Projection-dependent differentiation of melanin-concentrating hormone-containing neurons.

Abstract:

:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML) of the spinal cord, the midbrain periaqueductal gray (PAG), and the brainstem locus coeruleus (LC). 2. A combination of retrograde fluorescent neuronal tracing and immunocytochemical identification revealed MCH neurons that project to IML, PAG, and LC. Subsequent to isolation of these single neurons by laser microdissection, multi-transcriptional profiling by means of real-time RT-PCR demonstrated different expression patterns between sympathetically projecting MCH neurons and those targeting the PAG or LC. 3. These results provide evidence for the existence of projection-dependent MCH neuronal subpopulations with functional differentiation in the context of controlling energy homeostasis, autonomic functioning, and arousal.

journal_name

Cell Mol Neurobiol

authors

Harthoorn LF

doi

10.1007/s10571-006-9115-z

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

49-55

issue

1

eissn

0272-4340

issn

1573-6830

journal_volume

27

pub_type

杂志文章
  • Nitric oxide potentiates TNF-α-induced neurotoxicity through suppression of NF-κB.

    abstract::Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-011-9739-5

    authors: Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

    更新日期:2012-01-01 00:00:00

  • Sodium-independent taurine binding to brain synaptic membranes.

    abstract::Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceabl...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00735281

    authors: Kontro P,Oja SS

    更新日期:1983-06-01 00:00:00

  • Long-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine.

    abstract::1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-005-3974-6

    authors: Chepkova AN,Sergeeva OA,Haas HL

    更新日期:2005-06-01 00:00:00

  • What can we know from pituitary-adrenal hormones about the nature and consequences of exposure to emotional stressors?

    abstract::Exposure to stress induces profound physiological and behavioral changes in the organisms and some of these changes may be important regarding stress-induced pathologies and animal models of psychiatric diseases. Consequences of stress are dependent on the duration of exposure to stressors (acute, chronic), but also o...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-012-9814-6

    authors: Armario A,Daviu N,Muñoz-Abellán C,Rabasa C,Fuentes S,Belda X,Gagliano H,Nadal R

    更新日期:2012-07-01 00:00:00

  • Evidence for site selection during synaptogenesis: the surface distribution of synaptic sites in photoreceptor terminals of the files Musca and Drosophila.

    abstract::1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF02151904

    authors: Meinertzhagen IA,Hu X

    更新日期:1996-12-01 00:00:00

  • Morphological characteristics of different types of neurons in the ventrooralis anterior, ventrooralis internus, and ventrooralis posterior nuclei in the human thalamus.

    abstract::1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00712927

    authors: al-Hussain SM

    更新日期:1992-06-01 00:00:00

  • Signals involved in targeting membrane proteins to synaptic vesicles.

    abstract::1. Synaptic vesicles (SVs) mediate fast regulated secretion of classical neurotransmitters. In order to perform their task SVs rely on a restrict set of membrane proteins. The mechanisms responsible for targeting these proteins to the SV membrane are still poorly understood. 2. Likewise, little is known about the intr...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1021884319363

    authors: Prado VF,Prado MA

    更新日期:2002-12-01 00:00:00

  • Social Behaviour and Epigenetic Status in Adolescent and Adult Rats: The Contribution of Early-Life Stressful Social Experience.

    abstract::Early-life experiences have been linked to individual's epigenetic status and social behaviour. Therefore, the present study aims to test whether the presence of mother suppress the early-life stressful social experience (SSE)-induced effect on social behaviour of adolescent and adult rats, and associated epigenetic c...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-019-00655-x

    authors: Karen C,Rajan KE

    更新日期:2019-04-01 00:00:00

  • Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment in Acute Ischemic Stroke.

    abstract::Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-020-00985-1

    authors: Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

    更新日期:2020-10-30 00:00:00

  • Metabolic characterization of a mouse deficient in all known leptin receptor isoforms.

