Evidence for the production and action of interleukin-10 in pituitary cells.

abstract：:EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease. Howev...

journal_title：Cellular and molecular neurobiology

authors： Ni H,Shen J,Song Y,Cao M,Liu X,Huang J,Zhang W,Xie L,Ning X,Ke K

更新日期：2016-08-01 00:00:00

abstract：:Mental retardation, which occurs in phenylketonuric patients, is associated with increased levels of phenylalanine, increased oxidative stress, and an imbalance of amino acids in the brain. Recent studies have shown that oxidative stress plays a role in the pathogenesis of phenylketonuria. In this work, we aimed to co...

journal_title：Cellular and molecular neurobiology

authors： Kumru B,Kaplan DS,Oztürk Hismi B,Celik H

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study. METHODS:First, the proteins of CSF from MS patients and control group were analyzed individually with 2D-DIGE...

journal_title：Cellular and molecular neurobiology

authors： Qin Z,Qin Y,Liu S

更新日期：2009-03-01 00:00:00

abstract：:Acute encephalopathy is a generic term for acute brain dysfunction occurring after infection. Acute encephalopathy induced by influenza virus results in high mortality, and most cases of influenza-associated encephalopathy (IAE) result in brain edema. Administration of diclofenac sodium (DCF), a non-steroidal anti-inf...

journal_title：Cellular and molecular neurobiology

authors： Asai H,Kakita H,Aoyama M,Nagaya Y,Saitoh S,Asai K

更新日期：2013-04-01 00:00:00

abstract：:1. The cytochrome P450 enzyme family is one of the major drug metabolizing systems in man. 2. Factors such as age, gender, race, environment, and drug treatment may have considerable influence on the activity of these enzymes. 3. There are now well-established in vitro techniques for assessing the role of specific cyt...

journal_title：Cellular and molecular neurobiology

authors： Glue P,Clement RP

更新日期：1999-06-01 00:00:00

abstract：:An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent pas...

journal_title：Cellular and molecular neurobiology

authors： Tiwari RK,Singh S,Gupta CL,Bajpai P

更新日期：2020-07-20 00:00:00

abstract：:In chromaffin cells, SNARE proteins, forming the basic exocytotic machinery are present in membrane clusters of 500-600 nm in diameter. These microdomains containing both SNAP-25 and syntaxin-1 are dynamic and the expression of altered forms of SNAREs modifies not only their motion but also the mobility of the associa...

journal_title：Cellular and molecular neurobiology

authors： Torregrosa-Hetland CJ,Villanueva J,López-Font I,Garcia-Martinez V,Gil A,Gonzalez-Vélez V,Segura J,Viniegra S,Gutiérrez LM

更新日期：2010-11-01 00:00:00

abstract：:1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

journal_title：Cellular and molecular neurobiology

authors： Schorderet M,Nowak JZ

更新日期：1990-09-01 00:00:00

abstract：:Symptoms like mental retardation, depression, and anxiety have been observed during aging. Almost similar phenotypes have been evident in patients having haploinsufficiency or mutations in Pax6, a transcriptional regulator. Since Pax6 regulates axon guidance, differentiation of neurons from glia, and neuronal migratio...

journal_title：Cellular and molecular neurobiology

authors： Tripathi R,Mishra R

更新日期：2012-03-01 00:00:00

abstract：:1. Accumulation of different c-erbA transcripts was studied, during rat brain maturation and in cortical neurons differentiating in a serum-free medium, by quantitative Northern blot hybridization. 2. The alpha and beta forms of c-erbA mRNAs exhibit different patterns of accumulation, with a precocious increase in the...

journal_title：Cellular and molecular neurobiology

authors： Castiglia D,Cestelli A,Di Liegro C,Bonfanti L,Di Liegro I

更新日期：1992-06-01 00:00:00

abstract：:1. The role of oxidative stress, and accordingly uncontrolled reactive oxygen species generation/action, have been widely documented in a number of different neuronal pathologies. However, the concept of pharmacological interventions in prevention and therapy of oxidative stress-related diseases has not found adequate...

journal_title：Cellular and molecular neurobiology

authors： Stolc S,Snirc V,Májeková M,Gáspárová Z,Gajdosíková A,Stvrtina S

更新日期：2006-10-01 00:00:00

abstract：:1. The analogies between the processing of amyloid precursor protein (APP) and other transmembrane sterol regulatory element binding proteins (SREBPs) inspired us to conduct further studies on whether beta-amyloid (Abeta) affects aromatase by interacting with APP and SREBP. 2. In this study, cultured human neuroblasto...

journal_title：Cellular and molecular neurobiology

authors： Kelicen P,Nordberg A

更新日期：2006-05-01 00:00:00

abstract：:1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine...

