当前位置： SCI文献检索 > CELLULAR AND MOLECULAR NEUROBIOLOGY期刊下所有文献 > Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Abstract：

:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is involved in calmodulin inhibitor-induced cell death in PC12 cells. W13, a calmodulin specific inhibitor increased apoptotic cell death with morphological changes characterized by cell shrinkage and nuclear condensation of fragmentation. Glycogen synthase kinase-3 inhibitors prevented calmodulin inhibitor-induced apoptosis. In addition, nerve growth factor and cycloheximide, a protein synthesis inhibitor, completely blocked cell death. Moreover, caspase-3 activation was accompanied by calmodulin inhibitor-induced cell death and inhibited by nerve growth factor. These results suggest that calmodulin inhibitors induce caspase-dependent apoptosis, and the activation of glycogen synthase kinase-3 is involved in the death of PC12 cells.

journal_name

Cell Mol Neurobiol

journal_title

Cellular and molecular neurobiology

authors

Takadera T,Ohyashiki T

doi

10.1007/s10571-007-9172-y

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

783-90

issue

6

eissn

0272-4340

issn

1573-6830

journal_volume

27

pub_type

杂志文章

相关文献

CELLULAR AND MOLECULAR NEUROBIOLOGY文献大全
  • Rab10 Disruption Results in Delayed OPC Maturation.

    abstract：:Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice prov...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-017-0465-5

    authors： Zhang ZH,Zhao WQ,Ma FF,Zhang H,Xu XH

    更新日期：2017-10-01 00:00:00

  • Characterization of NO/cGMP-mediated responses in identified motoneurons.

    abstract：:1. Nitric oxide (NO) is thought to play a neuromodulatory role in the nervous system of vertebrate and invertebrate species. In the hornworm Manduca sexta, NO-mediated signaling has been implicated in behavioral and developmental processes, but its exact function in neurons is unknown. In this study, we identify speci...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9091-3

    authors： Zayas RM,Trimmer BA

    更新日期：2007-03-01 00:00:00

  • Intracellular localization of the HCS2 gene products in identified snail neurons in vivo and in vitro.

    abstract：:1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9025-0

    authors： Ivanova JL,Leonova OG,Popenko VI,Ierusalimsky VN,Korshunova TA,Boguslavsky DV,Malyshev AY,Balaban PM,Belyavsky AV

    更新日期：2006-03-01 00:00:00

  • The striatum and pain modulation.

    abstract：:The aim of this review was to give a general aspect of the sensorial function of the striatum related to pain modulation, which was intensively studied in our laboratory. We analyse the effect of electrical and chemical stimulation of the striatum on the orofacial pain, especially that produced by tooth pulp stimulati...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-011-9737-7

    authors： Barceló AC,Filippini B,Pazo JH

    更新日期：2012-01-01 00:00:00

  • MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.

    abstract：:Bone morphogenic protein (BMP) signaling is crucial for coordinated synaptic growth and plasticity. Here, we show that the nuclear LEM-domain protein MAN1 is a negative regulator of synaptic growth at Drosophila larval and adult neuromuscular junctions (NMJs). Loss of MAN1 is associated with synaptic structural defect...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-016-0442-4

    authors： Laugks U,Hieke M,Wagner N

    更新日期：2017-08-01 00:00:00

  • Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.

    abstract：:Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0323-2

    authors： Wang T,Zhu M,He ZZ

    更新日期：2016-11-01 00:00:00

  • Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.

    abstract：:1. Aminoalkylindoles, typified by WIN 55212-2, bind to G protein-coupled cannabinoid receptors in brain. Although cannabinoids inhibit adenylyl cyclase in NG108-15 neuroblastoma x glioma hybrid cells, cannabinoid receptor binding in these cells has not been described previously. This study compares pharmacological cha...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1026306804802

    authors： Stark S,Pacheco MA,Childers SR

    更新日期：1997-10-01 00:00:00

  • Microarray analysis of neural stem cell differentiation in the striatum of the fetal rat.

    abstract：:1. Gene expression profiles in neural stem cell differentiation in vitro were determined by cDNA microarray analysis. 2. Total RNA was extracted and reverse transcripted into cDNA from differentiated and undifferentiated neural stem cells. The 33P labeled cDNA was hybridized with a cDNA microarray consisting of 14,000...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1021059520618

    authors： Wen T,Gu P,Minning TA,Wu Q,Liu M,Chen F,Liu H,Huang H

    更新日期：2002-08-01 00:00:00

  • Pentosan polysulfate regulates scavenger receptor-mediated, but not fluid-phase, endocytosis in immortalized cerebral endothelial cells.

