanism is still not clear. In this article, we report the effects of gonadectomy and hormone supplementation on apoE protein level in male and female mouse cerebral cortex during normal aging. We could not get any effect of gonadectomy and estradiol or testosterone treatment in adult and old mice of either sex. This suggests that during normal aging apoE protein level is not affected due to steroid hormone withdrawal or supplementation in the mouse cerebral cortex.

journal_name

Cell Mol Neurobiol

authors

Singh S,Thakur MK

doi

10.1007/s10571-010-9631-8

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

401-5

issue

3

eissn

0272-4340

issn

1573-6830

journal_volume

31

pub_type

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