Light-Induced Retinal Ganglion Cell Damage and the Relevant Mechanisms.

Abstract:

:While light is the basic element for inducing vision and modulating circadian rhythms, excessive light has been reported to have a negative effect on the survival of various types of retinal cells. Among them photoreceptors and retinal pigment epithelial (RPE) cells degeneration after light exposure is widely observed, but light-induced retinal ganglion cell (RGC) damage achieves relatively little attention. The purpose of this article is to summarize the experimental evidence for the possible negative effects of excessive light on RGCs. By searching the database, twenty-six related articles have been included. Taken together, excessive light may insult RGCs through the three main ways: (i) directly action on RGC mitochondria, as well as DNA, resulting in an upregulation of reactive oxygen species (ROS) and subsequently caspase-dependent or -independent cell death; (ii) mediation in gliotransmitters or relevant receptors of retinal glial cells; and (iii) a secondary event to photoreceptors and RPE cells degeneration and subsequent retinal remodeling. So RGCs can certainly be injured by excessive light, especially when they are already energetically compromised in some diseases. And more attentions should be paid to this topic to take timely measures to protect these frail RGCs from being damaged by excessive light.

journal_name

Cell Mol Neurobiol

authors

Zhao Y,Shen Y

doi

10.1007/s10571-020-00819-0

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1243-1252

issue

8

eissn

0272-4340

issn

1573-6830

pii

10.1007/s10571-020-00819-0

journal_volume

40

pub_type

杂志文章,评审
  • Correction to: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1.

    abstract::The original version of this article unfortunately contained a typo in co-author name. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 已发布勘误

    doi:10.1007/s10571-020-00990-4

    authors: Narayan A,Hunkele A,Xu J,Bassoni DL,Pasternak GW,Pan YX

    更新日期:2020-10-31 00:00:00

  • MicroRNA-107 inhibits U87 glioma stem cells growth and invasion.

    abstract::Glioma stem cells (GSCs) are thought to be critical for resistance to radiotherapy and chemotherapy and for tumor recurrence after surgery in glioma patients. Identification of new therapeutic strategies that can target GSCs may thus be critical for improving patient survival. MicroRNAs (miRNAs) are small non-coding R...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-9927-6

    authors: Chen L,Chen XR,Chen FF,Liu Y,Li P,Zhang R,Yan K,Yi YJ,Xu ZM,Jiang XD

    更新日期:2013-07-01 00:00:00

  • Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: histochemical evidence.

    abstract::1. The effect of transient forebrain ischemia on endothelin-1 (ET-1) and endothelin-3 (ET-3) production in the hippocampus of stroke-prone spontaneously hypertensive rats (SHRSPs) was investigated using immunohistochemical techniques. 2. In SHRSPs subjected to 10-min bilateral carotid occlusion, neuronal degeneration ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00712986

    authors: Yamashita K,Kataoka Y,Niwa M,Shigematsu K,Himeno A,Koizumi S,Taniyama K

    更新日期:1993-02-01 00:00:00

  • Effect of acute administration of 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on oxidative stress in cerebral cortex, hippocampus, and cerebellum of rats.

    abstract::Organotellurium compounds have been synthesized since 1840, but pharmacological and toxicological studies about them are still incipient. Therefore, the objective of this study was to verify the effect of acute administration of the organochalcogen 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on some parameters of o...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9547-3

    authors: Funchal C,Carvalho CA,Gemelli T,Centeno AS,Guerra RB,Salvador M,Dani C,Coitinho A,Gomez R

    更新日期:2010-10-01 00:00:00

  • Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.

    abstract::1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/b:cemn.0000005321.11544.cc

    authors: Chiu R,Rey O,Zheng JQ,Twiss JL,Song J,Pang S,Yokoyama KK

    更新日期:2003-12-01 00:00:00

  • Signals involved in targeting membrane proteins to synaptic vesicles.

    abstract::1. Synaptic vesicles (SVs) mediate fast regulated secretion of classical neurotransmitters. In order to perform their task SVs rely on a restrict set of membrane proteins. The mechanisms responsible for targeting these proteins to the SV membrane are still poorly understood. 2. Likewise, little is known about the intr...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1021884319363

    authors: Prado VF,Prado MA

    更新日期:2002-12-01 00:00:00

  • Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin.

    abstract::1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1019865822069

    authors: Vega-Hernández A,Felix R

    更新日期:2002-04-01 00:00:00

  • A topography and ultrastructural characterization of in vivo 5,7-dihydroxytryptamine-labeled serotonin-containing neurons in the central nervous system of Aplysia californica.

    abstract::1. Several weeks after administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia, a dark pigmentation appears in serotonin-containing neurons, and this pigmentation allows visual identification of serotonergic neurons but does not appear to alter their physiology. 2. We have determined the distribution of labeled...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00734932

    authors: Hernádi L,Rózsa KS,Jahan-Parwar B,Carpenter DO

    更新日期:1992-08-01 00:00:00

  • Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte.