    abstract：:1. Effects of pentosan polysulfate (PPS) and the structurally related sulfated polyanions dextran sulfate, fucoidan, and heparin on the scavenger receptor-mediated and fluidphase endocytosis in GP8 immortalized rat brain endothelial cells were investigated. 2. Using 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarboxyamin...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007007026500

    authors： Deli MA,Abrahám CS,Takahata H,Katamine S,Niwa M

    更新日期：2000-12-01 00:00:00

  • Multiple mechanisms of antagonism of gamma-aminobutyric acid (GABA) responses.

    abstract：:Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters in the brain. In an effort to understand the operation of the GABA receptor-ionophore complex, the antagonism of GABA responses by four substances was studied in bullfrog dorsal root ganglion cells by concentration-clamp and internal-perfusi...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00734993

    authors： Akaike N,Yakushiji T,Tokutomi N,Carpenter DO

    更新日期：1987-03-01 00:00:00

  • Cholinesterases during development of the avian nervous system.

    abstract：:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly acc...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00712798

    authors： Layer PG

    更新日期：1991-02-01 00:00:00

  • Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

    abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-019-00676-6

    authors： Pozdnyakova N,Dudarenko M,Borisova T

    更新日期：2019-07-01 00:00:00

  • Neural Regulation of the Stress Response: The Many Faces of Feedback.

    abstract：:The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immedia...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-012-9801-y

    authors： Myers B,McKlveen JM,Herman JP

    更新日期：2012-02-01 00:00:00

  • Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR1-Dependent Potentiation After Pentylenetetrazole-Induced Acute Seizures in Young Rats.

    abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-018-00647-3

    authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

    更新日期：2019-03-01 00:00:00

  • RhoC involved in the migration of neural stem/progenitor cells.

    abstract：:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0026-0

    authors： Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

    更新日期：2014-04-01 00:00:00

  • EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.

    abstract：:EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease. Howev...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0287-2

    authors： Ni H,Shen J,Song Y,Cao M,Liu X,Huang J,Zhang W,Xie L,Ning X,Ke K

    更新日期：2016-08-01 00:00:00

  • Experimental evidence that methylmalonic acid provokes oxidative damage and compromises antioxidant defenses in nerve terminal and striatum of young rats.

    abstract：:Methylmalonic acidemia and propionic acidemia are organic acidemias biochemically characterized by predominant tissue accumulation of methylmalonic acid (MMA) and propionic acid (PA), respectively. Affected patients present predominantly neurological symptoms, whose pathogenesis is not yet fully established. In the pr...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-011-9675-4

    authors： Fernandes CG,Borges CG,Seminotti B,Amaral AU,Knebel LA,Eichler P,de Oliveira AB,Leipnitz G,Wajner M

    更新日期：2011-07-01 00:00:00

  • Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.

    abstract：:1. The aims of the present study were (a) to determine the identity of the G proteins with which the endothelin receptor interacts and whether this interaction is subtype specific and (b) to determine whether agonist exposure can result in specific coupling between the endothelin receptor and G proteins. 2. Coupling b...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007010125316

    authors： Shraga-Levine Z,Sokolovsky M

    更新日期：2000-06-01 00:00:00

  • Expression and induction of secretory phospholipase A2 group IB in brain.

    abstract：:Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and cha...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-005-8221-7

    authors： Kolko M,Christoffersen NR,Varoqui H,Bazan NG

    更新日期：2005-11-01 00:00:00

  • Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: interaction in the recognition of endothelin-1 between ETA and ETB receptors.

    abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1022557717481

    authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

    更新日期：1998-08-01 00:00:00

  • Expression of MCP-1 in the hippocampus of SHRSP with ischemia-related delayed neuronal death.

    abstract：:1. The expression of monocyte chemoattractant protein-1 (MCP-1) was examined in stroke-prone spontaneously hypertensive rats with transient global ischemia in order to study the involvement of the infiltration of blood monocytes in the mechanism of ischemia-related neuronal death. 2. The brains of the animals with occ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9077-1

    authors： Sakurai-Yamashita Y,Shigematsu K,Yamashita K,Niwa M

    更新日期：2006-07-01 00:00:00

  • Axonal contribution to subthreshold currents in Aplysia bursting pacemaker neurons.

