Expression and subcellular location of alpha-synuclein during mouse-embryonic development.

abstract：:The present study was undertaken to evaluate whether estrogen deprivation might lead to mitochondrial alteration of hippocampal neurons of ovariectomized (OVX) rats, and to evaluate the protective effect of estrogen and phytoestrogen on the mitochondrial alteration. First, OVX rats were used to mimic the pathologic ch...

journal_title：Cellular and molecular neurobiology

authors： Xu XW,Shi C,He ZQ,Ma CM,Chen WH,Shen YP,Guo Q,Shen CJ,Xu J

更新日期：2008-09-01 00:00:00

abstract：:An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent pas...

journal_title：Cellular and molecular neurobiology

authors： Tiwari RK,Singh S,Gupta CL,Bajpai P

更新日期：2020-07-20 00:00:00

abstract：:While light is the basic element for inducing vision and modulating circadian rhythms, excessive light has been reported to have a negative effect on the survival of various types of retinal cells. Among them photoreceptors and retinal pigment epithelial (RPE) cells degeneration after light exposure is widely observed...

journal_title：Cellular and molecular neurobiology

authors： Zhao Y,Shen Y

更新日期：2020-11-01 00:00:00

abstract：:Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer's disease (AD). Autophagy plays an important role in generatio...

journal_title：Cellular and molecular neurobiology

authors： Li Q,Liu Y,Sun M

更新日期：2017-04-01 00:00:00

abstract：:1. Five drugs with the predominant pharmacologic effect of inhibiting the neuronal reuptake of serotonin are available worldwide for clinical use. This class of psychoactive drugs, known as selective serotonin reuptake inhibitors (SSRIs), is comprised of fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram....

journal_title：Cellular and molecular neurobiology

authors： DeVane CL

更新日期：1999-08-01 00:00:00

abstract：:Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population responds to specific stimuli or insult. These characteristics led to their extensive application in the study of molecular interactions and represent a valuable to...

journal_title：Cellular and molecular neurobiology

authors： Roque C,Baltazar G

更新日期：2017-11-01 00:00:00

abstract：:Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction...

journal_title：Cellular and molecular neurobiology

authors： Shtark MB,Gainutdinov KL,Khichenko VI,Starostina MV

更新日期：1981-09-01 00:00:00

abstract：:Our previous study showed that RalA-binding protein 1 (RLIP76) is overexpressed in gliomas and is associated with higher tumour grade and decreased patient survival. Furthermore, RLIP76 downregulation increases chemosensitivity of glioma cells to temozolomide by inducing apoptosis. However, other mechanisms underlying...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Cai Z,Liang Q,Wang Q,Lu Y,Hu L,Hu G

更新日期：2017-04-01 00:00:00

abstract：:1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

journal_title：Cellular and molecular neurobiology

authors： Schorderet M,Nowak JZ

更新日期：1990-09-01 00:00:00

abstract：:1. The expression of monocyte chemoattractant protein-1 (MCP-1) was examined in stroke-prone spontaneously hypertensive rats with transient global ischemia in order to study the involvement of the infiltration of blood monocytes in the mechanism of ischemia-related neuronal death. 2. The brains of the animals with occ...

journal_title：Cellular and molecular neurobiology

authors： Sakurai-Yamashita Y,Shigematsu K,Yamashita K,Niwa M

更新日期：2006-07-01 00:00:00

abstract：:Normokalemic periodic paralysis (normoPP) is a type of skeletal muscle function disorder which is characterized by paralysis attack with concomitant normal serum potassium level. We previously reported that R675Q mutation of human skeletal muscle voltage-gated sodium channel α subunit (SCN4A) may be the novel mutation...

journal_title：Cellular and molecular neurobiology

authors： Wu L,Zhang B,Kang Y,Wu W

更新日期：2014-07-01 00:00:00

abstract：:1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was ...

journal_title：Cellular and molecular neurobiology

authors： Chepkova AN,Sergeeva OA,Haas HL

更新日期：2005-06-01 00:00:00

abstract：:We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion m...

journal_title：Cellular and molecular neurobiology

authors： He W,Chen W,Zhou Y,Tian Y,Liao F

更新日期：2013-07-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) ind...

journal_title：Cellular and molecular neurobiology

authors： Park KC,Shimizu K,Hayakawa T

更新日期：1998-10-01 00:00:00

abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

journal_title：Cellular and molecular neurobiology

authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

更新日期：1998-08-01 00:00:00

abstract：:1. Neural angiotensinergic circuitry located in the lamina terminalis has been proposed to be involved in blood pressure regulation and fluid homeostasis. 2. ANG II binding sites have been described to be localized throughout the lamina terminalis including the subfornical organ (SFO), the median preoptic nucleus (MnP...

journal_title：Cellular and molecular neurobiology

authors： Guilhaume SS,Corrêa FM

更新日期：2001-02-01 00:00:00

abstract：:1. We have used horseradish peroxidase-conjugated protein A- and 125I-protein A to develop immunohistochemical and radioimmunohistochemical methods for the localization of antigens in brain and other tissues of the rat. 2. We visualized methionine-enkephalin fibers in the rat brain by incubating tissue sections with a...