    abstract::Acute encephalopathy is a generic term for acute brain dysfunction occurring after infection. Acute encephalopathy induced by influenza virus results in high mortality, and most cases of influenza-associated encephalopathy (IAE) result in brain edema. Administration of diclofenac sodium (DCF), a non-steroidal anti-inf...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-9905-z

    authors: Asai H,Kakita H,Aoyama M,Nagaya Y,Saitoh S,Asai K

    更新日期:2013-04-01 00:00:00

  • Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.

    abstract::Endothelins have been implicated in the regulation of cell proliferation, differentiation, and apoptosis, but the mechanisms of these complex events are not yet fully understood. Although the nuclear factor-kappaB (NF-kappaB) was shown to play a prominent role in the above processes, its participation in endothelin re...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1015195803445

    authors: Mangelus M,Galron R,Naor Z,Sokolovsky M

    更新日期:2001-12-01 00:00:00

  • Correction to: Pigment Epithelium-Derived Factor Improves Paracellular Blood-Brain Barrier Integrity in the Normal and Ischemic Mouse Brain.

    abstract::The original version of the article unfortunately contained an error in the unit of the protein concentrations under 'Stereotactic Intraparenchymal Injections' subsection in 'Methods' section. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10571-020-00872-9

    authors: Riabinska A,Zille M,Terzi MY,Cordell R,Nieminen-Kelhä M,Klohs J,Piña AL

    更新日期:2020-07-01 00:00:00

  • Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity.

    abstract::1. Studies conducted on the rat arcuate nucleus, an area involved in the development and control of LH and FSH secretion, have shown the existence of hormonally regulated developmental sex differences in synaptic patterns and estrogen-induced synaptic plasticity during adult life. Several questions raised by these fin...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02088177

    authors: Naftolin F,Leranth C,Horvath TL,Garcia-Segura LM

    更新日期:1996-04-01 00:00:00

  • Altered expression of the prion gene in rat astrocyte and neuron cultures treated with prion peptide 106-126.

    abstract::Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-005-8357-5

    authors: Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

    更新日期:2005-12-01 00:00:00

  • Social Behaviour and Epigenetic Status in Adolescent and Adult Rats: The Contribution of Early-Life Stressful Social Experience.

    abstract::Early-life experiences have been linked to individual's epigenetic status and social behaviour. Therefore, the present study aims to test whether the presence of mother suppress the early-life stressful social experience (SSE)-induced effect on social behaviour of adolescent and adult rats, and associated epigenetic c...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-019-00655-x

    authors: Karen C,Rajan KE

    更新日期:2019-04-01 00:00:00

  • Extracellular Matrix Glycoprotein-Derived Synthetic Peptides Differentially Modulate Glioma and Sarcoma Cell Migration.

    abstract::Glycoproteins of the extracellular matrix (ECM) regulate proliferation, migration, and differentiation in numerous cell lineages. ECM functions are initiated by small peptide sequences embedded in large constituents that are recognized by specific cellular receptors. In this study, we have investigated the biological ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-015-0170-1

    authors: Brösicke N,Sallouh M,Prior LM,Job A,Weberskirch R,Faissner A

    更新日期:2015-07-01 00:00:00

  • Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush.

    abstract::As a novel cell cycle inhibitor, PHB2 controls the G1/S transition in cycling cells in a complex manner. Its aberrant expression is closely related to cell carcinogenesis. While its expression and role in peripheral nervous system lesion and repair were still unknown. Here, we performed an acute sciatic nerve crush (S...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-9935-6

    authors: Long L,Huang Y,Wu H,Luan W,Zhang Q,Wen H,Ding T,Wang Y

    更新日期:2013-07-01 00:00:00

  • Aquaporin-mediated fluid regulation in the inner ear.

    abstract::1. The sensory functions of the inner ear (hearing and balance) critically depend on the precise regulation of two fluid compartments of highly desparate ion composition, i.e., the endolymph and the perilymph. 2. The parameters volume, ion composition, and pH need to be held at homeostasis irrespective of the hydratio...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1023636620721

    authors: Beitz E,Zenner HP,Schultz JE

    更新日期:2003-06-01 00:00:00

  • pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.

    abstract::Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0359-y

    authors: Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

    更新日期:2017-03-01 00:00:00

  • Fos protein expression in sacral spinal cord in relation to early phase of cauda equina syndrome in dogs.

    abstract::1. The aim of the present study is to map the incipient phase of Fos expression in the sacral spinal cord neuronal pools of multiple cauda equina constrictions canine model. 2. Fos-positive neurons were found bilaterally in the lateral portion of superficial dorsal horn layers (Laminae I-III) and along the lateral edg...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1012610407025

    authors: Orendácová J,Marsala M,Cízková D,Kafka J,Raceková E,Sulla I,Vanický I,Marsala J

