Combination of dexamethasone and aminoguanidine reduces secondary damage in compression spinal cord injury.

Abstract:

:The study was performed to investigate the effect of combination therapy with aminoguanidine (AG) and dexamethasone (DEX) on the compression spinal cord injury (SCI) in rat. Compared to the control group, the combination therapy group with AG (75 mg/kg) and DEX (0.025 mg/kg) significantly reduced the degree of (1) spinal cord edema, (2) the permeability of blood spinal cord barrier (measured by (99m)Tc-Albumin), (3) infiltration of neutrophils (MPO evaluation), (4) cytokines expression (tumor necrosis factor-alpha and interleukin-1 beta), and (5) apoptosis (measured by Bax and Bcl-2 expression). In addition, we have also clearly demonstrated that the combination therapy significantly ameliorated the recovery of limb function (evaluated by motor recovery score). Taken together, our results clearly indicated for the first time that strategies targeting multiple proinflammatory pathways may be more effective than a single effector molecule for the treatment of SCI.

journal_name

Cell Mol Neurobiol

authors

Xu WB,Lv G,Wang YF,Lu XH,Huang T,Zhu Y,Jia LS

doi

10.1007/s10571-009-9380-8

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

683-9

issue

5

eissn

0272-4340

issn

1573-6830

journal_volume

29

pub_type

杂志文章
  • Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats.

    abstract::1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/b:cemn.0000022769.44211.2b

    authors: Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

    更新日期:2004-06-01 00:00:00

  • Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.

    abstract::1. The aims of the present study were (a) to determine the identity of the G proteins with which the endothelin receptor interacts and whether this interaction is subtype specific and (b) to determine whether agonist exposure can result in specific coupling between the endothelin receptor and G proteins. 2. Coupling b...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1007010125316

    authors: Shraga-Levine Z,Sokolovsky M

    更新日期:2000-06-01 00:00:00

  • Increased dithiothreitol-insensitive, type 2 angiotensin II receptors in selected brain areas of young rats.

    abstract::1. Angiotensin II receptors have been studied by quantitative autoradiography in selected brain areas of young (2-week-old) and adult (8-week-old) rats. 2. In young rats, angiotensin II receptors were present in brain areas which did not express receptors in the adult brain, such as thalamic nuclei, cortical areas, an...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00769042

    authors: Tsutsumi K,Saavedra JM

    更新日期:1991-04-01 00:00:00

  • Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage.

    abstract::The hematopoietic cell kinase (Hck) is a member of the Src family protein kinases which regulates many signal transduction pathways including cell growth, proliferation, differentiation, migration, and apoptosis. However, the expression and function of Hck after intracerebral hemorrhage (ICH) are unknown. Western blot...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0365-0

    authors: Wang J,Chen R,Liu X,Shen J,Yan Y,Gao Y,Tao T,Shi J

    更新日期:2017-03-01 00:00:00

  • Prevention of death of axotomized hypoglossal neurones and promotion of regeneration by chitin grafting.

    abstract::1. Chitin is known to promote skin wound healing. In this study, chitin, prepared from Zuwai crab shell, was used as a bridge between the proximal and distal stumps of cut hypoglossal nerves in shrews. We compared the effects of chitin on the regeneration of transected right hypoglossal nerve axons, with those of porc...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1007055626632

    authors: Itoh M,Izumi S,Uemura M,Baba N,Suyama K,Kuga Y,Mizuno A,Nakane PK,Koji T

    更新日期:2000-10-01 00:00:00

  • Molecular pharmacological dissection of short- and long-term memory.

    abstract::1. It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTM intact for the same task in the same animal. 2. The effect of a lar...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1020715800956

    authors: Izquierdo LA,Barros DM,Vianna MR,Coitinho A,deDavid e Silva T,Choi H,Moletta B,Medina JH,Izquierdo I

    更新日期:2002-06-01 00:00:00

  • Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme.

    abstract::An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent pas...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-020-00925-z

    authors: Tiwari RK,Singh S,Gupta CL,Bajpai P

    更新日期:2020-07-20 00:00:00

  • Fenamates Inhibit Human Sodium Channel Nav1.2 and Protect Glutamate-Induced Injury in SH-SY5Y Cells.

    abstract::Voltage-gated sodium channels are crucial mediators of neuronal damage in ischemic and excitotoxicity disease models. Fenamates have been reported to have anti-inflammatory properties following a decrease in prostaglandin synthesis. Several researches showed that fenamates appear to be ion channel modulators and poten...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-020-00826-1

    authors: Sun JF,Zhao MY,Xu YJ,Su Y,Kong XH,Wang ZY

    更新日期:2020-11-01 00:00:00

  • Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.

