当前位置： SCI文献检索 > CELLULAR AND MOLECULAR NEUROBIOLOGY期刊下所有文献 > Alteration of DBP levels in CSF of patients with MS by proteomics analysis.

Alteration of DBP levels in CSF of patients with MS by proteomics analysis.

Abstract：

OBJECTIVE:The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study. METHODS:First, the proteins of CSF from MS patients and control group were analyzed individually with 2D-DIGE technology (two-dimensional difference gel electrophoresis). Then, protein spots were found out with DeCyder6.0 software which showed different expression levels in the gel images between the two groups. The information regarding these proteins was collected based on MALDI-TOF/MS and related database searches. Lastly, interaction between these proteins was further analyzed by using Metacore software. RESULTS:There were 13 proteins that showed more than 1.5-fold difference in expression levels between the two groups. Furthermore, the identification made by MALDI-TOF/MS revealed that one of the most significant differential proteins was DBP (vitamin D-binding protein), which decreased in the experimental group. This result was confirmed by ELISA (P < 0.01). Moreover, network between the 13 proteins were partially got, which showed some biological interactions. CONCLUSION:These results support a correlation between the level of DBP and MS. DBP may be a potential useful biomarker for diagnosis or a medicine target for treatment of MS.

journal_name

Cell Mol Neurobiol

journal_title

Cellular and molecular neurobiology

authors

Qin Z,Qin Y,Liu S

doi

10.1007/s10571-008-9312-z

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

203-10

issue

2

eissn

0272-4340

issn

1573-6830

journal_volume

29

pub_type

杂志文章

相关文献

CELLULAR AND MOLECULAR NEUROBIOLOGY文献大全
  • The rate of Tau synthesis is differentially regulated during postnatal development in mouse cerebellum.

    abstract：:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1013823524302

    authors： Vilá-Ortiz GJ,Santa-Coloma TA,Carminatti H,Radrizzani M

    更新日期：2001-10-01 00:00:00

  • Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.

    abstract：:Somatostatin which is a multifunctional growth hormone inhibitory neuropeptide shows diverse physiological effects, such as neurotransmission, cell growth, apoptosis, and endocrine signaling as well as exerts inhibitory effects on hormonal products and other secretory proteins. SSTR3 is a member of superfamily of soma...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-017-0471-7

    authors： Yao Q,Liu Q,Xu H,Wu Z,Zhou L,Gu Z,Gong P,Shen J

    更新日期：2017-11-01 00:00:00

  • Altered Sodium and Potassium, but not Calcium Currents in Cerebellar Granule Cells in an In Vitro Model of Neuronal Injury.

    abstract：:Acute injury of central nervous system (CNS) starts a cascade of morphological, molecular, and functional changes including formation of a fibrotic scar, expression of transforming growth factor beta 1 (TGF-β1), and expression of extracellular matrix proteins leading to arrested neurite outgrowth and failed regenerati...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-016-0416-6

    authors： Ondáčová K,Jurkovičová D,Lacinová Ľ

    更新日期：2017-07-01 00:00:00

  • Endogenous dopamine maintains synchronous oscillation of intracellular calcium in primary cultured-mouse midbrain neurons.

    abstract：:We demonstrated synchronous oscillation of intracellular Ca2+ in cultured-mouse mid-brain neurons. This synchronous oscillation was thought to result from spontaneous and synchronous neural bursts in a synaptic neural network. We also examined the role of endogenous dopamine in neural networks showing synchronous osci...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/b:cemn.0000012724.79184.b6

    authors： Yasumoto F,Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

    更新日期：2004-02-01 00:00:00

  • Glutamic acid decarboxylase of embryonic avian retina cells in culture: regulation by gamma-aminobutyric acid (GABA).

    abstract：:1. Retina-cell aggregate cultures expressed glutamate decarboxylase activity (L-glutamate 1-carboxylase; EC 4.1.1.15) as a function of culture differentiation. 2. Glutamic acid decarboxylase (GAD) activity was low in the initial phases of culture and increased eight-fold until culture day 7, remaining high up to day 1...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00734811

    authors： de Mello FG,Hokoç JN,Ventura AL,Gardino PF

    更新日期：1991-10-01 00:00:00

  • Characterization of NO/cGMP-mediated responses in identified motoneurons.

    abstract：:1. Nitric oxide (NO) is thought to play a neuromodulatory role in the nervous system of vertebrate and invertebrate species. In the hornworm Manduca sexta, NO-mediated signaling has been implicated in behavioral and developmental processes, but its exact function in neurons is unknown. In this study, we identify speci...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9091-3

    authors： Zayas RM,Trimmer BA

    更新日期：2007-03-01 00:00:00

  • Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw.