    更新日期:2001-08-01 00:00:00

  • Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation.

    abstract::Smoking is a risk factor for dementia. Cognitive function can be partially restored after quitting smoking, but still lower than never smoked group. The underlying mechanisms still remain unclear. The effects of smoking cessation combined with cerebral chronic hypoperfusion (CCH) on cognitive function have never been ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-020-00992-2

    authors: Meng N,Dong Y,Huo T,Song M,Jiang X,Xiao Y,Lv P

    更新日期:2020-11-06 00:00:00

  • Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells.

    abstract::Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-019-00668-6

    authors: Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

    更新日期:2019-07-01 00:00:00

  • Influence of age on stress responses to metabolic cage housing in rats.

    abstract::1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field te...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1006984402291

    authors: Gil MC,Aguirre JA,Lemoine AP,Segura ET,Barontini M,Armando I

    更新日期:1999-10-01 00:00:00

  • S100, a brain-specific protein: localization and possible role in the snail nervous system.

    abstract::Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00710684

    authors: Shtark MB,Gainutdinov KL,Khichenko VI,Starostina MV

    更新日期:1981-09-01 00:00:00

  • Discovery of atrial natriuretic factor in the brain: its characterization and cardiovascular implication.

    abstract::1. We have devised a radioimmunoassay for atrial natriueretic factor (ANF). Its application to rat brain extract led to the discovery of ANF in the brain. In addition to the hypothalamus and the pontine medullary region, it was widely distributed. 2. ANF in the brain is stored in a low molecular weight form, in contra...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00711444

    authors: Inagami T,Tanaka I,McKenzie JC,Nakamaru M,Takayanagi R,Imada T,Pochet R,Resibois A,Naruse M,Naruse K

    更新日期:1989-03-01 00:00:00

  • Association of SNAREs and calcium channels with the borders of cytoskeletal cages organizes the secretory machinery in chromaffin cells.

    abstract::In chromaffin cells, SNARE proteins, forming the basic exocytotic machinery are present in membrane clusters of 500-600 nm in diameter. These microdomains containing both SNAP-25 and syntaxin-1 are dynamic and the expression of altered forms of SNAREs modifies not only their motion but also the mobility of the associa...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9565-1

    authors: Torregrosa-Hetland CJ,Villanueva J,López-Font I,Garcia-Martinez V,Gil A,Gonzalez-Vélez V,Segura J,Viniegra S,Gutiérrez LM

    更新日期:2010-11-01 00:00:00

  • Biological mechanisms of physical activity in preventing cognitive decline.

    abstract::In order to guarantee better conditions for competition, the nervous system has developed not only mechanisms controlling muscle effectors, but also retrograde systems that, starting from peripheral structures, may influence brain functions. Under such perspective, physical activity could play an important role in inf...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-009-9488-x

    authors: Lista I,Sorrentino G

    更新日期:2010-05-01 00:00:00

  • The effects of sex hormones, prolactin, and chorionic gonadotropin on pineal electrical activity in guinea pigs.

    abstract::Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00710681

    authors: Semm P,Demaine C,Vollrath L

    更新日期:1981-09-01 00:00:00

  • Insulin-like growth factor-1 prevents dorsal root ganglion neuronal tyrosine kinase receptor expression alterations induced by dideoxycytidine in vitro.

    abstract::Dideoxycytidine (zalcitabine, ddC) produces neurotoxic effects. It is particularly important to understand the toxic effects of ddC on different subpopulations of dorsal root ganglion (DRG) neurons which express distinct tyrosine kinase receptor (Trk) and to find therapeutic factors for prevention and therapy for ddC-...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-0001-1

    authors: Liu H,Lu J,He Y,Yuan B,Li Y,Li X

    更新日期:2014-03-01 00:00:00

  • What can we know from pituitary-adrenal hormones about the nature and consequences of exposure to emotional stressors?

    abstract::Exposure to stress induces profound physiological and behavioral changes in the organisms and some of these changes may be important regarding stress-induced pathologies and animal models of psychiatric diseases. Consequences of stress are dependent on the duration of exposure to stressors (acute, chronic), but also o...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-012-9814-6

    authors: Armario A,Daviu N,Muñoz-Abellán C,Rabasa C,Fuentes S,Belda X,Gagliano H,Nadal R

    更新日期:2012-07-01 00:00:00

  • The use of competitive PCR mimic to evaluate a Limulus lambda phage genomic DNA library.

    abstract::1. A lambda phage genomic DNA library for Limulus (L.) polyphemus brain was constructed using the AGEM-12 vector and the host strain KW251. 2. The primary library contained approximately 1.275 x 10(6) independent clones, increasing upon amplfication to 6.66 x 10(9) pfu/ml in a total volume of 58 ml. 3. A total of 28 c...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1007027232412

    authors: Wang Y,Cao Z,Reid EA,Newkirk RF,Ivy MT,Townsel JG

    更新日期:2000-08-01 00:00:00