Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.

abstract：:ERK pathway plays a critical role in the cellular adaptive responses to environmental changes. Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect. In this study, we investigated the effects of morphine-ind...

journal_title：Cellular and molecular neurobiology

authors： Haghparast A,Fatahi Z,Alamdary SZ,Reisi Z,Khodagholi F

更新日期：2014-03-01 00:00:00

abstract：:The inhibitory effects of various opiates on developing rat vas deferens were studied by determining the degree of depression of mechanical responses elicited by electrical field stimulation. All agonists showed decreased effects with maturation, but the decrease occurred at different times. With normorphine the loss ...

journal_title：Cellular and molecular neurobiology

authors： Rónai AZ,Berzétei IP,Kurgyis J

更新日期：1981-12-01 00:00:00

abstract：:The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both es...

journal_title：Cellular and molecular neurobiology

authors： Singh S,Thakur MK

更新日期：2011-04-01 00:00:00

abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

journal_title：Cellular and molecular neurobiology

authors： Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

更新日期：2004-06-01 00:00:00

abstract：:Inhibitory mechanism of cerebellum epileptic activity can be involved depending on the intensity and frequency of seizure convulsions. N-methyl-D-aspartate receptors (NMDARs) play key roles in excitatory synaptic transmission and have been implicated in neurological disorders: in cerebellum, they have specific charact...

journal_title：Cellular and molecular neurobiology

authors： Girardi E,Auzmendi J,Charó N,Gori MB,Castro M

更新日期：2010-10-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are considered a promising tool for cell-based therapies of nervous system diseases. Bone marrow (BM) has been the traditional source of MSCs (BM-MSCs). However, there are some limitations for their clinical use, such as the decline in cell number and differentiation potential with ...

journal_title：Cellular and molecular neurobiology

authors： Yan ZJ,Hu YQ,Zhang HT,Zhang P,Xiao ZY,Sun XL,Cai YQ,Hu CC,Xu RX

更新日期：2013-05-01 00:00:00

abstract：:Repeated electrical stimulation results in development of seizures and a permanent increase in seizure susceptibility (kindling). The permanence of kindling suggests that chronic changes in gene expression are involved. Kindling at different sites produces specific effects on interictal behaviors such as spatial cogni...

journal_title：Cellular and molecular neurobiology

authors： Corcoran ME,Kroes RA,Burgdorf JS,Moskal JR

更新日期：2011-08-01 00:00:00

abstract：:1. Accumulation of different c-erbA transcripts was studied, during rat brain maturation and in cortical neurons differentiating in a serum-free medium, by quantitative Northern blot hybridization. 2. The alpha and beta forms of c-erbA mRNAs exhibit different patterns of accumulation, with a precocious increase in the...

journal_title：Cellular and molecular neurobiology

authors： Castiglia D,Cestelli A,Di Liegro C,Bonfanti L,Di Liegro I

更新日期：1992-06-01 00:00:00

abstract：:Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and cha...

journal_title：Cellular and molecular neurobiology

authors： Kolko M,Christoffersen NR,Varoqui H,Bazan NG

更新日期：2005-11-01 00:00:00

abstract：:(1) A Little information exists on the distribution of Slit-Robo-GTPase activating proteins (srGAPs), particularly about their intracellular locations, which may provide further clues to their functions. The purpose of this study is to elucidate the expression patterns of the three srGAPs in wild-type rat brains at ad...

journal_title：Cellular and molecular neurobiology

authors： Yao Q,Jin WL,Wang Y,Ju G

更新日期：2008-02-01 00:00:00

abstract：:The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesi...

journal_title：Cellular and molecular neurobiology

authors： Nampoothiri SS,Rajanikant GK

更新日期：2019-03-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)), a major reactive oxygen species produced during oxidative stress, has been implicated in the pathophysiology of various neurodegenerative conditions. Cyperus rotundus is a traditional medicinal herb that has recently found applications in food and confectionary industries. In the current ...

journal_title：Cellular and molecular neurobiology

authors： Kumar KH,Khanum F

更新日期：2013-01-01 00:00:00

abstract：:1. Antidepressants have been used clinically for many years; however, the neurochemical mechanism for their therapeutic effect has not been clarified yet. Recent reports indicate that chronic antidepressant treatment directly affects the postsynaptic membrane to increase the coupling between the stimulatory GTP-bindin...

journal_title：Cellular and molecular neurobiology

authors： Kamada H,Saito T,Hatta S,Toki S,Ozawa H,Watanabe M,Takahata N

更新日期：1999-02-01 00:00:00

abstract：:1. The central nervous systems (CNS) of males and females differ in the control mechanisms for the release of gonadotropins from the anterior pituitary gland as well as the capacity to display sex specific behaviors. 2. In guinea pigs and monkeys, these differences are organized through the actions of prenatal androge...

journal_title：Cellular and molecular neurobiology

authors： Resko JA,Roselli CE

更新日期：1997-12-01 00:00:00

abstract：:1. Neurotrophins and serotonin have both been implicated in the pathophysiology of depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor. 3. Transgenic mice overe...