    abstract：:1. Doubly transgenic mice were some differences in the period proceeding of the development of Abeta-42 deposits and behavioral deficits. It was not characterized human mutant PS2 (hPS2) with APPsw in the brains of double transgenic mice. The aim of this study was to examine whether doubly transgenic mice co-expressin...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-005-4950-x

    authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Song CW,Lee SH,Kim YK

    更新日期：2005-08-01 00:00:00

  • Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.

    abstract：:The myelin-associated inhibitor/Nogo-66 receptor 1 (NgR1) pathway directly functions in negative modulation of structural and electrophysiological synaptic plasticity. A previous study has established an important role of NgR1 pathway signaling in cognitive function, and we have demonstrated that multiple components o...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-9929-4

    authors： VanGuilder Starkey HD,Bixler GV,Sonntag WE,Freeman WM

    更新日期：2013-05-01 00:00:00

  • Comparison of the neural differentiation potential of human mesenchymal stem cells from amniotic fluid and adult bone marrow.

    abstract：:Human mesenchymal stem cells (MSCs) are considered a promising tool for cell-based therapies of nervous system diseases. Bone marrow (BM) has been the traditional source of MSCs (BM-MSCs). However, there are some limitations for their clinical use, such as the decline in cell number and differentiation potential with ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-9922-y

    authors： Yan ZJ,Hu YQ,Zhang HT,Zhang P,Xiao ZY,Sun XL,Cai YQ,Hu CC,Xu RX

    更新日期：2013-05-01 00:00:00

  • Expression of P2X3 and P2X 5 myenteric receptors varies during the intestinal postnatal development in the guinea pig.

    abstract：:P2X3 receptor expression in various tissues appears to be modulated by age. In the present study, we used single cell RT-PCR to determine the number of P2X3 positive myenteric neurons at different stages of guinea pig postnatal development, and we tested if similar changes also occur to other myenteric P2X receptors. ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0055-8

    authors： Loera-Valencia R,Jiménez-Vargas NN,Villalobos EC,Juárez EH,Lomas-Ramos TL,Espinosa-Luna R,Montaño LM,Huizinga JD,Barajas-López C

    更新日期：2014-07-01 00:00:00

  • Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells.

    abstract：:Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-019-00668-6

    authors： Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

    更新日期：2019-07-01 00:00:00

  • Divalent cation effects on acetylcholine-activated channels at the frog neuromuscular junction.

    abstract：:The effects of the divalent cations Ca and Mg on the properties of ACh-activated channels at the frog neuromuscular junction were studied using a two-microelectrode voltage clamp. The divalent cation concentration was varied from 2 to 40 mM in solutions containing 50% normal Na. The reversal potential was determined b...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00733590

    authors： Lewis CA

    更新日期：1984-09-01 00:00:00

  • Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia.

    abstract：:To clarify the role of angiotensin II (Ang II) in the regulation of sensory signaling, we studied the effect of subpressor dose (150 ng/kg/min) of Ang II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) after chronic constriction...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-9934-7

    authors： Pavel J,Oroszova Z,Hricova L,Lukacova N

    更新日期：2013-07-01 00:00:00

  • Pentosan polysulfate regulates scavenger receptor-mediated, but not fluid-phase, endocytosis in immortalized cerebral endothelial cells.

    abstract：:1. Effects of pentosan polysulfate (PPS) and the structurally related sulfated polyanions dextran sulfate, fucoidan, and heparin on the scavenger receptor-mediated and fluidphase endocytosis in GP8 immortalized rat brain endothelial cells were investigated. 2. Using 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarboxyamin...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007007026500

    authors： Deli MA,Abrahám CS,Takahata H,Katamine S,Niwa M

    更新日期：2000-12-01 00:00:00

  • The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons.

    abstract：:We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-008-9288-8

    authors： Xiang H,Tao W,Wang L,Wang F,Xu A

    更新日期：2008-12-01 00:00:00

  • Expression Profiling of DNA Methylation and Transcriptional Repression Associated Genes in Lens Epithelium Cells of Age-Related Cataract.

    abstract：:In our previous research, the formation and development of age-related cataract (ARC) is associated with DNA hypermethylation of some genes in lens epithelial cells (LECs). This study aimed to investigate the expression profile of DNA methylation- and transcriptional repression-associated genes in LECs of ARC. The exp...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-016-0393-9

    authors： Wang Y,Zhang G,Kang L,Guan H

    更新日期：2017-04-01 00:00:00

  • Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.

    abstract：:Endothelins have been implicated in the regulation of cell proliferation, differentiation, and apoptosis, but the mechanisms of these complex events are not yet fully understood. Although the nuclear factor-kappaB (NF-kappaB) was shown to play a prominent role in the above processes, its participation in endothelin re...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1015195803445

    authors： Mangelus M,Galron R,Naor Z,Sokolovsky M

    更新日期：2001-12-01 00:00:00

  • A quantum dot probe conjugated with aβ antibody for molecular imaging of Alzheimer's disease in a mouse model.

