Abstract:
:Both sex and steroid hormones are important to consider in human ischemic stroke and its experimental models. Stroke initiates a cascade of changes that lead to neural cell death, but also activates endogenous protective processes that counter the deleterious consequences of ischemia. Steroids may be part of these cerebroprotective processes. One option to provide cerebroprotection is to reinforce these intrinsic protective mechanisms. In the current review, we first summarize studies describing sex differences and the influence of steroid hormones in stroke. We then present and discuss our recent results concerning differential changes in endogenous steroid levels in the brains of male and female mice and the importance of progesterone receptors (PR) during the early phase after stroke. In the third part, we give an overview of experimental studies, including ours, that provide evidence for the pleiotropic beneficial effects of progesterone and its promising cerebroprotective potential in stroke. We also highlight the key role of PR signaling as well as potential additional mechanisms by which progesterone may provide cerebroprotection.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Guennoun R,Zhu X,Fréchou M,Gaignard P,Slama A,Liere P,Schumacher Mdoi
10.1007/s10571-018-0627-0subject
Has Abstractpub_date
2019-05-01 00:00:00pages
551-568issue
4eissn
0272-4340issn
1573-6830pii
10.1007/s10571-018-0627-0journal_volume
39pub_type
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