当前位置： SCI文献检索 > CELLULAR AND MOLECULAR NEUROBIOLOGY期刊下所有文献 > Beneficial effect of astragalosides on stroke condition using PC12 cells under oxygen glucose deprivation and reperfusion.

Beneficial effect of astragalosides on stroke condition using PC12 cells under oxygen glucose deprivation and reperfusion.

Abstract：

:Astragalosides (AST) are reported to be neuroprotective in focal cerebral ischemic models in vivo. In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding back oxygen and glucose (OGD-R)] was used to induce in vitro ischemia reperfusion injury in differentiated rat pheochromocytoma PC12 cells. AST (1, 100, and 200 µg/mL) were added to the culture after 5 h of the OGD ischemic insult and was present during the reoxygenation phases. A key finding was that OGD-R decreased cell viability, increased lactate dehydrogenase, increased reactive oxygen species, apoptosis, autophagy, functional impairment of mitochondria, and endoplasmic reticulum stress in PC12 cells, all of which AST treatment significantly reduced. In addition, AST attenuated OGD-R-induced cell loss through P38 MAPK activation a neuroprotective effect blunted by SB203580, a specific inhibitor of P38 MAPK. Our data suggest that both apoptosis and autophagy are important characteristics of OGD-R-induced PC12 death and that treating PC12 cells with AST blocked OGD-R-induced apoptosis and autophagy by suppressing intracellular oxidative stress, functional impairment of mitochondria, and endoplasmic reticulum stress. Our data provide identification of AST that can concomitantly inhibit multiple cells death pathways following OGD injuries in neural cells.

journal_name

Cell Mol Neurobiol

journal_title

Cellular and molecular neurobiology

authors

Chiu BY,Chang CP,Lin JW,Yu JS,Liu WP,Hsu YC,Lin MT

doi

10.1007/s10571-014-0059-4

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

825-37

issue

6

eissn

0272-4340

issn

1573-6830

journal_volume

34

pub_type

杂志文章

相关文献

CELLULAR AND MOLECULAR NEUROBIOLOGY文献大全
  • Matrix metalloproteinase-1 (MMP-1) expression in rat spinal cord injury model.

    abstract：:Matrix metalloproteinase-1 (MMP-1), a member of the matrix metalloproteinases family, plays an integral role in extracellular matrix degradation and has been reportedly involved in the regulation of the brain or spinal cord traumatic neurovascular remodeling. Although the critical involvement of MMP-1 in the metastasi...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0090-5

    authors： Zhou Y,Cui Z,Xia X,Liu C,Zhu X,Cao J,Wu Y,Zhou L,Ben Z,Song Y,Zhang H,Zhang D

    更新日期：2014-11-01 00:00:00

  • Altering cellular signaling pathways enhance gene silencing activity of shRNA, shRNA.ribozyme, and shRNA.antisense in neuroblastoma cells.

    abstract：:1. RNA interference (RNAi) is a multicomponent machinery that operates in a sequence-specific manner to repress the expression of genes in most eukaryotic cells. 2. Here we wanted to investigate in a murine neuroblastoma cell line (NBP2) (a) if replacement of the loop of the short hairpin RNA (shRNA) with a hammerhead...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-004-6919-6

    authors： Nahreini P,Hanson AJ,Andreatta CP,Koustas WT,Prasad KN

    更新日期：2004-12-01 00:00:00

  • The 21-aminosteroid U-74389F increases the number of glial fibrillary acidic protein-expressing astrocytes in the spinal cord of control and Wobbler mice.

    abstract：:1. Wobbler mice suffer an autosomal recessive mutation producing severe motoneuron degeneration and dense astrogliosis, with increased levels of glial fibrillary acidic protein (GFAP) in the spinal cord and brain stem. They have been considered animal models of amyotrophic lateral sclerosis and infantile spinal muscul...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02578387

    authors： Gonzalez Deniselle MC,Gonzalez SL,Piroli GG,Lima AE,De Nicola AF

    更新日期：1996-02-01 00:00:00

  • Pulsed radiofrequency reduced complete Freund's adjuvant-induced mechanical hyperalgesia via the spinal c-Jun N-terminal kinase pathway.

    abstract：:Pulsed radiofrequency (PRF) treatment involves the pulsed application of a radiofrequency electric field to a nerve. The technology offers pain relief for patients suffering from chronic pain who do not respond well to conventional treatments. We tested whether PRF treatment attenuated complete Freund's adjuvant (CFA)...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-0003-z

    authors： Chen KH,Yang CH,Juang SE,Huang HW,Cheng JK,Sheen-Chen SM,Cheng JT,Lin CR

    更新日期：2014-03-01 00:00:00

  • Proteomic Analysis of the Antidepressant Effects of Shen-Zhi-Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism.

