Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles.

abstract：:1. Nitric oxide (NO) is thought to play a neuromodulatory role in the nervous system of vertebrate and invertebrate species. In the hornworm Manduca sexta, NO-mediated signaling has been implicated in behavioral and developmental processes, but its exact function in neurons is unknown. In this study, we identify speci...

journal_title：Cellular and molecular neurobiology

authors： Zayas RM,Trimmer BA

更新日期：2007-03-01 00:00:00

abstract：:We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...

journal_title：Cellular and molecular neurobiology

authors： Osborn O,Sanchez-Alavez M,Brownell SE,Ross B,Klaus J,Dubins J,Beutler B,Conti B,Bartfai T

更新日期：2010-01-01 00:00:00

abstract：:1. It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTM intact for the same task in the same animal. 2. The effect of a lar...

journal_title：Cellular and molecular neurobiology

authors： Izquierdo LA,Barros DM,Vianna MR,Coitinho A,deDavid e Silva T,Choi H,Moletta B,Medina JH,Izquierdo I

更新日期：2002-06-01 00:00:00

abstract：:The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both es...

journal_title：Cellular and molecular neurobiology

authors： Singh S,Thakur MK

更新日期：2011-04-01 00:00:00

abstract：:1. We measured changes in resting membrane potential (Em) and Na-K pump activity, assayed by ouabain-sensitive 86Rb uptake, in response to carbamylcholine (CCh) and its continued presence in single rat skeletal myotubes in culture. 2. CCh caused immediate depolarization from control Em (-80 to -85 mV) to near 0 follow...

journal_title：Cellular and molecular neurobiology

authors： Brodie C,Sampson SR

更新日期：1988-12-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

journal_title：Cellular and molecular neurobiology

authors： Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

更新日期：2017-04-01 00:00:00

abstract：:Spaceflight and simulated microgravity both affect learning and memory, which are mostly controlled by the hippocampus. However, data about molecular alterations in the hippocampus in real or simulated microgravity conditions are limited. Adult Wistar rats were recruited in the experiments. Here we analyzed whether sh...

journal_title：Cellular and molecular neurobiology

authors： Berezovskaya AS,Tyganov SA,Nikolaeva SD,Naumova AA,Merkulyeva NS,Shenkman BS,Glazova MV

更新日期：2020-07-18 00:00:00

abstract：:Ischemic preconditioning (IPC) represents an important adaptation of CNS to sub-lethal ischemia, which results in increased tolerance of CNS to the lethal ischemia. Ischemia-induced mitochondrial apoptosis is considered to be an important event leading to neuronal cell death after cerebral blood flow arrest. In presen...

journal_title：Cellular and molecular neurobiology

authors： Racay P,Chomova M,Tatarkova Z,Kaplan P,Hatok J,Dobrota D

更新日期：2009-09-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

journal_title：Cellular and molecular neurobiology

authors： Schorderet M,Nowak JZ

更新日期：1990-09-01 00:00:00

abstract：:EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease. Howev...

journal_title：Cellular and molecular neurobiology

authors： Ni H,Shen J,Song Y,Cao M,Liu X,Huang J,Zhang W,Xie L,Ning X,Ke K

更新日期：2016-08-01 00:00:00

abstract：:1. Doubly transgenic mice were some differences in the period proceeding of the development of Abeta-42 deposits and behavioral deficits. It was not characterized human mutant PS2 (hPS2) with APPsw in the brains of double transgenic mice. The aim of this study was to examine whether doubly transgenic mice co-expressin...

journal_title：Cellular and molecular neurobiology

authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Song CW,Lee SH,Kim YK

更新日期：2005-08-01 00:00:00

abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...

journal_title：Cellular and molecular neurobiology

authors： Foley TD,Clark AR,Stredny ES,Wierbowski BM

更新日期：2012-03-01 00:00:00

abstract：:Acute encephalopathy is a generic term for acute brain dysfunction occurring after infection. Acute encephalopathy induced by influenza virus results in high mortality, and most cases of influenza-associated encephalopathy (IAE) result in brain edema. Administration of diclofenac sodium (DCF), a non-steroidal anti-inf...

journal_title：Cellular and molecular neurobiology

authors： Asai H,Kakita H,Aoyama M,Nagaya Y,Saitoh S,Asai K

更新日期：2013-04-01 00:00:00

abstract：:In this study, we investigated the actions of high homocysteine (Hcy) levels (100 and 500 microM) on the cytoskeleton of C6 glioma cells. Results showed that the predominant cytoskeletal response was massive formation of actin-containing filopodia at the cell surface that could be related with Cdc42 activation and inc...

journal_title：Cellular and molecular neurobiology

authors： Loureiro SO,Heimfarth L,Lacerda BA,Vidal LF,Soska A,dos Santos NG,de Souza Wyse AT,Pessoa-Pureur R

