Decreased GABAA receptors functional regulation in the cerebral cortex and brainstem of hypoxic neonatal rats: effect of glucose and oxygen supplementation.

abstract：:Glial cells have various important roles in regulation of brain functions. For such events, extracellular nucleotides/P2 receptors have central roles. Although there have been huge amount of literature about activation of P2 receptors and glial functions, little is known about what happens in glia or the brain if glia...

journal_title：Cellular and molecular neurobiology

authors： Kinoshita M,Nasu-Tada K,Fujishita K,Sato K,Koizumi S

更新日期：2013-01-01 00:00:00

abstract：:: 1. Glutaric acidemia type I (GA I) is a neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase, which leads to tissue accumulation of predominantly glutaric acid (GA) and also 3-hydroxyglutaric acid to a lesser amount. Affected patients usually present progressive cortical atrophy and acute stria...

journal_title：Cellular and molecular neurobiology

authors： Latini A,Ferreira GC,Scussiato K,Schuck PF,Solano AF,Dutra-Filho CS,Vargas CR,Wajner M

更新日期：2007-06-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new p...

journal_title：Cellular and molecular neurobiology

authors： Fachel FNS,Dal Prá M,Azambuja JH,Endres M,Bassani VL,Koester LS,Henriques AT,Barschak AG,Teixeira HF,Braganhol E

更新日期：2020-01-01 00:00:00

abstract：:1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity. 2....

journal_title：Cellular and molecular neurobiology

authors： Guevara BH,Cespedes GC,Cubeddu LX

更新日期：2002-12-01 00:00:00

abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

journal_title：Cellular and molecular neurobiology

authors： Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

更新日期：2004-06-01 00:00:00

abstract：:1. We measured changes in resting membrane potential (Em) and Na-K pump activity, assayed by ouabain-sensitive 86Rb uptake, in response to carbamylcholine (CCh) and its continued presence in single rat skeletal myotubes in culture. 2. CCh caused immediate depolarization from control Em (-80 to -85 mV) to near 0 follow...

journal_title：Cellular and molecular neurobiology

authors： Brodie C,Sampson SR

更新日期：1988-12-01 00:00:00

abstract：:Phenylketonuria (PKU) is an inherited metabolic disorder caused by deficiency of phenylalanine hydroxylase which leads to accumulation of phenylalanine and its metabolites in tissues of patients with severe neurological involvement. Recently, many studies in animal models or patients have reported the role of oxidativ...

journal_title：Cellular and molecular neurobiology

authors： Moraes TB,Jacques CE,Rosa AP,Dalazen GR,Terra M,Coelho JG,Dutra-Filho CS

更新日期：2013-03-01 00:00:00

abstract：:We have screened new drugs with a view to developing effective drugs against glutamate-induced excitotoxicity. In the present work, we show effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against glutamate-induced excitotoxicity in primary rat glial cultures. Pretreatment of glial cells...

journal_title：Cellular and molecular neurobiology

authors： Kim EA,Hahn HG,Kim KS,Kim TU,Choi SY,Cho SW

更新日期：2010-07-01 00:00:00

abstract：:1. Gamma-aminobutryic acid (GABA), a major inhibitory transmitter of the vertebrate retina, is synthesized from glutamate by L-glutamate decarboxylase (GAD) and mediates neuronal inhibition at GABAA receptors. GAD consists of two distinct molecular forms, GAD65 and GAD67, which have similar distribution patterns in th...

journal_title：Cellular and molecular neurobiology

authors： Brecha NC,Sternini C,Humphrey MF

更新日期：1991-10-01 00:00:00

abstract：:1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

journal_title：Cellular and molecular neurobiology

authors： Meinertzhagen IA,Hu X

更新日期：1996-12-01 00:00:00

abstract：:In this study, we investigated the actions of high homocysteine (Hcy) levels (100 and 500 microM) on the cytoskeleton of C6 glioma cells. Results showed that the predominant cytoskeletal response was massive formation of actin-containing filopodia at the cell surface that could be related with Cdc42 activation and inc...

journal_title：Cellular and molecular neurobiology

authors： Loureiro SO,Heimfarth L,Lacerda BA,Vidal LF,Soska A,dos Santos NG,de Souza Wyse AT,Pessoa-Pureur R

更新日期：2010-05-01 00:00:00

abstract：:1. Growth cones of cultured dorsal root ganglion neurons from mice were irradiated using a mercury lamp. 2. The flux of particles of fast retrograde axoplasmic transport decreased promptly after light irradiation without a change in velocity. 3. That of anterograde transport decreased as well, but with a significant l...

journal_title：Cellular and molecular neurobiology

authors： Kano M,Tashiro H,Kawakami T,Takenaka T,Gotoh H

更新日期：1995-06-01 00:00:00

abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

journal_title：Cellular and molecular neurobiology

authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

更新日期：2010-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

journal_title：Cellular and molecular neurobiology

authors： Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

更新日期：2020-10-30 00:00:00

abstract：:The hypothesis that peripheral, skeletal muscle tissue contains a trophic factor supporting central neurons has recently been investigated in vitro by supplementing the culture medium of spinal cord neurons with muscle extracts and fractions of extract. We extended these studies asking whether or not a trophic factor ...

