Projection-dependent differentiation of melanin-concentrating hormone-containing neurons.


:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML) of the spinal cord, the midbrain periaqueductal gray (PAG), and the brainstem locus coeruleus (LC). 2. A combination of retrograde fluorescent neuronal tracing and immunocytochemical identification revealed MCH neurons that project to IML, PAG, and LC. Subsequent to isolation of these single neurons by laser microdissection, multi-transcriptional profiling by means of real-time RT-PCR demonstrated different expression patterns between sympathetically projecting MCH neurons and those targeting the PAG or LC. 3. These results provide evidence for the existence of projection-dependent MCH neuronal subpopulations with functional differentiation in the context of controlling energy homeostasis, autonomic functioning, and arousal.


Cell Mol Neurobiol


Harthoorn LF




Has Abstract


2007-02-01 00:00:00












  • Release and effect of gamma-aminobutyric acid (GABA) on rat pineal melatonin production in vitro.

    abstract::1. 3H-gamma-Aminobutyric acid (GABA) release elicited by a depolarizing K+ stimulus or by noradrenergic transmitter was examined in rat pineals in vitro. 2. The release of 3H-GABA was detectable at a 20 mM K+ concentration in medium and increased steadily up to 80 mM K+. 3. In a Ca2+-free medium 3H-GABA release elicit...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Rosenstein RE,Chuluyan HE,Pereyra EN,Cardinali DP

    更新日期:1989-06-01 00:00:00

  • 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect.

    abstract::Inhibitory mechanism of cerebellum epileptic activity can be involved depending on the intensity and frequency of seizure convulsions. N-methyl-D-aspartate receptors (NMDARs) play key roles in excitatory synaptic transmission and have been implicated in neurological disorders: in cerebellum, they have specific charact...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Girardi E,Auzmendi J,Charó N,Gori MB,Castro M

    更新日期:2010-10-01 00:00:00

  • DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation.

    abstract::The pathogenesis of Alzheimer's disease (AD) has been strongly associated with the accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. A clinical trial in which AD patients were immunized with Aβ42 peptide was stopped when 6% of participants showed ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Lambracht-Washington D,Qu BX,Fu M,Anderson LD Jr,Stüve O,Eagar TN,Rosenberg RN

    更新日期:2011-08-01 00:00:00

  • Altered expression of the prion gene in rat astrocyte and neuron cultures treated with prion peptide 106-126.

    abstract::Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

    更新日期:2005-12-01 00:00:00

  • AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats.

    abstract::The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to reduce stress responses. Acute restraint stress (ARS) is a stress mo...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Brasil TFS,Fassini A,Corrêa FM

    更新日期:2018-01-01 00:00:00

  • Exocytosis in single chromaffin cells: regulation by a secretory granule-associated Go protein.

    abstract::1. Besides having a role in signal transduction, trimeric G proteins may also be involved in membrane trafficking events. In chromaffin cells, G alpha o has been found associated with the membrane of secretory granules. Here we examined the role of Go in regulated exocytosis using pressure microinjection combined with...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Vitale N,Gonon F,Thiersé D,Aunis D,Bader MF

    更新日期:1997-02-01 00:00:00

  • The effects of volatile anesthetics on the extracellular accumulation of [(3)H]GABA in rat brain cortical slices.

    abstract::GABA is an inhibitory neurotransmitter that appears to be associated with the action of volatile anesthetics. These anesthetics potentiate GABA-induced postsynaptic currents by synaptic GABAA receptors, although recent evidence suggests that these agents also significantly affect extrasynaptic GABA receptors. However,...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Diniz PH,Guatimosim C,Binda NS,Costa FL,Gomez MV,Gomez RS

    更新日期:2014-01-01 00:00:00

  • Morphological characteristics of different types of neurons in the ventrooralis anterior, ventrooralis internus, and ventrooralis posterior nuclei in the human thalamus.

    abstract::1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: al-Hussain SM

    更新日期:1992-06-01 00:00:00

  • Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme.

    abstract::An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent pas...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Tiwari RK,Singh S,Gupta CL,Bajpai P

    更新日期:2020-07-20 00:00:00

  • Genome-Wide Sequencing Reveals Small Nucleolar RNAs Downregulated in Cerebral Cavernous Malformations.