    abstract::We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9427-x

    authors: Osborn O,Sanchez-Alavez M,Brownell SE,Ross B,Klaus J,Dubins J,Beutler B,Conti B,Bartfai T

    更新日期:2010-01-01 00:00:00

  • Expression of platelet-derived growth factor (PDGF) receptor alpha-subunit in mouse brain: comparison of Patch mutants and normal littermates.

    abstract::1. Platelet-derived growth factor (PDGF) plays an important role not only in mesenchyme-derived tissues, but also in the mammalian central nervous system. The Patch mutant (Ph/+) lacks one copy of the PDGFR-alpha gene. However, it is not clear whether there are differences in expression of PDGF receptor alpha-subunit ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF02150228

    authors: Zhang FX,Hutchins JB

    更新日期:1996-08-01 00:00:00

  • Retinal dopamine D1 and D2 receptors: characterization by binding or pharmacological studies and physiological functions.

    abstract::1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00711177

    authors: Schorderet M,Nowak JZ

    更新日期:1990-09-01 00:00:00

  • Nanosecond electric pulses: a novel stimulus for triggering Ca2+ influx into chromaffin cells via voltage-gated Ca2+ channels.

    abstract::Exposing bovine chromaffin cells to a single 5 ns, high-voltage (5 MV/m) electric pulse stimulates Ca(2+) entry into the cells via L-type voltage-gated Ca(2+) channels (VGCC), resulting in the release of catecholamine. In this study, fluorescence imaging was used to monitor nanosecond pulse-induced effects on intracel...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9573-1

    authors: Craviso GL,Choe S,Chatterjee P,Chatterjee I,Vernier PT

    更新日期:2010-11-01 00:00:00

  • EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.

    abstract::EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease. Howev...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-015-0287-2

    authors: Ni H,Shen J,Song Y,Cao M,Liu X,Huang J,Zhang W,Xie L,Ning X,Ke K

    更新日期:2016-08-01 00:00:00

  • Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.

    abstract::Although Butylphthalide (BP) has protective effects that reduce ischemia-induced brain damage and neuronal cell death, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of BP against isch...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-015-0302-7

    authors: Wen XR,Tang M,Qi DS,Huang XJ,Liu HZ,Zhang F,Wu J,Wang YW,Zhang XB,Guo JQ,Wang SL,Liu Y,Wang YL,Song YJ

    更新日期:2016-10-01 00:00:00

  • Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat Light-Induced Retina Damage Model.

    abstract::Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0346-3

    authors: Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

    更新日期:2017-01-01 00:00:00

  • Axon viability and mitochondrial function are dependent on local protein synthesis in sympathetic neurons.

    abstract::(1) Axons contain numerous mRNAs and a local protein synthetic system that can be regulated independently of the cell body. (2) In this study, cultured primary sympathetic neurons were employed, to assess the effect of local protein synthesis blockade on axon viability and mitochondrial function. (3) Inhibition of loc...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-007-9148-y

    authors: Hillefors M,Gioio AE,Mameza MG,Kaplan BB

    更新日期:2007-09-01 00:00:00

  • An electrogenic ionic pump derived from an ionotropic receptor: assessment of a candidate.

    abstract::1. Data obtained studying permeability characteristics of single Deiters' membranes in a microchamber system show that intracellular GABA can activate chloride in-->out passage with a GABAA pharmacology. 2. The overall data suggest the presence of a chloride extrusion pump in these neurons based on intracellular GABA ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1006944820946

    authors: Rapallino MV,Cupello A,Hydén H

    更新日期:1999-12-01 00:00:00

  • Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.

    abstract::Somatostatin which is a multifunctional growth hormone inhibitory neuropeptide shows diverse physiological effects, such as neurotransmission, cell growth, apoptosis, and endocrine signaling as well as exerts inhibitory effects on hormonal products and other secretory proteins. SSTR3 is a member of superfamily of soma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-017-0471-7

    authors: Yao Q,Liu Q,Xu H,Wu Z,Zhou L,Gu Z,Gong P,Shen J

    更新日期:2017-11-01 00:00:00

  • Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0377-9

    authors: Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

    更新日期:2017-04-01 00:00:00

  • Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.