journal_title：Cellular and molecular neurobiology

authors： Koponen E,Rantamäki T,Voikar V,Saarelainen T,MacDonald E,Castrén E

更新日期：2005-09-01 00:00:00

abstract：:microRNAs (miRNAs) comprise a class of ~18-25 nucleotide (nt) single-stranded non-coding RNAs (sncRNAs) that are the smallest known carriers of gene-encoded, post-transcriptional regulatory information in both plants and animals. There are many fundamental similarities between plant and animal miRNAs-the miRNAs of bot...

journal_title：Cellular and molecular neurobiology

authors： Zhao Y,Cong L,Lukiw WJ

更新日期：2018-01-01 00:00:00

abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

journal_title：Cellular and molecular neurobiology

authors： Rutigliano G,Zucchi R

更新日期：2020-03-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:1. Pontogeniculooccipital (PGO) waves are recorded during rapid eye movement (REM) sleep from the pontine reticular formation. 2. PGO wave-like field potentials can also be recorded in many other parts of the brain in addition to the pontine reticular formation, but their distribution is different in different species...

journal_title：Cellular and molecular neurobiology

authors： Datta S

更新日期：1997-06-01 00:00:00

abstract：:Contextual fear conditioning is a paradigm for investigating cellular mechanisms involved in hippocampus-dependent memory. Earlier, we showed that standardised extract of Bacopa monniera (CDRI-08) improves hippocampus-dependent learning in postnatal rats by elevating the level of serotonin (5-hydroxytryptamine, 5-HT),...

journal_title：Cellular and molecular neurobiology

authors： Preethi J,Singh HK,Venkataraman JS,Rajan KE

更新日期：2014-05-01 00:00:00

abstract：:Ischemic preconditioning (IPC) represents an important adaptation of CNS to sub-lethal ischemia, which results in increased tolerance of CNS to the lethal ischemia. Ischemia-induced mitochondrial apoptosis is considered to be an important event leading to neuronal cell death after cerebral blood flow arrest. In presen...

journal_title：Cellular and molecular neurobiology

authors： Racay P,Chomova M,Tatarkova Z,Kaplan P,Hatok J,Dobrota D

更新日期：2009-09-01 00:00:00

abstract：:Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatment. To investigate the mRNA expression of neurotrophin...

journal_title：Cellular and molecular neurobiology

authors： Dmitrieva VG,Povarova OV,Skvortsova VI,Limborska SA,Myasoedov NF,Dergunova LV

更新日期：2010-01-01 00:00:00

abstract：:To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

journal_title：Cellular and molecular neurobiology

authors： Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

更新日期：2020-10-01 00:00:00

abstract：:The role of NO in epileptogenesis has been studied in different experimental models, and the reported results have been highly contradictory. The current study aimed to determine the role of NO in mechanisms of D: ,L: -homocysteine-thiolactone (H) induced seizures by testing the action of L: -arginine (NO precursor) a...

journal_title：Cellular and molecular neurobiology

authors： Hrncić D,Rasić-Marković A,Krstić D,Macut D,Djuric D,Stanojlović O

更新日期：2010-03-01 00:00:00

abstract：:The transforming growth factor betas (TGFbetas) are context-dependent regulators of neurons in vitro, but their physiological functions in the brain are unclear. Haploinsufficiency of either Tgfbeta1 or Tgfbeta2 leads to age-related deterioration of neurons, but the development of the brain is normal in the full absen...

journal_title：Cellular and molecular neurobiology

authors： Asano Y,Koishi K,Frugier T,McLennan IS

更新日期：2009-07-01 00:00:00

abstract：:1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity. 2....

journal_title：Cellular and molecular neurobiology

authors： Guevara BH,Cespedes GC,Cubeddu LX

更新日期：2002-12-01 00:00:00

abstract：:Normokalemic periodic paralysis (normoPP) is a type of skeletal muscle function disorder which is characterized by paralysis attack with concomitant normal serum potassium level. We previously reported that R675Q mutation of human skeletal muscle voltage-gated sodium channel α subunit (SCN4A) may be the novel mutation...

journal_title：Cellular and molecular neurobiology

authors： Wu L,Zhang B,Kang Y,Wu W

更新日期：2014-07-01 00:00:00

abstract：:Endothelins have been implicated in the regulation of cell proliferation, differentiation, and apoptosis, but the mechanisms of these complex events are not yet fully understood. Although the nuclear factor-kappaB (NF-kappaB) was shown to play a prominent role in the above processes, its participation in endothelin re...

journal_title：Cellular and molecular neurobiology

authors： Mangelus M,Galron R,Naor Z,Sokolovsky M

更新日期：2001-12-01 00:00:00

abstract：:The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immedia...

journal_title：Cellular and molecular neurobiology

authors： Myers B,McKlveen JM,Herman JP

更新日期：2012-02-01 00:00:00

abstract：:The effects of the divalent cations Ca and Mg on the properties of ACh-activated channels at the frog neuromuscular junction were studied using a two-microelectrode voltage clamp. The divalent cation concentration was varied from 2 to 40 mM in solutions containing 50% normal Na. The reversal potential was determined b...

journal_title：Cellular and molecular neurobiology

authors： Lewis CA

更新日期：1984-09-01 00:00:00