    abstract：:Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant r...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10571-018-0582-9

    authors： Chen C,Hu Y,Dong XZ,Zhou XJ,Mu LH,Liu P

    更新日期：2018-07-01 00:00:00

  • Kinetics of acetylcholine-activated cation channel blockade by the calcium antagonist D-600 in Aplysia neurons.

    abstract：:The effects of the calcium channel blocker D-600 on the cation channels activated by acetylcholine (ACh) was studied in voltage-clamped Aplysia neurons by voltage-jump relaxation analysis. D-600 blocked the steady-state ACh current in a highly voltage-dependent manner, the degree of antagonism increasing with membrane...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00734714

    authors： Slater NT,Haas HL,Carpenter DO

    更新日期：1983-12-01 00:00:00

  • Evidence for site selection during synaptogenesis: the surface distribution of synaptic sites in photoreceptor terminals of the files Musca and Drosophila.

    abstract：:1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02151904

    authors： Meinertzhagen IA,Hu X

    更新日期：1996-12-01 00:00:00

  • Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats.

    abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0209-3

    authors： Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

    更新日期：2015-11-01 00:00:00

  • Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures.

    abstract：:: Oxidative stress has been implicated in a large number of human degenerative diseases, including epilepsy. Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy. Recently, it was demonstrated that the mechanism of LEV differs from that of conventional ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9132-y

    authors： Oliveira AA,Almeida JP,Freitas RM,Nascimento VS,Aguiar LM,Júnior HV,Fonseca FN,Viana GS,Sousa FC,Fonteles MM

    更新日期：2007-05-01 00:00:00

  • Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.

    abstract：:Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced by oxygen and glucose deprivation (OGD) in neonatal rat primary-cultured hip...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-017-0501-5

    authors： Zhao P,Chang RY,Liu N,Wang J,Zhou R,Qi X,Liu Y,Ma L,Niu Y,Sun T,Li YX,He YP,Yu JQ

    更新日期：2018-03-01 00:00:00

  • The use of competitive PCR mimic to evaluate a Limulus lambda phage genomic DNA library.

    abstract：:1. A lambda phage genomic DNA library for Limulus (L.) polyphemus brain was constructed using the AGEM-12 vector and the host strain KW251. 2. The primary library contained approximately 1.275 x 10(6) independent clones, increasing upon amplfication to 6.66 x 10(9) pfu/ml in a total volume of 58 ml. 3. A total of 28 c...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007027232412

    authors： Wang Y,Cao Z,Reid EA,Newkirk RF,Ivy MT,Townsel JG

    更新日期：2000-08-01 00:00:00

  • Morphological characteristics of different types of neurons in the ventrooralis anterior, ventrooralis internus, and ventrooralis posterior nuclei in the human thalamus.

    abstract：:1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00712927

    authors： al-Hussain SM

    更新日期：1992-06-01 00:00:00

  • Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).

    abstract：:Glial cells have various important roles in regulation of brain functions. For such events, extracellular nucleotides/P2 receptors have central roles. Although there have been huge amount of literature about activation of P2 receptors and glial functions, little is known about what happens in glia or the brain if glia...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-012-9869-4

    authors： Kinoshita M,Nasu-Tada K,Fujishita K,Sato K,Koizumi S

    更新日期：2013-01-01 00:00:00

  • Lead as an inductor of some morphological and functional changes in synaptosomes from rat brain.

    abstract：:1. The effect of lead (in vivo) on the uptake of GABA, dopamine, and histidine as a precursor of histamine in synaptosomes obtained from chronically lead-treated rats was studied. 2. Lead decreased the uptake of GABA, increased the uptake of dopamine, and did not change the uptake of histidine. These effects were inde...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02088678

    authors： Jabłońska L,Walski M,Rafałowska U

    更新日期：1994-12-01 00:00:00

  • Persistent calcium inward current in internally perfused snail neuron.

    abstract：:The inactivation process of the calcium current (ICa) was investigated in a molluscan neuron which was perfused intracellularly and voltage-clamped using a suction pipette technique. The decay phase of the ICa contained a very slowly inactivated component (persistent inward current; PIC). The decay time constant of th...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00742977

    authors： Oyama Y,Akaike N,Nishi K

    更新日期：1986-03-01 00:00:00

  • Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex.

    abstract：:The L-type calcium channel blocker nimodipine improves clinical outcome produced by delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While vasoactive mechanisms are strongly implicated in these therapeutic actions of nimodipine, we sought to test whether nimodipine might also regulate ne...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0110-5

    authors： Koskimäki J,Matsui N,Umemori J,Rantamäki T,Castrén E

    更新日期：2015-03-01 00:00:00

  • Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.

