Abstract:
:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML) of the spinal cord, the midbrain periaqueductal gray (PAG), and the brainstem locus coeruleus (LC). 2. A combination of retrograde fluorescent neuronal tracing and immunocytochemical identification revealed MCH neurons that project to IML, PAG, and LC. Subsequent to isolation of these single neurons by laser microdissection, multi-transcriptional profiling by means of real-time RT-PCR demonstrated different expression patterns between sympathetically projecting MCH neurons and those targeting the PAG or LC. 3. These results provide evidence for the existence of projection-dependent MCH neuronal subpopulations with functional differentiation in the context of controlling energy homeostasis, autonomic functioning, and arousal.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Harthoorn LFdoi
10.1007/s10571-006-9115-zsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
49-55issue
1eissn
0272-4340issn
1573-6830journal_volume
27pub_type
杂志文章abstract::Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...
journal_title:Cellular and molecular neurobiology
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doi:10.1007/s10571-011-9739-5
更新日期:2012-01-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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更新日期:1983-06-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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journal_title:Cellular and molecular neurobiology
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF00711177
更新日期:1990-09-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:2016-08-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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更新日期:2017-01-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 已发布勘误
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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