Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity.

abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...

journal_title：Cellular and molecular neurobiology

authors： Laitinen JT,Laitinen KS,Kokkola T

更新日期：1995-04-01 00:00:00

abstract：:1. Accumulation of different c-erbA transcripts was studied, during rat brain maturation and in cortical neurons differentiating in a serum-free medium, by quantitative Northern blot hybridization. 2. The alpha and beta forms of c-erbA mRNAs exhibit different patterns of accumulation, with a precocious increase in the...

journal_title：Cellular and molecular neurobiology

authors： Castiglia D,Cestelli A,Di Liegro C,Bonfanti L,Di Liegro I

更新日期：1992-06-01 00:00:00

abstract：:1. Effects of 5-hydroxytryptamine (5-HT) on neuronal nicotinic acetylcholine (ACh) receptor channels were investigated by expressing cloned channel subunits in Xenopus oocytes. 2. When channels were expressed with a combination of alpha 3 and beta 4 subunits, 5-HT (10 to 300 microM) reversibly inhibited an inward curr...

journal_title：Cellular and molecular neurobiology

authors： Nakazawa K,Akiyama T,Inoue K

更新日期：1995-08-01 00:00:00

abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

journal_title：Cellular and molecular neurobiology

authors： Takadera T,Ohyashiki T

更新日期：2007-09-01 00:00:00

abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

journal_title：Cellular and molecular neurobiology

authors： Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

更新日期：2015-11-01 00:00:00

abstract：:Our previous study showed that RalA-binding protein 1 (RLIP76) is overexpressed in gliomas and is associated with higher tumour grade and decreased patient survival. Furthermore, RLIP76 downregulation increases chemosensitivity of glioma cells to temozolomide by inducing apoptosis. However, other mechanisms underlying...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Cai Z,Liang Q,Wang Q,Lu Y,Hu L,Hu G

更新日期：2017-04-01 00:00:00

abstract：:We have previously demonstrated that alpha2-adrenoceptors regulate hypothalamic magnocellular oxytocinergic (OXY) neurons in Sprague Dawley rats. Here we investigated whether activation/inhibition of alpha2-adrenoceptors may similarly trigger/downregulate the activity of OXY neurons in control Long Evans (+/+) and per...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2009-09-01 00:00:00

abstract：:Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

journal_title：Cellular and molecular neurobiology

authors： Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

更新日期：2019-07-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant r...

journal_title：Cellular and molecular neurobiology

authors： Chen C,Hu Y,Dong XZ,Zhou XJ,Mu LH,Liu P

更新日期：2018-07-01 00:00:00

abstract：:1. Several intrinsically disordered proteins (IDPs) play principal role in the neurodegenerative processes of various types. Among them, alpha-synuclein is involved in Parkinson's disease, prion protein in transmissible spongiform encephalopathies, and tau protein in Alzheimer's disease (AD) and related tauopathies. N...

journal_title：Cellular and molecular neurobiology

authors： Skrabana R,Sevcik J,Novak M

更新日期：2006-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a devastating motoneuron disorder for which no effective treatment exists. There is some evidence for neuroprotective effects of valproic acid (VPA). The beneficial effects, however, are limited due to the adverse effects of VPA. To overcome this problem, a number of VPA derivates with...

journal_title：Cellular and molecular neurobiology

authors： Ragancokova D,Song Y,Nau H,Dengler R,Krampfl K,Petri S

更新日期：2010-08-01 00:00:00

abstract：:Both sex and steroid hormones are important to consider in human ischemic stroke and its experimental models. Stroke initiates a cascade of changes that lead to neural cell death, but also activates endogenous protective processes that counter the deleterious consequences of ischemia. Steroids may be part of these cer...

journal_title：Cellular and molecular neurobiology

authors： Guennoun R,Zhu X,Fréchou M,Gaignard P,Slama A,Liere P,Schumacher M

更新日期：2019-05-01 00:00:00

abstract：:The stimulation of peripheral opioid receptors counteracts thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 cells in mice, through the activation of the nitric oxide/cGMP/ATP-sensitive K+-channels (NO/cGMP/K(+) (ATP)) cascade (Menéndez et al. 2007, Neuropharmacology 53:71-80). We aimed to eluc...

journal_title：Cellular and molecular neurobiology

authors： Curto-Reyes V,Juárez L,García-Pérez E,Fresno MF,Hidalgo A,Menéndez L,Baamonde A

更新日期：2008-11-01 00:00:00

abstract：:We previously reported that inhibition of Rho-kinase (ROCK) by hydroxyl fasudil improves cognitive deficit and neuronal damage in rats with chronic cerebral ischemia (Huang et al., Cell Mol Neurobiol 28:757-768, 2008). In this study, fasudil mesylate (FM) was investigated for its neuroprotective potential in rats with...

journal_title：Cellular and molecular neurobiology

authors： Li Q,Huang XJ,He W,Ding J,Jia JT,Fu G,Wang HX,Guo LJ

更新日期：2009-03-01 00:00:00

abstract：:Repeated electrical stimulation results in development of seizures and a permanent increase in seizure susceptibility (kindling). The permanence of kindling suggests that chronic changes in gene expression are involved. Kindling at different sites produces specific effects on interictal behaviors such as spatial cogni...

journal_title：Cellular and molecular neurobiology

authors： Corcoran ME,Kroes RA,Burgdorf JS,Moskal JR

更新日期：2011-08-01 00:00:00

abstract：:The anorexigenic molecule nesfatin-1 has recently been taken as a potential mood regulator, but the potential mechanisms remain unknown. Results of our previous study have demonstrated that nesfatin-1 could induce anxiety- and depression-like behaviors in rats, accompanied by the hyperactivity of the hypothalamic-pitu...