journal_title：Cellular and molecular neurobiology

authors： Popiela H,Porter T,Beach RL,Festoff BW

更新日期：1984-03-01 00:00:00

abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...

journal_title：Cellular and molecular neurobiology

authors： Saunders NR,Knott GW,Dziegielewska KM

更新日期：2000-02-01 00:00:00

abstract：:Ischemic preconditioning (IPC) represents an important adaptation of CNS to sub-lethal ischemia, which results in increased tolerance of CNS to the lethal ischemia. Ischemia-induced mitochondrial apoptosis is considered to be an important event leading to neuronal cell death after cerebral blood flow arrest. In presen...

journal_title：Cellular and molecular neurobiology

authors： Racay P,Chomova M,Tatarkova Z,Kaplan P,Hatok J,Dobrota D

更新日期：2009-09-01 00:00:00

abstract：:Pulsed radiofrequency (PRF) treatment involves the pulsed application of a radiofrequency electric field to a nerve. The technology offers pain relief for patients suffering from chronic pain who do not respond well to conventional treatments. We tested whether PRF treatment attenuated complete Freund's adjuvant (CFA)...

journal_title：Cellular and molecular neurobiology

authors： Chen KH,Yang CH,Juang SE,Huang HW,Cheng JK,Sheen-Chen SM,Cheng JT,Lin CR

更新日期：2014-03-01 00:00:00

abstract：:1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTP gamma S, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were st...

journal_title：Cellular and molecular neurobiology

authors： Heemskerk FM,Zorad S,Xu N,Gutkind SJ,Saavedra JM

更新日期：1999-04-01 00:00:00

abstract：:1. Examination of the cerebrospinal fluid (CSF) of head-injured patients reveals that the concentration of intraventricular xanthine is elevated and that of uridine is decreased relative to those of adult lumbar CSF. 2. No correlations were observed between CSF lactate and CSF hypoxanthine, xanthine, or uridine, sugge...

journal_title：Cellular and molecular neurobiology

authors： Mueller RA,Rosner MJ,Ghia JN,Powers SK,Kafer ER,Hunt RD

更新日期：1988-06-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:1. We describe here the alterations in the nociceptive sensitivity of Swiss CD1 mice receiving an intraplantar (i.pl.) administration of XC Rous sarcoma-virus-transformed rat fibroblasts (XC cells). 2. Histological studies reveal that XC cells remain at the injection site 2-3 weeks after implantation, a time at which ...

journal_title：Cellular and molecular neurobiology

authors： Baamonde A,Lastra A,Fresno MF,Llames S,Meana A,Hidalgo A,Menéndez L

更新日期：2004-04-01 00:00:00

abstract：:Glioma stem cells (GSCs) are thought to be critical for resistance to radiotherapy and chemotherapy and for tumor recurrence after surgery in glioma patients. Identification of new therapeutic strategies that can target GSCs may thus be critical for improving patient survival. MicroRNAs (miRNAs) are small non-coding R...

journal_title：Cellular and molecular neurobiology

authors： Chen L,Chen XR,Chen FF,Liu Y,Li P,Zhang R,Yan K,Yi YJ,Xu ZM,Jiang XD

更新日期：2013-07-01 00:00:00

abstract：:1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...

journal_title：Cellular and molecular neurobiology

authors： al-Hussain SM

更新日期：1992-06-01 00:00:00

abstract：:The inactivation process of the calcium current (ICa) was investigated in a molluscan neuron which was perfused intracellularly and voltage-clamped using a suction pipette technique. The decay phase of the ICa contained a very slowly inactivated component (persistent inward current; PIC). The decay time constant of th...

journal_title：Cellular and molecular neurobiology

authors： Oyama Y,Akaike N,Nishi K

更新日期：1986-03-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00

abstract：:Although Butylphthalide (BP) has protective effects that reduce ischemia-induced brain damage and neuronal cell death, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of BP against isch...

journal_title：Cellular and molecular neurobiology

authors： Wen XR,Tang M,Qi DS,Huang XJ,Liu HZ,Zhang F,Wu J,Wang YW,Zhang XB,Guo JQ,Wang SL,Liu Y,Wang YL,Song YJ

更新日期：2016-10-01 00:00:00

abstract：:Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

journal_title：Cellular and molecular neurobiology

authors： Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

更新日期：2017-03-01 00:00:00

abstract：:1. Gonadotropin-releasing hormone (GnRH) was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, during evolution the peptide was subject to gene duplication and structural changes, and multiple m...

journal_title：Cellular and molecular neurobiology

authors： King JA,Millar RP

更新日期：1995-02-01 00:00:00

abstract：:1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) ind...

journal_title：Cellular and molecular neurobiology

authors： Park KC,Shimizu K,Hayakawa T

更新日期：1998-10-01 00:00:00