    abstract：:Available treatment for Parkinson's disease (PD) is mainly symptomatic instead of halting or reversing degenerative processes affecting the disease. Research on the molecular pathogenesis of PD has suggested reduced trophic support as a possible cause or mediator of neurodegeneration. In animal models of the disease, ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-009-9458-3

    authors： Gyárfás T,Knuuttila J,Lindholm P,Rantamäki T,Castrén E

    更新日期：2010-04-01 00:00:00

  • Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

    abstract：:In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-012-9848-9

    authors： Yan BC,Park JH,Kim SK,Choi JH,Lee CH,Yoo KY,Kwon YG,Kim YM,Kim JD,Won MH

    更新日期：2012-11-01 00:00:00

  • Long-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine.

    abstract：:1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-005-3974-6

    authors： Chepkova AN,Sergeeva OA,Haas HL

    更新日期：2005-06-01 00:00:00

  • Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

    abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-007-9172-y

    authors： Takadera T,Ohyashiki T

    更新日期：2007-09-01 00:00:00

  • Protective effects of Arctium lappa L. roots against hydrogen peroxide-induced cell injury and potential mechanisms in SH-SY5Y cells.

    abstract：:Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots (EAL) on hydrogen peroxide (H2O...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0129-7

    authors： Tian X,Guo LP,Hu XL,Huang J,Fan YH,Ren TS,Zhao QC

    更新日期：2015-04-01 00:00:00

  • Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

    abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-019-00676-6

    authors： Pozdnyakova N,Dudarenko M,Borisova T

    更新日期：2019-07-01 00:00:00

  • Alternative splicing generates diversity of VD1/RPD2 alpha peptides in the central nervous system of Lymnaea stagnalis.

    abstract：:1. Two giant peptidergic neurons, VD1 and RPD2, of the visceral ganglion and right parietal ganglion of Lymnaea stagnalis, respectively, play an important role in the modulation of complex physiological and behavioral adjustments that occur as a result of changes in O2 availability. 2. By cDNA cloning, we have identif...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00735369

    authors： Bogerd J,Van Kesteren RE,Van Heerikhuizen H,Geraerts WP,Veenstra J,Smit AB,Joosse J

    更新日期：1993-04-01 00:00:00

  • Combination of dexamethasone and aminoguanidine reduces secondary damage in compression spinal cord injury.

    abstract：:The study was performed to investigate the effect of combination therapy with aminoguanidine (AG) and dexamethasone (DEX) on the compression spinal cord injury (SCI) in rat. Compared to the control group, the combination therapy group with AG (75 mg/kg) and DEX (0.025 mg/kg) significantly reduced the degree of (1) spi...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-009-9380-8

    authors： Xu WB,Lv G,Wang YF,Lu XH,Huang T,Zhu Y,Jia LS

    更新日期：2009-07-01 00:00:00

  • Radioimmunochemical methods for the quantitative autoradiographic determination of antigens in brain and other tissues.

    abstract：:1. We have used horseradish peroxidase-conjugated protein A- and 125I-protein A to develop immunohistochemical and radioimmunohistochemical methods for the localization of antigens in brain and other tissues of the rat. 2. We visualized methionine-enkephalin fibers in the rat brain by incubating tissue sections with a...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00712912

    authors： Correa FM,Guilhaume SS,Saavedra JM

    更新日期：1988-03-01 00:00:00

  • Autophagy and Alzheimer's Disease.

    abstract：:Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer's disease (AD). Autophagy plays an important role in generatio...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-016-0386-8

    authors： Li Q,Liu Y,Sun M

    更新日期：2017-04-01 00:00:00

  • Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats.

    abstract：:Spaceflight and simulated microgravity both affect learning and memory, which are mostly controlled by the hippocampus. However, data about molecular alterations in the hippocampus in real or simulated microgravity conditions are limited. Adult Wistar rats were recruited in the experiments. Here we analyzed whether sh...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-020-00922-2

    authors： Berezovskaya AS,Tyganov SA,Nikolaeva SD,Naumova AA,Merkulyeva NS,Shenkman BS,Glazova MV

    更新日期：2020-07-18 00:00:00

  • The application of antisense oligonucleotide technology to the brain: some pitfalls.

    abstract：:1. Amphetamine-induced c-fos and egr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological acti...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02088834

    authors： Chiasson BJ,Armstrong JN,Hooper ML,Murphy PR,Robertson HA

    更新日期：1994-10-01 00:00:00

  • Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis.

    abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-009-9439-6

    authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

    更新日期：2010-01-01 00:00:00

  • Shengmai Formula Ameliorates Pathological Characteristics in AD C. elegans.

    abstract：:Shengmai (SM) formula, a classical traditional Chinese medicine formula, is composed of Panax ginseng (Pg), Ophiopogon japonicus (Oj), and Schisandra Chinesis (Sc). SM has been clinically used to treat heart failure and ischemic heart disease. Although SM formula has been reported to be potential for fighting against ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0326-z

    authors： Zhang W,Zhi D,Ren H,Wang D,Wang X,Zhang Z,Fei D,Zhu H,Li H

    更新日期：2016-11-01 00:00:00