journal_title：Cellular and molecular neurobiology

authors： Correa FM,Guilhaume SS,Saavedra JM

更新日期：1988-03-01 00:00:00

abstract：:In this study, we investigated the actions of high homocysteine (Hcy) levels (100 and 500 microM) on the cytoskeleton of C6 glioma cells. Results showed that the predominant cytoskeletal response was massive formation of actin-containing filopodia at the cell surface that could be related with Cdc42 activation and inc...

journal_title：Cellular and molecular neurobiology

authors： Loureiro SO,Heimfarth L,Lacerda BA,Vidal LF,Soska A,dos Santos NG,de Souza Wyse AT,Pessoa-Pureur R

更新日期：2010-05-01 00:00:00

abstract：:1. We investigated the association of c-Jun with apoptosis within retinal tissue. Explants of the retina of neonatal rats were subject to a variety of procedures that cause apoptosis of specific classes of retinal cells at distinct stages of differentiation. The expression of c-Jun was detected by Western Blot, and im...

journal_title：Cellular and molecular neurobiology

authors： Chiarini LB,de Freitas FG,Leal-Ferreira ML,Tolkovsky A,Linden R

更新日期：2002-12-01 00:00:00

abstract：:Working memory (WM) is a highly heritable cognitive trait that is involved in many higher-level cognitive functions. In the past few years, much evidence has indicated that the reduction of dopamine activity in human brain can impair the WM system of the neuropsychiatric disorders. In this study, we hypothesized that ...

journal_title：Cellular and molecular neurobiology

authors： Gong P,Zhang H,Chi W,Ge W,Zhang K,Zheng A,Gao X,Zhang F

更新日期：2012-08-01 00:00:00

abstract：:Tau truncation is widely detected in Alzheimer's disease brain. Caspases activation is suggested to play a significant role in tau truncation at Aspartate 421 (D421) according to their ability to cleave recombinant tau in vitro. Ample evidence has shown that caspase-6 is involved in cognitive impairment and expressed ...

journal_title：Cellular and molecular neurobiology

authors： Zhao H,Zhao W,Lok K,Wang Z,Yin M

更新日期：2014-04-01 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1), a member of the matrix metalloproteinases family, plays an integral role in extracellular matrix degradation and has been reportedly involved in the regulation of the brain or spinal cord traumatic neurovascular remodeling. Although the critical involvement of MMP-1 in the metastasi...

journal_title：Cellular and molecular neurobiology

authors： Zhou Y,Cui Z,Xia X,Liu C,Zhu X,Cao J,Wu Y,Zhou L,Ben Z,Song Y,Zhang H,Zhang D

更新日期：2014-11-01 00:00:00

abstract：:ERK pathway plays a critical role in the cellular adaptive responses to environmental changes. Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect. In this study, we investigated the effects of morphine-ind...

journal_title：Cellular and molecular neurobiology

authors： Haghparast A,Fatahi Z,Alamdary SZ,Reisi Z,Khodagholi F

更新日期：2014-03-01 00:00:00

abstract：:Anxiety-related disorders are complex illnesses that underlying molecular mechanisms need to be understood. Mitochondria stand as an important link between energy metabolism, oxidative stress, and anxiety. The nuclear factor, erythroid-derived 2,-like 1(Nrf1) is a member of the cap "n" collar subfamily of basic region...

journal_title：Cellular and molecular neurobiology

authors： Khalifeh S,Oryan S,Khodagholi F,Digaleh H,Shaerzadeh F,Maghsoudi N,Zarrindast MR

更新日期：2016-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

journal_title：Cellular and molecular neurobiology

authors： Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

更新日期：2017-04-01 00:00:00

abstract：:Although Butylphthalide (BP) has protective effects that reduce ischemia-induced brain damage and neuronal cell death, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of BP against isch...

journal_title：Cellular and molecular neurobiology

authors： Wen XR,Tang M,Qi DS,Huang XJ,Liu HZ,Zhang F,Wu J,Wang YW,Zhang XB,Guo JQ,Wang SL,Liu Y,Wang YL,Song YJ

更新日期：2016-10-01 00:00:00

abstract：:Compound 511 (511) is specially developed for opioid addiction treatment based on the Ancient Chinese drug rehabilitation literature, and its composition has profound effects in the treatment of drug addiction in various clinical trials and animal experiments. The effect of 511 on the rewarding properties of morphine ...

journal_title：Cellular and molecular neurobiology

authors： Zhang H,Wang Q,Sun Q,Qin F,Nie D,Li Q,Gu Y,Jiang Y,Lu S,Lu Z

更新日期：2020-04-22 00:00:00

abstract：:We have screened new drugs with a view to developing effective drugs against glutamate-induced excitotoxicity. In the present work, we show effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against glutamate-induced excitotoxicity in primary rat glial cultures. Pretreatment of glial cells...

journal_title：Cellular and molecular neurobiology

authors： Kim EA,Hahn HG,Kim KS,Kim TU,Choi SY,Cho SW

更新日期：2010-07-01 00:00:00

abstract：:1. We measured changes in resting membrane potential (Em) and Na-K pump activity, assayed by ouabain-sensitive 86Rb uptake, in response to carbamylcholine (CCh) and its continued presence in single rat skeletal myotubes in culture. 2. CCh caused immediate depolarization from control Em (-80 to -85 mV) to near 0 follow...

journal_title：Cellular and molecular neurobiology

authors： Brodie C,Sampson SR

更新日期：1988-12-01 00:00:00