更新日期：2010-05-01 00:00:00

abstract：:1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...

journal_title：Cellular and molecular neurobiology

authors： Chiu R,Rey O,Zheng JQ,Twiss JL,Song J,Pang S,Yokoyama KK

更新日期：2003-12-01 00:00:00

abstract：:Smoking is a risk factor for dementia. Cognitive function can be partially restored after quitting smoking, but still lower than never smoked group. The underlying mechanisms still remain unclear. The effects of smoking cessation combined with cerebral chronic hypoperfusion (CCH) on cognitive function have never been ...

journal_title：Cellular and molecular neurobiology

authors： Meng N,Dong Y,Huo T,Song M,Jiang X,Xiao Y,Lv P

更新日期：2020-11-06 00:00:00

abstract：:(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for these effects are unknown. (2) The present study analyzed morphological changes in motoneurons distal to the lesion site from rats with or without progesterone t...

journal_title：Cellular and molecular neurobiology

authors： González SL,López-Costa JJ,Labombarda F,González Deniselle MC,Guennoun R,Schumacher M,De Nicola AF

更新日期：2009-02-01 00:00:00

abstract：:The expression of muscarinic acetylcholine binding sites and of cholinesterases was studied in extracts prepared from discrete regions of the human fetal brain, between the gestational ages of 14 and 24 weeks. The specific binding of [3H]N-methyl-4-piperidyl benzilate [( 4H]-4NMPB) to muscarinic binding sites ranged b...

journal_title：Cellular and molecular neurobiology

authors： Egozi Y,Sokolovsky M,Schejter E,Blatt I,Zakut H,Matzkel A,Soreq H

更新日期：1986-03-01 00:00:00

abstract：:Astragalosides (AST) are reported to be neuroprotective in focal cerebral ischemic models in vivo. In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding bac...

journal_title：Cellular and molecular neurobiology

authors： Chiu BY,Chang CP,Lin JW,Yu JS,Liu WP,Hsu YC,Lin MT

更新日期：2014-08-01 00:00:00

abstract：:Neuroinflammation has become an important underlying factor in many cardiovascular disorders, including hypertension. Previously we showed that elevated angiotensin II (Ang II) and angiotensin II type I receptor (AT1R) expression levels can increase neuroinflammation leading to hypertension. We also found that kinin B...

journal_title：Cellular and molecular neurobiology

authors： Parekh RU,Robidoux J,Sriramula S

更新日期：2020-07-01 00:00:00

abstract：:To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

journal_title：Cellular and molecular neurobiology

authors： Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

更新日期：2020-10-01 00:00:00

abstract：:The hypernociceptive role played by the chemokine CCL2, and its main receptor, CCR2, in pathological settings is being increasingly recognized. We aimed to characterize the involvement of spinal CCL2 in the hyperalgesia due to the intratibial inoculation of fibrosarcoma NCTC 2472 cells in mice. The intrathecal (i.t.) ...

journal_title：Cellular and molecular neurobiology

authors： Pevida M,González-Rodríguez S,Lastra A,García-Suárez O,Hidalgo A,Menéndez L,Baamonde A

更新日期：2014-01-01 00:00:00

abstract：:Thyroid hormone (T(3)) plays an essential role in the central nervous system development. Astrocytes mediate many of the T(3) effects in the growth and differentiation of cerebellum. In culture, T(3) induces cerebellar astrocytes to secrete growth factors, mainly FGF(2), and alters the expression and organization of t...

journal_title：Cellular and molecular neurobiology

authors： Mendes-de-Aguiar CB,Costa-Silva B,Alvarez-Silva M,Tasca CI,Trentin AG

更新日期：2008-09-01 00:00:00

abstract：:Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction...

journal_title：Cellular and molecular neurobiology

authors： Shtark MB,Gainutdinov KL,Khichenko VI,Starostina MV

更新日期：1981-09-01 00:00:00

abstract：:Oxidative glutamate toxicity plays a vital role in the neurodegeneration diseases, including Alzheimer's diseases (AD). This study set out with the aim to investigate the beneficial effects of fangchinoline (FAN), a natural alkaloid, against glutamate-induced oxidative damage, and to clarify the underlying cellular an...

journal_title：Cellular and molecular neurobiology

authors： Bao F,Tao L,Zhang H

更新日期：2019-11-01 00:00:00

abstract：:1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTP gamma S, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were st...

journal_title：Cellular and molecular neurobiology

authors： Heemskerk FM,Zorad S,Xu N,Gutkind SJ,Saavedra JM

更新日期：1999-04-01 00:00:00

abstract：:Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms underlying the increased iron are still unknown. Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1)...

journal_title：Cellular and molecular neurobiology

authors： Wang J,Bi M,Xie J

更新日期：2015-07-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00