Abstract：
:1. Neurotrophins and serotonin have both been implicated in the pathophysiology of depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor. 3. Transgenic mice overexpressing the full-length trkB receptor (TrkB.TK+) and showing increased trkB activity in brain, and their wild type (WT) littermates, were injected with the antidepressant fluoxetine or saline, and analyzed behaviorally in the forced swimming test paradigm and biochemically for the concentrations of brain monoamines and their metabolites. 4. The TrkB.TK+ mice displayed increased latency to immobility in the forced swim test, suggesting resistance to behavioral despair. 5. Fluoxetine increased the latency to immobility in wild-type mice to a similar level as seen in the trkB.TK+ mice after saline treatment, but had no further behavioral effect in the swimming behavior of the trkB.TK+ mice. 6. Only minor differences in the levels of brain monoamines and their metabolites were observed between the transgenic and wild-type mice. 7. These data, together with other recent observations, suggest that trkB activation may play a critical role in the behavioral responses to antidepressant drugs in mice.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Koponen E,Rantamäki T,Voikar V,Saarelainen T,MacDonald E,Castrén Edoi
10.1007/s10571-005-8468-zsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
973-80issue
6eissn
0272-4340issn
1573-6830journal_volume
25pub_type
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
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pub_type： 已发布勘误
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journal_title：Cellular and molecular neurobiology
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更新日期：1996-12-01 00:00:00
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9408-0
更新日期：2009-12-01 00:00:00
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journal_title：Cellular and molecular neurobiology
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00711562
更新日期：1993-12-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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