    abstract：:The treatment of Alzheimer's disease (AD) has been hampered by a lack of sensitive and specific non-invasive diagnostic methods. Quantum dots (QD) are nano-crystals with unique photo-physical properties that bypass some of the limitations of conventional dyes and imaging tools. This study is aimed to evaluate the fluo...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-9943-6

    authors： Feng L,Long HY,Liu RK,Sun DN,Liu C,Long LL,Li Y,Chen S,Xiao B

    更新日期：2013-08-01 00:00:00

  • Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats.

    abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-015-0209-3

    authors： Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

    更新日期：2015-11-01 00:00:00

  • Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.

    abstract：:The P2X4 receptor (P2X4R) is a member of a family of ATP-gated cation channels that are composed of three subunits. Each subunit has two transmembrane (TM) domains linked by a large extracellular loop and intracellularly located N- and C-termini. The receptors are expressed in excitable and non-excitable cells and hav...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-010-9568-y

    authors： Stojilkovic SS,Yan Z,Obsil T,Zemkova H

    更新日期：2010-11-01 00:00:00

  • Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress.

    abstract：:1. The role of oxidative stress, and accordingly uncontrolled reactive oxygen species generation/action, have been widely documented in a number of different neuronal pathologies. However, the concept of pharmacological interventions in prevention and therapy of oxidative stress-related diseases has not found adequate...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9037-9

    authors： Stolc S,Snirc V,Májeková M,Gáspárová Z,Gajdosíková A,Stvrtina S

    更新日期：2006-10-01 00:00:00

  • Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development.

    abstract：:(1) A Little information exists on the distribution of Slit-Robo-GTPase activating proteins (srGAPs), particularly about their intracellular locations, which may provide further clues to their functions. The purpose of this study is to elucidate the expression patterns of the three srGAPs in wild-type rat brains at ad...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-007-9187-4

    authors： Yao Q,Jin WL,Wang Y,Ju G

    更新日期：2008-02-01 00:00:00

  • Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture.

    abstract：:1. Alpha-synuclein is known to play an important role in the pathogenesis of Parkinson's disease (PD). The pathogenicity of alpha-synuclein is related to its ability to form intraneuronal inclusions. The inclusions, which are found in brains of patients with PD and diffuse Lewy body disease consist partially of C-term...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-007-9141-5

    authors： Zach S,Bueler H,Hengerer B,Gillardon F

    更新日期：2007-06-01 00:00:00

  • VAT-1 from Torpedo synaptic vesicles is a calcium binding protein: a study in bacterial expression systems.

    abstract：:1. Calcium binding properties were examined in VAT-1, an abundant 41-kDa membrane protein expressed in the cholinergic cynaptic vesicles of Torpedo. 2. An overlay assay, using 45Ca2+ as a tracer, demonstrated the ability of a recombinant VAT-1 produced from the IPTG-inducible pKK223-3 expression vector to bind calcium...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00711457

    authors： Levius O,Linial M

    更新日期：1993-10-01 00:00:00

  • Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.

    abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-019-00743-y

    authors： Rutigliano G,Zucchi R

    更新日期：2020-03-01 00:00:00

  • The mGluR5 positive allosteric modulator CDPPB inhibits SO₂-induced protein radical formation and mitochondrial dysfunction through activation of Akt in mouse hippocampal HT22 cells.

    abstract：:Sulfur dioxide (SO2) is a common gas pollutant that is detrimental to many organs. Previous studies have shown that SO2 exposure is involved in neurotoxicity and increased risk of many brain disorders; however, our understanding of the mechanisms underlying SO2-induced cytotoxicity on neuronal cells remains elusive. T...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0153-7

    authors： Guan DF,Ren PY,Hu W,Zhang YL

    更新日期：2015-05-01 00:00:00

  • Neuronal analysis and behaviour in prenatally gamma-irradiated rats.

    abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-014-0144-8

    authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

    更新日期：2015-01-01 00:00:00

  • Cholinergic signaling in the rat pineal gland.

    abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02073327

    authors： Laitinen JT,Laitinen KS,Kokkola T

    更新日期：1995-04-01 00:00:00

  • miR-9 Upregulation Integrates Post-ischemic Neuronal Survival and Regeneration In Vitro.

    abstract：:The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesi...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-018-0642-1

    authors： Nampoothiri SS,Rajanikant GK

    更新日期：2019-03-01 00:00:00

  • Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis.

    abstract：:1. Several intrinsically disordered proteins (IDPs) play principal role in the neurodegenerative processes of various types. Among them, alpha-synuclein is involved in Parkinson's disease, prion protein in transmissible spongiform encephalopathies, and tau protein in Alzheimer's disease (AD) and related tauopathies. N...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-006-9083-3

    authors： Skrabana R,Sevcik J,Novak M

    更新日期：2006-10-01 00:00:00