    abstract::Cerebral cavernous malformations (CCM) are vascular malformations associated with abnormally dilated blood vessels and leaky capillaries that often result in hemorrhages. Despite recent advances, precise understanding of the cellular and molecular mechanism leading to the pathogenesis of CCM remains elusive. Emerging ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Kar S,Bali KK,Baisantry A,Geffers R,Hartmann C,Samii A,Bertalanffy H

    更新日期:2018-10-01 00:00:00

  • Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells.

    abstract::Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

    更新日期:2019-07-01 00:00:00

  • The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System.

    abstract::The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain f...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Sun Y,Zhan L,Cheng X,Zhang L,Hu J,Gao Z

    更新日期:2017-04-01 00:00:00

  • Overexpression of alpha-synuclein down-regulates BDNF expression.

    abstract::Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of nigrostriatal dopaminergic neurons. However, the molecular pathways leading to the dopaminergic neuron degeneration have remained obscure until recently. Reports demonstrated that reduction of b...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Yuan Y,Sun J,Zhao M,Hu J,Wang X,Du G,Chen NH

    更新日期:2010-08-01 00:00:00

  • Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw.

    abstract::1. Doubly transgenic mice were some differences in the period proceeding of the development of Abeta-42 deposits and behavioral deficits. It was not characterized human mutant PS2 (hPS2) with APPsw in the brains of double transgenic mice. The aim of this study was to examine whether doubly transgenic mice co-expressin...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Song CW,Lee SH,Kim YK

    更新日期:2005-08-01 00:00:00

  • Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease.

    abstract:AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

    更新日期:2003-10-01 00:00:00

  • Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin.

    abstract::1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Vega-Hernández A,Felix R

    更新日期:2002-04-01 00:00:00

  • Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease.

    abstract::Cholesterol, a principal constituent of the cell membrane, plays a crucial role in the brain by regulating the synaptic transmission, neuronal signaling, as well as neurodegenerative diseases. Defects in the cholesterol trafficking are associated with enhanced generation of hyperphosphorylated Tau and Amyloid-β protei...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Nanjundaiah S,Chidambaram H,Chandrashekar M,Chinnathambi S

    更新日期:2020-05-28 00:00:00

  • Interaction between syntaxin 8 and HECTd3, a HECT domain ligase.

    abstract::Ubiquitination of proteins and their degradation within the proteasome has emerged as the major proteolytic mechanism used by mammalian cells to regulate cytosolic and nuclear protein levels. Substrate ubiquitylation is mediated by ubiquitin (Ub) ligases, also called E3 Ub ligases. HECT-E3 Ub ligases are characterized...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Zhang L,Kang L,Bond W,Zhang N

    更新日期:2009-02-01 00:00:00

  • Effect of Induction Time on the Proliferation and Differentiation of Induced Schwann-Like Cells from Adipose-Derived Stem Cells.

    abstract::To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

    更新日期:2020-10-01 00:00:00

  • PARK2 and PARK7 Gene Polymorphisms as Risk Factors Associated with Serum Element Concentrations and Clinical Symptoms of Parkinson's Disease.

    abstract::Besides clinical and imaging techniques, there is a lack of molecular makers for the diagnosis of Parkinson's disease (PD). There is an immense need to develop biomarkers associated with the phenotypes which may be valuable for individualized treatment. Single-nucleotide polymorphisms (PARK2: Ser167Asn (G>A) and Val38...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Sanyal J,Anirudhan A,Banerjee TK,Guha G,Ramakrishnan Veerabathiran,Murugesan R,Ahmed SSJS,Rao VR

    更新日期:2020-04-01 00:00:00

  • Quantitative analysis of delayed neuronal death in the hippocampal subfields of SHRSP and SHR.

    abstract::Transient forebrain ischemia and reperfusion induces delayed neuronal death (DND) in the hippocampal Cornu Ammonis 1 (CA1) subfield of stroke-prone spontaneously hypertensive rat (SHRSP). The vulnerability to DND is potentially related to the genetic susceptibility to stroke in this strain. To elucidate the mechanism ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Daisu M,Hatta T,Sakurai-Yamashita Y,Nabika T,Moritake K

    更新日期:2009-06-01 00:00:00

  • Peripheral nerve extract promotes long-term survival and neurite outgrowth in cultured spinal cord neurons.