    abstract::1. The aims of the present study were (a) to determine the identity of the G proteins with which the endothelin receptor interacts and whether this interaction is subtype specific and (b) to determine whether agonist exposure can result in specific coupling between the endothelin receptor and G proteins. 2. Coupling b...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1007010125316

    authors: Shraga-Levine Z,Sokolovsky M

    更新日期:2000-06-01 00:00:00

  • Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage.

    abstract::The hematopoietic cell kinase (Hck) is a member of the Src family protein kinases which regulates many signal transduction pathways including cell growth, proliferation, differentiation, migration, and apoptosis. However, the expression and function of Hck after intracerebral hemorrhage (ICH) are unknown. Western blot...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-016-0365-0

    authors: Wang J,Chen R,Liu X,Shen J,Yan Y,Gao Y,Tao T,Shi J

    更新日期:2017-03-01 00:00:00

  • Cell proliferation in the adult rat rostral migratory stream following exposure to gamma irradiation.

    abstract::One of the few areas of the adult CNS, that are known to be competent for neuronal proliferation, is the subventricular zone (SVZ) lining the brain lateral ventricles. Cells proliferating in the SVZ migrate along a defined pathway, the rostral migratory stream (RMS), where their proliferation continues until reaching ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-006-9067-3

    authors: Bálentová S,Raceková E,Martoncíková M,Misúrová E

    更新日期:2006-10-01 00:00:00

  • The E646D-ATP13A4 mutation associated with autism reveals a defect in calcium regulation.

    abstract::ATP13A4 is a member of the subfamily of P5-type ATPases. P5-type ATPases are the least studied of the P-type ATPase subfamilies with no ion specificities assigned to them. In order to elucidate ATP13A4 function, we studied the protein's subcellular localization and tested whether it is involved in calcium regulation. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9445-8

    authors: Vallipuram J,Grenville J,Crawford DA

    更新日期:2010-03-01 00:00:00

  • Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.

    abstract::1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/b:cemn.0000005321.11544.cc

    authors: Chiu R,Rey O,Zheng JQ,Twiss JL,Song J,Pang S,Yokoyama KK

    更新日期:2003-12-01 00:00:00

  • Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents.

    abstract::1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF02088688

    authors: Platt B,Büsselberg D

    更新日期:1994-12-01 00:00:00

  • Correction to: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1.

    abstract::The original version of this article unfortunately contained a typo in co-author name. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 已发布勘误

    doi:10.1007/s10571-020-00990-4

    authors: Narayan A,Hunkele A,Xu J,Bassoni DL,Pasternak GW,Pan YX

    更新日期:2020-10-31 00:00:00

  • Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).

    abstract::Glial cells have various important roles in regulation of brain functions. For such events, extracellular nucleotides/P2 receptors have central roles. Although there have been huge amount of literature about activation of P2 receptors and glial functions, little is known about what happens in glia or the brain if glia...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-012-9869-4

    authors: Kinoshita M,Nasu-Tada K,Fujishita K,Sato K,Koizumi S

    更新日期:2013-01-01 00:00:00

  • Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.

    abstract::The stimulation of peripheral opioid receptors counteracts thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 cells in mice, through the activation of the nitric oxide/cGMP/ATP-sensitive K+-channels (NO/cGMP/K(+) (ATP)) cascade (Menéndez et al. 2007, Neuropharmacology 53:71-80). We aimed to eluc...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9272-3

    authors: Curto-Reyes V,Juárez L,García-Pérez E,Fresno MF,Hidalgo A,Menéndez L,Baamonde A

    更新日期:2008-11-01 00:00:00

  • The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons.

    abstract::We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9288-8

    authors: Xiang H,Tao W,Wang L,Wang F,Xu A

    更新日期:2008-12-01 00:00:00