    abstract：:The contribution of axonal activity to the ionic currents which generate bursting pacemaker activity was studied by using the two-electrode voltage-clamp technique in Aplysia bursting neuron somata in conjunction with intraaxonal voltage recordings. Depolarizing voltage-clamp pulses applied to bursting cell somata tri...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00711111

    authors： Kramer RH

    更新日期：1986-09-01 00:00:00

  • Complexity of Compensatory Effects in Nrf1 Knockdown: Linking Undeveloped Anxiety-Like Behavior to Prevented Mitochondrial Dysfunction and Oxidative Stress.

    abstract：:Anxiety-related disorders are complex illnesses that underlying molecular mechanisms need to be understood. Mitochondria stand as an important link between energy metabolism, oxidative stress, and anxiety. The nuclear factor, erythroid-derived 2,-like 1(Nrf1) is a member of the cap "n" collar subfamily of basic region...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0236-0

    authors： Khalifeh S,Oryan S,Khodagholi F,Digaleh H,Shaerzadeh F,Maghsoudi N,Zarrindast MR

    更新日期：2016-05-01 00:00:00

  • Differential suppression of axoplasmic transport: effects of light irradiation to the growth cone of cultured dorsal root ganglion neurons.

    abstract：:1. Growth cones of cultured dorsal root ganglion neurons from mice were irradiated using a mercury lamp. 2. The flux of particles of fast retrograde axoplasmic transport decreased promptly after light irradiation without a change in velocity. 3. That of anterograde transport decreased as well, but with a significant l...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02089941

    authors： Kano M,Tashiro H,Kawakami T,Takenaka T,Gotoh H

    更新日期：1995-06-01 00:00:00

  • Dopamine regulation of neurite outgrowth from identified Lymnaea neurons in culture.

    abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02152058

    authors： Spencer GE,Lukowiak K,Syed NI

    更新日期：1996-10-01 00:00:00

  • Deficiency in endothelin receptor B reduces proliferation of neuronal progenitors and increases apoptosis in postnatal rat cerebellum.

    abstract：:Endothelins regulate cellular functions in the mammalian brain through the endothelin receptors A and B (EDNRA and EDNRB). In this study, we investigated the role of EDNRB on cell proliferation in the cerebellum by using the spotting lethal (sl) rat, which carries a naturally occurring deletion in the EDNRB gene. Prol...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-008-9292-z

    authors： Vidovic M,Chen MM,Lu QY,Kalloniatis KF,Martin BM,Tan AH,Lynch C,Croaker GD,Cass DT,Song ZM

    更新日期：2008-12-01 00:00:00

  • The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro.

    abstract：:1. The electrophysiological actions of excitatory amino acids and serotonin were investigated in slices from cat neocortex in vitro. Intracellular recordings were obtained from neurons (mainly in layer V) and the drugs applied extracellularly to the same neurons by microiontophoresis. 2. Serotonin, and to some extent ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00733789

    authors： Nedergaard S,Engberg I,Flatman JA

    更新日期：1987-12-01 00:00:00

  • The effect of nimodipine on calcium homeostasis and pain sensitivity in diabetic rats.

    abstract：:1. The pathogenesis of diabetic neuropathy is a complex phenomenon, the mechanisms of which are not fully understood. Our previous studies have shown that the intracellular calcium signaling is impaired in primary and secondary nociceptive neurons in rats with streptozotocin (STZ)-induced diabetes. Here, we investigat...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9107-z

    authors： Shutov L,Kruglikov I,Gryshchenko O,Khomula E,Viatchenko-Karpinski V,Belan P,Voitenko N

    更新日期：2006-10-01 00:00:00

  • Effect of cholinomimetics on the release and uptake of L-[3H] glutamic acid in rat neostriatum.

    abstract：:The effects of cholinomimetics on the release and uptake of L-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro). Cholinomimetics regulate the release of L-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors accord...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00710999

    authors： Godukhin OV,Budantsev AYu,Selifanova OV,Agapova VN

    更新日期：1984-06-01 00:00:00

  • Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.

    abstract：:1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/b:cemn.0000005321.11544.cc

    authors： Chiu R,Rey O,Zheng JQ,Twiss JL,Song J,Pang S,Yokoyama KK

    更新日期：2003-12-01 00:00:00