    abstract::Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypert...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9600-2

    authors: Chen Y,Rao F,Wen G,Gayen JR,Zhang K,Vaingankar SM,Biswas N,Mahata M,Friese RS,Fung MM,Salem RM,Nievergelt C,Bhatnagar V,Hook VY,Ziegler MG,Mahata SK,Hamilton BA,O'Connor DT

    更新日期:2010-11-01 00:00:00

  • Effect of Induction Time on the Proliferation and Differentiation of Induced Schwann-Like Cells from Adipose-Derived Stem Cells.

    abstract::To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-020-00795-5

    authors: Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

    更新日期:2020-10-01 00:00:00

  • Enhanced Neuroprotection of Minimally Invasive Surgery Joint Local Cooling Lavage against ICH-induced Inflammation Injury and Apoptosis in Rats.

    abstract::Hypothermia treatment is one of the neuroprotective strategies that improve neurological outcomes effectively after brain damage. Minimally invasive surgery (MIS) has been an important treatment of intracerebral hemorrhage (ICH). Herein, we evaluated the neuroprotective effect and mechanism of MIS joint local cooling ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-015-0245-z

    authors: Liu XC,Jing LY,Yang MF,Wang K,Wang Y,Fu XY,Fang J,Hou YJ,Sun JY,Li DW,Zhang ZY,Mao LL,Tang YM,Fu XT,Fan CD,Yang XY,Sun BL

    更新日期:2016-07-01 00:00:00

  • The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons.

    abstract::We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9288-8

    authors: Xiang H,Tao W,Wang L,Wang F,Xu A

    更新日期:2008-12-01 00:00:00

  • Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.

    abstract::Neuropathic pain occurs as a result of peripheral or central nervous system injury. Its pathophysiology involves mainly a central sensitization mechanism that may be correlated to many molecules acting in regions involved in pain processing, such as the spinal cord. It has been demonstrated that reactive oxygen specie...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9279-9

    authors: Guedes RP,Araújo AS,Janner D,Belló-Klein A,Ribeiro MF,Partata WA

    更新日期:2008-12-01 00:00:00

  • Altering cellular signaling pathways enhance gene silencing activity of shRNA, shRNA.ribozyme, and shRNA.antisense in neuroblastoma cells.

    abstract::1. RNA interference (RNAi) is a multicomponent machinery that operates in a sequence-specific manner to repress the expression of genes in most eukaryotic cells. 2. Here we wanted to investigate in a murine neuroblastoma cell line (NBP2) (a) if replacement of the loop of the short hairpin RNA (shRNA) with a hammerhead...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-004-6919-6

    authors: Nahreini P,Hanson AJ,Andreatta CP,Koustas WT,Prasad KN

    更新日期:2004-12-01 00:00:00

  • Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation.

    abstract::Smoking is a risk factor for dementia. Cognitive function can be partially restored after quitting smoking, but still lower than never smoked group. The underlying mechanisms still remain unclear. The effects of smoking cessation combined with cerebral chronic hypoperfusion (CCH) on cognitive function have never been ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-020-00992-2

    authors: Meng N,Dong Y,Huo T,Song M,Jiang X,Xiao Y,Lv P

    更新日期:2020-11-06 00:00:00

  • Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles.

    abstract:AIM:A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS:Electron microscop...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-007-9156-y

    authors: Sombers LA,Maxson MM,Ewing AG

    更新日期:2007-08-01 00:00:00

  • Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.

    abstract::Somatostatin which is a multifunctional growth hormone inhibitory neuropeptide shows diverse physiological effects, such as neurotransmission, cell growth, apoptosis, and endocrine signaling as well as exerts inhibitory effects on hormonal products and other secretory proteins. SSTR3 is a member of superfamily of soma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-017-0471-7

    authors: Yao Q,Liu Q,Xu H,Wu Z,Zhou L,Gu Z,Gong P,Shen J

    更新日期:2017-11-01 00:00:00

  • Estrogen control of central neurotransmission: effect on mood, mental state, and memory.

    abstract::1. Estrogen exerts profound effects on mood, mental state and memory by acting on both "classical" monoamine and neuropeptide transmitter mechanisms in brain. Here we review an example of each type of action. 2. With respect to the effect of estrogen on central monoamine neurotransmission, low levels of estrogen in wo...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02088099

    authors: Fink G,Sumner BE,Rosie R,Grace O,Quinn JP

    更新日期:1996-06-01 00:00:00

  • Molecular interactions between the photoreceptor G protein and rhodopsin.

