The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.

abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...

journal_title：Cellular and molecular neurobiology

authors： Saunders NR,Knott GW,Dziegielewska KM

更新日期：2000-02-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:Dideoxycytidine (zalcitabine, ddC) produces neurotoxic effects. It is particularly important to understand the toxic effects of ddC on different subpopulations of dorsal root ganglion (DRG) neurons which express distinct tyrosine kinase receptor (Trk) and to find therapeutic factors for prevention and therapy for ddC-...

journal_title：Cellular and molecular neurobiology

authors： Liu H,Lu J,He Y,Yuan B,Li Y,Li X

更新日期：2014-03-01 00:00:00

abstract：:1. The original concept of the ischemic penumbra surrounding a focus of dense cerebral ischemia is based on electrophysiological observations. In the cortex of baboons following middle cerebral artery occlusion, complete failure of the cortical evoked potential was observed at a cerebral blood flow (CBF) threshold lev...

journal_title：Cellular and molecular neurobiology

authors： Back T

更新日期：1998-12-01 00:00:00

abstract：:Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction lead...

journal_title：Cellular and molecular neurobiology

authors： Sajjad N,Wani A,Sharma A,Ali R,Hassan S,Hamid R,Habib H,Ganai BA

更新日期：2019-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a devastating motoneuron disorder for which no effective treatment exists. There is some evidence for neuroprotective effects of valproic acid (VPA). The beneficial effects, however, are limited due to the adverse effects of VPA. To overcome this problem, a number of VPA derivates with...

journal_title：Cellular and molecular neurobiology

authors： Ragancokova D,Song Y,Nau H,Dengler R,Krampfl K,Petri S

更新日期：2010-08-01 00:00:00

abstract：:1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...

journal_title：Cellular and molecular neurobiology

authors： Ivanova JL,Leonova OG,Popenko VI,Ierusalimsky VN,Korshunova TA,Boguslavsky DV,Malyshev AY,Balaban PM,Belyavsky AV

更新日期：2006-03-01 00:00:00

abstract：:1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second mess...

journal_title：Cellular and molecular neurobiology

authors： Winkler H,Fischer-Colbrie R

更新日期：1998-04-01 00:00:00

abstract：:The effects of the calcium channel blocker D-600 on the cation channels activated by acetylcholine (ACh) was studied in voltage-clamped Aplysia neurons by voltage-jump relaxation analysis. D-600 blocked the steady-state ACh current in a highly voltage-dependent manner, the degree of antagonism increasing with membrane...

journal_title：Cellular and molecular neurobiology

authors： Slater NT,Haas HL,Carpenter DO

更新日期：1983-12-01 00:00:00

abstract：:Acute encephalopathy is a generic term for acute brain dysfunction occurring after infection. Acute encephalopathy induced by influenza virus results in high mortality, and most cases of influenza-associated encephalopathy (IAE) result in brain edema. Administration of diclofenac sodium (DCF), a non-steroidal anti-inf...

journal_title：Cellular and molecular neurobiology

authors： Asai H,Kakita H,Aoyama M,Nagaya Y,Saitoh S,Asai K

更新日期：2013-04-01 00:00:00

abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

journal_title：Cellular and molecular neurobiology

authors： Pozdnyakova N,Dudarenko M,Borisova T

更新日期：2019-07-01 00:00:00

abstract：:Ac2-26, a mimetic peptide of Annexin-A1, plays a vital role in the anti-inflammatory response mediated by astrocytes. In this study, we aimed to explore the underlying mechanisms of Ac2-26-mediated anti-inflammatory effect. Specifically, we investigated the inhibitory effects of Ac2-26 on lipopolysaccharide (LPS)-indu...

journal_title：Cellular and molecular neurobiology

authors： Luo Z,Wang H,Fang S,Li L,Li X,Shi J,Zhu M,Tan Z,Lu Z

更新日期：2020-05-01 00:00:00

abstract：:Pulsed radiofrequency (PRF) treatment involves the pulsed application of a radiofrequency electric field to a nerve. The technology offers pain relief for patients suffering from chronic pain who do not respond well to conventional treatments. We tested whether PRF treatment attenuated complete Freund's adjuvant (CFA)...

journal_title：Cellular and molecular neurobiology

authors： Chen KH,Yang CH,Juang SE,Huang HW,Cheng JK,Sheen-Chen SM,Cheng JT,Lin CR

更新日期：2014-03-01 00:00:00

abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

journal_title：Cellular and molecular neurobiology

authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

更新日期：2010-01-01 00:00:00

abstract：:Spaceflight and simulated microgravity both affect learning and memory, which are mostly controlled by the hippocampus. However, data about molecular alterations in the hippocampus in real or simulated microgravity conditions are limited. Adult Wistar rats were recruited in the experiments. Here we analyzed whether sh...

