Abstract:
:1. Several intrinsically disordered proteins (IDPs) play principal role in the neurodegenerative processes of various types. Among them, alpha-synuclein is involved in Parkinson's disease, prion protein in transmissible spongiform encephalopathies, and tau protein in Alzheimer's disease (AD) and related tauopathies. Neuronal damage in AD is accompanied by the presence of tau protein fibrils composed of paired helical filaments (PHF). 2. Tau protein represents a typical IDP. IDPs do not exhibit any stable secondary structure in the free form, but they are able to fold after binding to targets and contain regions with large propensity to adopt a defined type of secondary structure. Binding-folding event at tau protein leading to PHF generation is believed to happen in the course of tauopathies. 3. Detailed molecular topology of PHF formation is unknown. There are evidences about the cross-beta structure in PHF core; however the precise arrangement of the tau polypeptide chain is unclear. In this review we summarize current attempts at in vitro PHF reconstruction and the development of methods for PHF structure determination. The emphasis is put on the monoclonal antibodies used as structural molecular probes for research on the role of IDPs in pathogenesis of neurodegenerative diseases.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Skrabana R,Sevcik J,Novak Mdoi
10.1007/s10571-006-9083-3subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1085-97issue
7-8eissn
0272-4340issn
1573-6830journal_volume
26pub_type
杂志文章,评审abstract::1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...
journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1023/b:cemn.0000005321.11544.cc
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abstract::1. Antidepressants have been used clinically for many years; however, the neurochemical mechanism for their therapeutic effect has not been clarified yet. Recent reports indicate that chronic antidepressant treatment directly affects the postsynaptic membrane to increase the coupling between the stimulatory GTP-bindin...
journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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doi:10.1007/s10571-006-9134-9
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s10571-020-00883-6
更新日期:2020-05-28 00:00:00
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journal_title:Cellular and molecular neurobiology
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doi:10.1007/s10571-009-9485-0
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02088678
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00711070
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00711228
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-016-0416-6
更新日期:2017-07-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00742977
更新日期:1986-03-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00712927
更新日期:1992-06-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-019-00655-x
更新日期:2019-04-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00734932
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-009-9458-3
更新日期:2010-04-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-013-0011-z
更新日期:2014-03-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-005-8468-z
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF00712930
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journal_title:Cellular and molecular neurobiology
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更新日期:2011-07-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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更新日期:2017-10-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1023/a:1025063811290
更新日期:2003-10-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-011-9672-7
更新日期:2011-08-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-019-00656-w
更新日期:2019-04-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1023/a:1020715800956
更新日期:2002-06-01 00:00:00