    abstract::The hypothesis that peripheral, skeletal muscle tissue contains a trophic factor supporting central neurons has recently been investigated in vitro by supplementing the culture medium of spinal cord neurons with muscle extracts and fractions of extract. We extended these studies asking whether or not a trophic factor ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Popiela H,Porter T,Beach RL,Festoff BW

    更新日期:1984-03-01 00:00:00

  • Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6.

    abstract::Neuroinflammation is an integral part of neurodegenerative diseases. Lipo-polysacharide (LPS) induces reactive astrogliosis, the cellular manifestation of neuroinflammation, in various models of neurological diseases, but its mechanism of action is still not properly known. The effect of guggulipid and nimesulide on L...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Niranjan R,Nath C,Shukla R

    更新日期:2011-07-01 00:00:00

  • Cell-autonomous enhancement of glutamate-uptake by female astrocytes.

    abstract::Since gonadal female hormones act on and protect neurons, it is well known that the female brain is less vulnerable to stroke or other brain insults than the male brain. Although glial functions have been shown to affect the vulnerability of the brain, little is known if such a sex difference exists in glia, much less...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Morizawa Y,Sato K,Takaki J,Kawasaki A,Shibata K,Suzuki T,Ohta S,Koizumi S

    更新日期:2012-08-01 00:00:00

  • Alterations in cerebrospinal fluid uridine, hypoxanthine, and xanthine in head-injured patients.

    abstract::1. Examination of the cerebrospinal fluid (CSF) of head-injured patients reveals that the concentration of intraventricular xanthine is elevated and that of uridine is decreased relative to those of adult lumbar CSF. 2. No correlations were observed between CSF lactate and CSF hypoxanthine, xanthine, or uridine, sugge...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Mueller RA,Rosner MJ,Ghia JN,Powers SK,Kafer ER,Hunt RD

    更新日期:1988-06-01 00:00:00

  • Cannabinoid effects on β amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro.

    abstract::Cannabinoid (CB) ligands have demonstrated neuroprotective properties. In this study we compared the effects of a diverse set of CB ligands against β amyloid-mediated neuronal toxicity and activated microglial-conditioned media-based neurotoxicity in vitro, and compared this with a capacity to directly alter β amyloid...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Janefjord E,Mååg JL,Harvey BS,Smid SD

    更新日期:2014-01-01 00:00:00

  • Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat Light-Induced Retina Damage Model.

    abstract::Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

    更新日期:2017-01-01 00:00:00

  • Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures.

    abstract::: Oxidative stress has been implicated in a large number of human degenerative diseases, including epilepsy. Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy. Recently, it was demonstrated that the mechanism of LEV differs from that of conventional ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Oliveira AA,Almeida JP,Freitas RM,Nascimento VS,Aguiar LM,Júnior HV,Fonseca FN,Viana GS,Sousa FC,Fonteles MM

    更新日期:2007-05-01 00:00:00

  • A quantum dot probe conjugated with aβ antibody for molecular imaging of Alzheimer's disease in a mouse model.

    abstract::The treatment of Alzheimer's disease (AD) has been hampered by a lack of sensitive and specific non-invasive diagnostic methods. Quantum dots (QD) are nano-crystals with unique photo-physical properties that bypass some of the limitations of conventional dyes and imaging tools. This study is aimed to evaluate the fluo...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Feng L,Long HY,Liu RK,Sun DN,Liu C,Long LL,Li Y,Chen S,Xiao B

    更新日期:2013-08-01 00:00:00

  • Enhanced Neuroprotection of Minimally Invasive Surgery Joint Local Cooling Lavage against ICH-induced Inflammation Injury and Apoptosis in Rats.

    abstract::Hypothermia treatment is one of the neuroprotective strategies that improve neurological outcomes effectively after brain damage. Minimally invasive surgery (MIS) has been an important treatment of intracerebral hemorrhage (ICH). Herein, we evaluated the neuroprotective effect and mechanism of MIS joint local cooling ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Liu XC,Jing LY,Yang MF,Wang K,Wang Y,Fu XY,Fang J,Hou YJ,Sun JY,Li DW,Zhang ZY,Mao LL,Tang YM,Fu XT,Fan CD,Yang XY,Sun BL

    更新日期:2016-07-01 00:00:00