Glutamic acid decarboxylase of embryonic avian retina cells in culture: regulation by gamma-aminobutyric acid (GABA).

abstract：:Cerebral hemorrhage is a series of devastating cerebrovascular diseases with high mortality, morbidity and recurrence rate. Localized and systemic immuno-reactions are involved. Aggregation of immunocytes, which were both recruited from the peripheral circulation and resident in the central nervous system, is induced ...

journal_title：Cellular and molecular neurobiology

authors： Ye L,Gao L,Cheng H

更新日期：2018-10-01 00:00:00

abstract：:Anxiety-related disorders are complex illnesses that underlying molecular mechanisms need to be understood. Mitochondria stand as an important link between energy metabolism, oxidative stress, and anxiety. The nuclear factor, erythroid-derived 2,-like 1(Nrf1) is a member of the cap "n" collar subfamily of basic region...

journal_title：Cellular and molecular neurobiology

authors： Khalifeh S,Oryan S,Khodagholi F,Digaleh H,Shaerzadeh F,Maghsoudi N,Zarrindast MR

更新日期：2016-05-01 00:00:00

abstract：:In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin MVIIA and xconotoxin MVIIC, only inhibited calcium-dependent glutamate release. PhTx3-4, but not ω-conotoxin MVIIA or ...

journal_title：Cellular and molecular neurobiology

authors： Gonçaves JM,Ferreira J,Prado MA,Cordeiro MN,Richardson M,Pinheiro AC,Silva MA,Junior CJ,Souza AH,Gomez MV

更新日期：2011-03-01 00:00:00

abstract：:Endothelins regulate cellular functions in the mammalian brain through the endothelin receptors A and B (EDNRA and EDNRB). In this study, we investigated the role of EDNRB on cell proliferation in the cerebellum by using the spotting lethal (sl) rat, which carries a naturally occurring deletion in the EDNRB gene. Prol...

journal_title：Cellular and molecular neurobiology

authors： Vidovic M,Chen MM,Lu QY,Kalloniatis KF,Martin BM,Tan AH,Lynch C,Croaker GD,Cass DT,Song ZM

更新日期：2008-12-01 00:00:00

abstract：:Green fluorescent protein (GFP) gene was transfected and expressed in murine embryonic stem (ES) cells under the control of the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter. Stably transfected cells were characterized by immunohistochemistry and by fluorescence microscopy. Cells containing GFP we...

journal_title：Cellular and molecular neurobiology

authors： Tang F,Shang K,Wang X,Gu J

更新日期：2002-02-01 00:00:00

abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

journal_title：Cellular and molecular neurobiology

authors： Takadera T,Ohyashiki T

更新日期：2007-09-01 00:00:00

abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...

journal_title：Cellular and molecular neurobiology

authors： Saunders NR,Knott GW,Dziegielewska KM

更新日期：2000-02-01 00:00:00

abstract：:1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity. 2....

journal_title：Cellular and molecular neurobiology

authors： Guevara BH,Cespedes GC,Cubeddu LX

更新日期：2002-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

更新日期：2014-04-01 00:00:00

abstract：:D-serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N-methyl-D-aspartate receptors (NMDARs). D-serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In this study, we examined the localization of D-serine and SR in the mouse striatum and the effects of genetica...

journal_title：Cellular and molecular neurobiology

authors： Takagi S,Puhl MD,Anderson T,Balu DT,Coyle JT

更新日期：2020-05-22 00:00:00

abstract：:We demonstrated synchronous oscillation of intracellular Ca2+ in cultured-mouse mid-brain neurons. This synchronous oscillation was thought to result from spontaneous and synchronous neural bursts in a synaptic neural network. We also examined the role of endogenous dopamine in neural networks showing synchronous osci...

journal_title：Cellular and molecular neurobiology

authors： Yasumoto F,Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

更新日期：2004-02-01 00:00:00

abstract：:To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

journal_title：Cellular and molecular neurobiology

authors： Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

更新日期：2020-10-01 00:00:00

abstract：:1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neu...

journal_title：Cellular and molecular neurobiology

authors： Hughes TK,Cadet P,Rady PL,Tyring SK,Chin R,Smith EM

更新日期：1994-02-01 00:00:00

abstract：:Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms underlying the increased iron are still unknown. Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1)...

journal_title：Cellular and molecular neurobiology

authors： Wang J,Bi M,Xie J

更新日期：2015-07-01 00:00:00

abstract：:Naked2 (NKD2), one member of Naked family, has been shown to negatively regulate Wnt/β-catenin signaling pathway. It has been recognized that NKD2 plays a vital role in cell homeostasis and prevention of tumorigenesis. However, NKD2 expression and its functional role in the brain in neuroinflammatory processes remain ...

journal_title：Cellular and molecular neurobiology

authors： Cui Z,Zhou L,Song Y,Liu C,Zhu G,Wu X,Yan Y,Xia X,Duan C,Zhou Y,Huang Y,Zhang D

更新日期：2016-01-01 00:00:00

abstract：:1. The central nervous systems (CNS) of males and females differ in the control mechanisms for the release of gonadotropins from the anterior pituitary gland as well as the capacity to display sex specific behaviors. 2. In guinea pigs and monkeys, these differences are organized through the actions of prenatal androge...