journal_title：Cellular and molecular neurobiology

authors： Berezovskaya AS,Tyganov SA,Nikolaeva SD,Naumova AA,Merkulyeva NS,Shenkman BS,Glazova MV

更新日期：2020-07-18 00:00:00

abstract：:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate ...

journal_title：Cellular and molecular neurobiology

authors： Vilá-Ortiz GJ,Santa-Coloma TA,Carminatti H,Radrizzani M

更新日期：2001-10-01 00:00:00

abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

journal_title：Cellular and molecular neurobiology

authors： Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

更新日期：2015-11-01 00:00:00

abstract：AIMS:Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels...

journal_title：Cellular and molecular neurobiology

authors： Ulus IH,Watkins CJ,Cansev M,Wurtman RJ

更新日期：2006-07-01 00:00:00

abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...

journal_title：Cellular and molecular neurobiology

authors： Foley TD,Clark AR,Stredny ES,Wierbowski BM

更新日期：2012-03-01 00:00:00

abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

journal_title：Cellular and molecular neurobiology

authors： Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

更新日期：2012-01-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are considered a promising tool for cell-based therapies of nervous system diseases. Bone marrow (BM) has been the traditional source of MSCs (BM-MSCs). However, there are some limitations for their clinical use, such as the decline in cell number and differentiation potential with ...

journal_title：Cellular and molecular neurobiology

authors： Yan ZJ,Hu YQ,Zhang HT,Zhang P,Xiao ZY,Sun XL,Cai YQ,Hu CC,Xu RX

更新日期：2013-05-01 00:00:00

abstract：:1. Doubly transgenic mice were some differences in the period proceeding of the development of Abeta-42 deposits and behavioral deficits. It was not characterized human mutant PS2 (hPS2) with APPsw in the brains of double transgenic mice. The aim of this study was to examine whether doubly transgenic mice co-expressin...

journal_title：Cellular and molecular neurobiology

authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Song CW,Lee SH,Kim YK

更新日期：2005-08-01 00:00:00

abstract：:1. Five drugs with the predominant pharmacologic effect of inhibiting the neuronal reuptake of serotonin are available worldwide for clinical use. This class of psychoactive drugs, known as selective serotonin reuptake inhibitors (SSRIs), is comprised of fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram....

journal_title：Cellular and molecular neurobiology

authors： DeVane CL

更新日期：1999-08-01 00:00:00

abstract：:1. Data obtained studying permeability characteristics of single Deiters' membranes in a microchamber system show that intracellular GABA can activate chloride in-->out passage with a GABAA pharmacology. 2. The overall data suggest the presence of a chloride extrusion pump in these neurons based on intracellular GABA ...

journal_title：Cellular and molecular neurobiology

authors： Rapallino MV,Cupello A,Hydén H

更新日期：1999-12-01 00:00:00

abstract：:MEG8 is involved in ischemia stroke, however, its role in ischemia stroke remains unknown. The current research aimed to investigate the effects and mechanisms of MEG8 in ischemic stroke. Mouse brain microvascular endothelial cells (BMECs) were treated by oxygen-glucose deprivation (OGD). Then, the expressions of MEG8...

journal_title：Cellular and molecular neurobiology

authors： Sui S,Sun L,Zhang W,Li J,Han J,Zheng J,Xin H

更新日期：2020-07-05 00:00:00

abstract：:(1) Axons contain numerous mRNAs and a local protein synthetic system that can be regulated independently of the cell body. (2) In this study, cultured primary sympathetic neurons were employed, to assess the effect of local protein synthesis blockade on axon viability and mitochondrial function. (3) Inhibition of loc...

journal_title：Cellular and molecular neurobiology

authors： Hillefors M,Gioio AE,Mameza MG,Kaplan BB

更新日期：2007-09-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on H(2)O(2)-induced apoptosis in PC12 cells and the possible signal...

journal_title：Cellular and molecular neurobiology

authors： Gao Y,Dong C,Yin J,Shen J,Tian J,Li C

更新日期：2012-05-01 00:00:00

abstract：:MicroRNAs are small post-transcriptional regulators that modulate gene expression by directly interacting with their target transcripts. Since the interaction between miRNAs and target mRNAs does not require a perfect match, one single miRNA can influence the expression of several genes and lead to a very broad array ...

journal_title：Cellular and molecular neurobiology

authors： Marangon D,Abbracchio MP,Lecca D

更新日期：2021-01-01 00:00:00

abstract：:Inhibitory mechanism of cerebellum epileptic activity can be involved depending on the intensity and frequency of seizure convulsions. N-methyl-D-aspartate receptors (NMDARs) play key roles in excitatory synaptic transmission and have been implicated in neurological disorders: in cerebellum, they have specific charact...

journal_title：Cellular and molecular neurobiology

authors： Girardi E,Auzmendi J,Charó N,Gori MB,Castro M

更新日期：2010-10-01 00:00:00