Abstract:
:1. Several weeks after administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia, a dark pigmentation appears in serotonin-containing neurons, and this pigmentation allows visual identification of serotonergic neurons but does not appear to alter their physiology. 2. We have determined the distribution of labeled nerve cell bodies in the various ganglia of Aplysia and have characterized the pigment containing structures in both control and labeled neurons. 3. All neurons in this preparation, whether or not they utilize serotonin as a transmitter, contain pigment granules, and three types of pigment granules can be distinguished. After 5,7-DHT a new type of granule appears in serotonergic neurons, probably reflecting lysosomes that have accumulated serotonergic synaptic vesicles that contain the oxidized 5,7-DHT. 4. It remains unclear why this substance does not cause neurotoxicity in mollusks as it does in mammalian preparations.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Hernádi L,Rózsa KS,Jahan-Parwar B,Carpenter DOdoi
10.1007/BF00734932subject
Has Abstractpub_date
1992-08-01 00:00:00pages
317-26issue
4eissn
0272-4340issn
1573-6830journal_volume
12pub_type
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