journal_title：Cellular and molecular neurobiology

authors： Resko JA,Roselli CE

更新日期：1997-12-01 00:00:00

abstract：:Spinal cord injury (SCI) remains a formidable challenge in the clinic. In the current study, we examined the effects of the TLX gene on the proliferation and neuronal differentiation of dermal multipotent stem cells (DMSCs) in vitro and the potential of these cells to improve SCI in rats in vivo. DMSCs were stably tra...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Ren X,Xiong J,Zhang L,Qu J,Xu W

更新日期：2011-04-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs which mediate post-transcriptional gene regulation. Recently, microRNAs have also been found to be localized to the extracellular space, often encapsulated in secreted extracellular vesicles (EVs). This tandem of EVs and tissue-specific expressed/secreted microRNAs that can be taken...

journal_title：Cellular and molecular neurobiology

authors： Bronisz A,Godlewski J,Chiocca EA

更新日期：2016-04-01 00:00:00

abstract：:1. We have used horseradish peroxidase-conjugated protein A- and 125I-protein A to develop immunohistochemical and radioimmunohistochemical methods for the localization of antigens in brain and other tissues of the rat. 2. We visualized methionine-enkephalin fibers in the rat brain by incubating tissue sections with a...

journal_title：Cellular and molecular neurobiology

authors： Correa FM,Guilhaume SS,Saavedra JM

更新日期：1988-03-01 00:00:00

abstract：:We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...

journal_title：Cellular and molecular neurobiology

authors： Osborn O,Sanchez-Alavez M,Brownell SE,Ross B,Klaus J,Dubins J,Beutler B,Conti B,Bartfai T

更新日期：2010-01-01 00:00:00

abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...

journal_title：Cellular and molecular neurobiology

authors： Laitinen JT,Laitinen KS,Kokkola T

更新日期：1995-04-01 00:00:00

abstract：:1. Wobbler mice suffer an autosomal recessive mutation producing severe motoneuron degeneration and dense astrogliosis, with increased levels of glial fibrillary acidic protein (GFAP) in the spinal cord and brain stem. They have been considered animal models of amyotrophic lateral sclerosis and infantile spinal muscul...

journal_title：Cellular and molecular neurobiology

authors： Gonzalez Deniselle MC,Gonzalez SL,Piroli GG,Lima AE,De Nicola AF

更新日期：1996-02-01 00:00:00

abstract：:Oxidative stress is one of the mechanisms implicated to play a significant role in the pathophysiology of Parkinson's disease. Previously, we showed that an aqueous extract of Selaginella delicatula (SDAE) offered robust neuroprotection against rotenone (ROT) in a Drosophila model. In furtherance in the present study,...

journal_title：Cellular and molecular neurobiology

authors： Chandran G,Muralidhara

更新日期：2013-10-01 00:00:00

abstract：:microRNAs (miRNAs) comprise a class of ~18-25 nucleotide (nt) single-stranded non-coding RNAs (sncRNAs) that are the smallest known carriers of gene-encoded, post-transcriptional regulatory information in both plants and animals. There are many fundamental similarities between plant and animal miRNAs-the miRNAs of bot...

journal_title：Cellular and molecular neurobiology

authors： Zhao Y,Cong L,Lukiw WJ

更新日期：2018-01-01 00:00:00

abstract：:Hypoxia in neonates can lead to biochemical and molecular alterations mediated through changes in neurotransmitters resulting in permanent damage to brain. In this study, we evaluated the changes in the receptor status of GABA(A) in the cerebral cortex and brainstem of hypoxic neonatal rats and hypoxic rats supplement...

journal_title：Cellular and molecular neurobiology

authors： Anju TR,Peeyush Kumar T,Paulose CS

更新日期：2010-05-01 00:00:00

abstract：:In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the...

journal_title：Cellular and molecular neurobiology

authors： Yan BC,Park JH,Kim SK,Choi JH,Lee CH,Yoo KY,Kwon YG,Kim YM,Kim JD,Won MH

更新日期：2012-11-01 00:00:00

abstract：:(1) Axons contain numerous mRNAs and a local protein synthetic system that can be regulated independently of the cell body. (2) In this study, cultured primary sympathetic neurons were employed, to assess the effect of local protein synthesis blockade on axon viability and mitochondrial function. (3) Inhibition of loc...

journal_title：Cellular and molecular neurobiology

authors： Hillefors M,Gioio AE,Mameza MG,Kaplan BB

更新日期：2007-09-01 00:00:00

abstract：:1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field te...

journal_title：Cellular and molecular neurobiology

authors： Gil MC,Aguirre JA,Lemoine AP,Segura ET,Barontini M,Armando I

更新日期：1999-10-01 00:00:00

abstract：:Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypert...

journal_title：Cellular and molecular neurobiology

authors： Chen Y,Rao F,Wen G,Gayen JR,Zhang K,Vaingankar SM,Biswas N,Mahata M,Friese RS,Fung MM,Salem RM,Nievergelt C,Bhatnagar V,Hook VY,Ziegler MG,Mahata SK,Hamilton BA,O'Connor DT

更新日期：2010-11-01 00:00:00

abstract：:Available treatment for Parkinson's disease (PD) is mainly symptomatic instead of halting or reversing degenerative processes affecting the disease. Research on the molecular pathogenesis of PD has suggested reduced trophic support as a possible cause or mediator of neurodegeneration. In animal models of the disease, ...

journal_title：Cellular and molecular neurobiology

authors： Gyárfás T,Knuuttila J,Lindholm P,Rantamäki T,Castrén E

更新日期：2010-04-01 00:00:00