    abstract::1. The visual transduction system of the vertebrate retina is a well-studied model for biochemical and molecular studies of signal transduction. The structure and function of rhodopsin, a prototypical G protein-coupled receptor, and transducin or Gt, the photoreceptor G protein, have been particularly well studied. Me...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00741446

    authors: Hamm HE

    更新日期:1991-12-01 00:00:00

  • Evolutionary aspects of gonadotropin-releasing hormone and its receptor.

    abstract::1. Gonadotropin-releasing hormone (GnRH) was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, during evolution the peptide was subject to gene duplication and structural changes, and multiple m...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02069556

    authors: King JA,Millar RP

    更新日期:1995-02-01 00:00:00

  • The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.

    abstract::In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin MVIIA and xconotoxin MVIIC, only inhibited calcium-dependent glutamate release. PhTx3-4, but not ω-conotoxin MVIIA or ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9618-5

    authors: Gonçaves JM,Ferreira J,Prado MA,Cordeiro MN,Richardson M,Pinheiro AC,Silva MA,Junior CJ,Souza AH,Gomez MV

    更新日期:2011-03-01 00:00:00

  • pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.

    abstract::Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0359-y

    authors: Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

    更新日期:2017-03-01 00:00:00

  • Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury.

    abstract::(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for these effects are unknown. (2) The present study analyzed morphological changes in motoneurons distal to the lesion site from rats with or without progesterone t...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9291-0

    authors: González SL,López-Costa JJ,Labombarda F,González Deniselle MC,Guennoun R,Schumacher M,De Nicola AF

    更新日期:2009-02-01 00:00:00

  • Aquaporin-mediated fluid regulation in the inner ear.

    abstract::1. The sensory functions of the inner ear (hearing and balance) critically depend on the precise regulation of two fluid compartments of highly desparate ion composition, i.e., the endolymph and the perilymph. 2. The parameters volume, ion composition, and pH need to be held at homeostasis irrespective of the hydratio...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1023636620721

    authors: Beitz E,Zenner HP,Schultz JE

    更新日期:2003-06-01 00:00:00

  • Mice with disrupted TGFbeta signaling have normal cerebella development, but exhibit facial dysmorphogenesis and strain-dependent deficits in their body wall.

    abstract::The transforming growth factor betas (TGFbetas) are context-dependent regulators of neurons in vitro, but their physiological functions in the brain are unclear. Haploinsufficiency of either Tgfbeta1 or Tgfbeta2 leads to age-related deterioration of neurons, but the development of the brain is normal in the full absen...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9354-x

    authors: Asano Y,Koishi K,Frugier T,McLennan IS

    更新日期:2009-07-01 00:00:00

  • Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons.

    abstract::1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00711557

    authors: Stefano GB,Sawada M,Smith EM,Hughes TK

    更新日期:1993-12-01 00:00:00

  • Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats.

    abstract::Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-015-0209-3

    authors: Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

    更新日期:2015-11-01 00:00:00

  • Differential suppression of axoplasmic transport: effects of light irradiation to the growth cone of cultured dorsal root ganglion neurons.

    abstract::1. Growth cones of cultured dorsal root ganglion neurons from mice were irradiated using a mercury lamp. 2. The flux of particles of fast retrograde axoplasmic transport decreased promptly after light irradiation without a change in velocity. 3. That of anterograde transport decreased as well, but with a significant l...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF02089941

    authors: Kano M,Tashiro H,Kawakami T,Takenaka T,Gotoh H

    更新日期:1995-06-01 00:00:00

  • Opioid effects in developing rat vas deferens.

    abstract::The inhibitory effects of various opiates on developing rat vas deferens were studied by determining the degree of depression of mechanical responses elicited by electrical field stimulation. All agonists showed decreased effects with maturation, but the decrease occurred at different times. With normorphine the loss ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00716268

    authors: Rónai AZ,Berzétei IP,Kurgyis J

    更新日期:1981-12-01 00:00:00

  • Effects of adrenocortical steroids on long-term potentiation in the limbic system: basic mechanisms and behavioral consequences.

    abstract::Hippocampal structures are a major target for adrenal steroid hormones, and hence these neural regions are some of the most likely mediators of the effects of adrenocortical steroids on behavior. Memory disturbance, in particular biasing toward negative contents, are part of the symptomatology presented by depressive ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00711580

    authors: Dubrovsky B,Gijsbers K,Filipini D,Birmingham MK

    更新日期:1993-08-01 00:00:00