journal_title：Cellular and molecular neurobiology

authors： Stefano GB,Sawada M,Smith EM,Hughes TK

更新日期：1993-12-01 00:00:00

abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

journal_title：Cellular and molecular neurobiology

authors： Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

更新日期：1998-06-01 00:00:00

abstract：:1. Angiotensin II receptors have been studied by quantitative autoradiography in selected brain areas of young (2-week-old) and adult (8-week-old) rats. 2. In young rats, angiotensin II receptors were present in brain areas which did not express receptors in the adult brain, such as thalamic nuclei, cortical areas, an...

journal_title：Cellular and molecular neurobiology

authors： Tsutsumi K,Saavedra JM

更新日期：1991-04-01 00:00:00

abstract：:1. Gamma-aminobutryic acid (GABA), a major inhibitory transmitter of the vertebrate retina, is synthesized from glutamate by L-glutamate decarboxylase (GAD) and mediates neuronal inhibition at GABAA receptors. GAD consists of two distinct molecular forms, GAD65 and GAD67, which have similar distribution patterns in th...

journal_title：Cellular and molecular neurobiology

authors： Brecha NC,Sternini C,Humphrey MF

更新日期：1991-10-01 00:00:00

abstract：:Ac2-26, a mimetic peptide of Annexin-A1, plays a vital role in the anti-inflammatory response mediated by astrocytes. In this study, we aimed to explore the underlying mechanisms of Ac2-26-mediated anti-inflammatory effect. Specifically, we investigated the inhibitory effects of Ac2-26 on lipopolysaccharide (LPS)-indu...

journal_title：Cellular and molecular neurobiology

authors： Luo Z,Wang H,Fang S,Li L,Li X,Shi J,Zhu M,Tan Z,Lu Z

更新日期：2020-05-01 00:00:00

abstract：:1. Gonadotropin-releasing hormone (GnRH) was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, during evolution the peptide was subject to gene duplication and structural changes, and multiple m...

journal_title：Cellular and molecular neurobiology

authors： King JA,Millar RP

更新日期：1995-02-01 00:00:00

abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

journal_title：Cellular and molecular neurobiology

authors： Rutigliano G,Zucchi R

更新日期：2020-03-01 00:00:00

abstract：:1. The central nervous systems (CNS) of males and females differ in the control mechanisms for the release of gonadotropins from the anterior pituitary gland as well as the capacity to display sex specific behaviors. 2. In guinea pigs and monkeys, these differences are organized through the actions of prenatal androge...

journal_title：Cellular and molecular neurobiology

authors： Resko JA,Roselli CE

更新日期：1997-12-01 00:00:00

abstract：:Normokalemic periodic paralysis (normoPP) is a type of skeletal muscle function disorder which is characterized by paralysis attack with concomitant normal serum potassium level. We previously reported that R675Q mutation of human skeletal muscle voltage-gated sodium channel α subunit (SCN4A) may be the novel mutation...

journal_title：Cellular and molecular neurobiology

authors： Wu L,Zhang B,Kang Y,Wu W

更新日期：2014-07-01 00:00:00

abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

journal_title：Cellular and molecular neurobiology

authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

更新日期：1998-08-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant r...

journal_title：Cellular and molecular neurobiology

authors： Chen C,Hu Y,Dong XZ,Zhou XJ,Mu LH,Liu P

更新日期：2018-07-01 00:00:00

abstract：:1. The possibility that a long-lasting neuronal activation regulates the expression of muscarinic cholinergic receptors was studied with three cultured neuronal cell lines. 2. Continuous depolarization of a subclone of the neuroblastoma-glioma NG108-15 hybrid cells with potassium chloride increased by 45-75% the numbe...

journal_title：Cellular and molecular neurobiology

authors： Simantov R,Levy R

更新日期：1989-03-01 00:00:00

abstract：:Oxidative glutamate toxicity plays a vital role in the neurodegeneration diseases, including Alzheimer's diseases (AD). This study set out with the aim to investigate the beneficial effects of fangchinoline (FAN), a natural alkaloid, against glutamate-induced oxidative damage, and to clarify the underlying cellular an...

journal_title：Cellular and molecular neurobiology

authors： Bao F,Tao L,Zhang H

更新日期：2019-11-01 00:00:00

abstract：:Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

journal_title：Cellular and molecular neurobiology

authors： Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

更新日期：2017-03-01 00:00:00

abstract：:1. Transient forebrain ischemia in adult rats, induced by 10 min of bilateral carotid occlusion and an arterial hypotension of 40 mmHg, caused substantial damage not only to CA-1 neurons in hippocampus but also to epithelial cells in lateral ventricle choroid plexus. 2. When transient forebrain ischemia was followed b...

journal_title：Cellular and molecular neurobiology

authors： Johanson CE,Palm DE,Primiano MJ,McMillan PN,Chan P,Knuckey NW,Stopa EG

更新日期：2000-04-01 00:00:00

abstract：:Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

journal_title：Cellular and molecular neurobiology

authors： Semm P,Demaine C,Vollrath L

更新日期：1981-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

更新日期：2014-04-01 00:00:00

abstract：:Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated...

journal_title：Cellular and molecular neurobiology

authors： Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

更新日期：2005-12-01 00:00:00