journal_title：Cellular and molecular neurobiology

authors： Chen Z,Xu YY,Ge JF,Chen FH

更新日期：2018-04-01 00:00:00

abstract：:1. Transient forebrain ischemia in adult rats, induced by 10 min of bilateral carotid occlusion and an arterial hypotension of 40 mmHg, caused substantial damage not only to CA-1 neurons in hippocampus but also to epithelial cells in lateral ventricle choroid plexus. 2. When transient forebrain ischemia was followed b...

journal_title：Cellular and molecular neurobiology

authors： Johanson CE,Palm DE,Primiano MJ,McMillan PN,Chan P,Knuckey NW,Stopa EG

更新日期：2000-04-01 00:00:00

abstract：:The Pax5, a B-cell-Specific Activator Protein (BSAP) and redox-sensitive transcription factor, is expressed in the immune-privileged brain, B-lymphocytes, lymph nodes and spleen. PAX5-mediated immune pathway has also been described in the progression of Glioblastoma multiforme. However, the status of Pax5 and its role...

journal_title：Cellular and molecular neurobiology

authors： Maurya SK,Mishra R

更新日期：2018-05-01 00:00:00

abstract：:Glioblastoma is the most malignant primary brain tumor and is very resistant to treatment; hence, it has a poor prognosis. Neurotensin receptor type 1 (NTSR1) plays a key role in cancer malignancy and has potential therapeutic applications. However, the presence and function of neurotensin (NTS) receptors in glioblast...

journal_title：Cellular and molecular neurobiology

authors： Ayala-Sarmiento AE,Martinez-Fong D,Segovia J

更新日期：2015-08-01 00:00:00

abstract：:1. Pontogeniculooccipital (PGO) waves are recorded during rapid eye movement (REM) sleep from the pontine reticular formation. 2. PGO wave-like field potentials can also be recorded in many other parts of the brain in addition to the pontine reticular formation, but their distribution is different in different species...

journal_title：Cellular and molecular neurobiology

authors： Datta S

更新日期：1997-06-01 00:00:00

abstract：:Overexpression of suppressor of cytokine signalling 2 (SOCS2) has been shown to promote hippocampal neurogenesis in vivo and promote neurite outgrowth of neurons in vitro. In the adult mouse brain, SOCS2 is most highly expressed in the hippocampal CA3 region and at lower levels in the dentate gyrus, an expression patt...

journal_title：Cellular and molecular neurobiology

authors： Basrai HS,Turbic A,Christie KJ,Turnley AM

更新日期：2017-07-01 00:00:00

abstract：AIM:A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS:Electron microscop...

journal_title：Cellular and molecular neurobiology

authors： Sombers LA,Maxson MM,Ewing AG

更新日期：2007-08-01 00:00:00

abstract：:Early-life experiences have been linked to individual's epigenetic status and social behaviour. Therefore, the present study aims to test whether the presence of mother suppress the early-life stressful social experience (SSE)-induced effect on social behaviour of adolescent and adult rats, and associated epigenetic c...

journal_title：Cellular and molecular neurobiology

authors： Karen C,Rajan KE

更新日期：2019-04-01 00:00:00

abstract：:Glioblastoma Multiforme (GBM) is an aggressive form of brain Tumor that has few cures. In this study, we analyze the anti-proliferative effects of a new molecule JQ1 against GBMs induced in Wistar Rats. JQ1 is essentially a Myc inhibitor. c-Myc is also known for altering the biochemistry of a tumor cell. Therefore, th...

journal_title：Cellular and molecular neurobiology

authors： Rajagopalan V,Vaidyanathan M,Janardhanam VA,Bradner JE

更新日期：2014-10-01 00:00:00

abstract：:Thyroid hormone (T(3)) plays an essential role in the central nervous system development. Astrocytes mediate many of the T(3) effects in the growth and differentiation of cerebellum. In culture, T(3) induces cerebellar astrocytes to secrete growth factors, mainly FGF(2), and alters the expression and organization of t...

journal_title：Cellular and molecular neurobiology

authors： Mendes-de-Aguiar CB,Costa-Silva B,Alvarez-Silva M,Tasca CI,Trentin AG

更新日期：2008-09-01 00:00:00

abstract：:1. The effects of acetylcholine (ACh) on the soma of cultured ventrocaudal sensory neurons from the pleural ganglia of Aplysia kurodai were characterized. 2. Whole-cell recording was used for current and voltage clamping. ACh and other drugs were microapplied to the membranes of the cultured neurons. 3. Microapplicati...

journal_title：Cellular and molecular neurobiology

authors： Ichinose M,Sawada M,Maeno T,McAdoo DJ

更新日期：1989-06-01 00:00:00

abstract：:1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was ...

journal_title：Cellular and molecular neurobiology

authors： Chepkova AN,Sergeeva OA,Haas HL

更新日期：2005-06-01 00:00:00

abstract：:1. Gonadotropin-releasing hormone (GnRH) was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, during evolution the peptide was subject to gene duplication and structural changes, and multiple m...

journal_title：Cellular and molecular neurobiology

authors： King JA,Millar RP

更新日期：1995-02-01 00:00:00

abstract：:1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

journal_title：Cellular and molecular neurobiology

authors： Platt B,Büsselberg D

更新日期：1994-12-01 00:00:00

abstract：:Oxidative glutamate toxicity plays a vital role in the neurodegeneration diseases, including Alzheimer's diseases (AD). This study set out with the aim to investigate the beneficial effects of fangchinoline (FAN), a natural alkaloid, against glutamate-induced oxidative damage, and to clarify the underlying cellular an...

journal_title：Cellular and molecular neurobiology

authors： Bao F,Tao L,Zhang H

更新日期：2019-11-01 00:00:00