Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells.

abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

journal_title：Cellular and molecular neurobiology

authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

更新日期：1998-08-01 00:00:00

abstract：:The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to reduce stress responses. Acute restraint stress (ARS) is a stress mo...

journal_title：Cellular and molecular neurobiology

authors： Brasil TFS,Fassini A,Corrêa FM

更新日期：2018-01-01 00:00:00

abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

journal_title：Cellular and molecular neurobiology

authors： Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

更新日期：2004-06-01 00:00:00

abstract：:Since gonadal female hormones act on and protect neurons, it is well known that the female brain is less vulnerable to stroke or other brain insults than the male brain. Although glial functions have been shown to affect the vulnerability of the brain, little is known if such a sex difference exists in glia, much less...

journal_title：Cellular and molecular neurobiology

authors： Morizawa Y,Sato K,Takaki J,Kawasaki A,Shibata K,Suzuki T,Ohta S,Koizumi S

更新日期：2012-08-01 00:00:00

abstract：:We have previously demonstrated that alpha2-adrenoceptors regulate hypothalamic magnocellular oxytocinergic (OXY) neurons in Sprague Dawley rats. Here we investigated whether activation/inhibition of alpha2-adrenoceptors may similarly trigger/downregulate the activity of OXY neurons in control Long Evans (+/+) and per...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2009-09-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:The L-type calcium channel blocker nimodipine improves clinical outcome produced by delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While vasoactive mechanisms are strongly implicated in these therapeutic actions of nimodipine, we sought to test whether nimodipine might also regulate ne...

journal_title：Cellular and molecular neurobiology

authors： Koskimäki J,Matsui N,Umemori J,Rantamäki T,Castrén E

更新日期：2015-03-01 00:00:00

abstract：:1. Synaptic vesicles (SVs) mediate fast regulated secretion of classical neurotransmitters. In order to perform their task SVs rely on a restrict set of membrane proteins. The mechanisms responsible for targeting these proteins to the SV membrane are still poorly understood. 2. Likewise, little is known about the intr...

journal_title：Cellular and molecular neurobiology

authors： Prado VF,Prado MA

更新日期：2002-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes permanent neurological and cognitive impairments. Effective pharmacological interventions remain elusive. Spermidine is a polyamine compound found in our body that may play a role in brain development and congenital function. In this study, we aimed to investigate the therapeutic po...

journal_title：Cellular and molecular neurobiology

authors： Huang J,Zhang H,Zhang J,Yu H,Lin Z,Cai Y

更新日期：2020-08-01 00:00:00

abstract：:1. Gonadotropin-releasing hormone (GnRH) was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, during evolution the peptide was subject to gene duplication and structural changes, and multiple m...

journal_title：Cellular and molecular neurobiology

authors： King JA,Millar RP

更新日期：1995-02-01 00:00:00

abstract：:1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second mess...

journal_title：Cellular and molecular neurobiology

authors： Winkler H,Fischer-Colbrie R

更新日期：1998-04-01 00:00:00

abstract：:: Oxidative stress has been implicated in a large number of human degenerative diseases, including epilepsy. Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy. Recently, it was demonstrated that the mechanism of LEV differs from that of conventional ...

journal_title：Cellular and molecular neurobiology

authors： Oliveira AA,Almeida JP,Freitas RM,Nascimento VS,Aguiar LM,Júnior HV,Fonseca FN,Viana GS,Sousa FC,Fonteles MM

更新日期：2007-05-01 00:00:00

abstract：:The myelin-associated inhibitor/Nogo-66 receptor 1 (NgR1) pathway directly functions in negative modulation of structural and electrophysiological synaptic plasticity. A previous study has established an important role of NgR1 pathway signaling in cognitive function, and we have demonstrated that multiple components o...

journal_title：Cellular and molecular neurobiology

authors： VanGuilder Starkey HD,Bixler GV,Sonntag WE,Freeman WM

更新日期：2013-05-01 00:00:00

abstract：:The hematopoietic cell kinase (Hck) is a member of the Src family protein kinases which regulates many signal transduction pathways including cell growth, proliferation, differentiation, migration, and apoptosis. However, the expression and function of Hck after intracerebral hemorrhage (ICH) are unknown. Western blot...

journal_title：Cellular and molecular neurobiology

authors： Wang J,Chen R,Liu X,Shen J,Yan Y,Gao Y,Tao T,Shi J

更新日期：2017-03-01 00:00:00

abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

journal_title：Cellular and molecular neurobiology

authors： Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

更新日期：1998-06-01 00:00:00

abstract：:The expression of muscarinic acetylcholine binding sites and of cholinesterases was studied in extracts prepared from discrete regions of the human fetal brain, between the gestational ages of 14 and 24 weeks. The specific binding of [3H]N-methyl-4-piperidyl benzilate [( 4H]-4NMPB) to muscarinic binding sites ranged b...

journal_title：Cellular and molecular neurobiology

authors： Egozi Y,Sokolovsky M,Schejter E,Blatt I,Zakut H,Matzkel A,Soreq H

更新日期：1986-03-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs which mediate post-transcriptional gene regulation. Recently, microRNAs have also been found to be localized to the extracellular space, often encapsulated in secreted extracellular vesicles (EVs). This tandem of EVs and tissue-specific expressed/secreted microRNAs that can be taken...

journal_title：Cellular and molecular neurobiology

authors： Bronisz A,Godlewski J,Chiocca EA

更新日期：2016-04-01 00:00:00

abstract：:Podoplanin (PDPN) is a mucin-type transmembrane sialoglycoprotein expressed in multiple tissues in adult animals, including the brain, lungs, kidney, and lymphoid organs. Studies of this molecule have demonstrated its great importance in tumor metastasis, platelet aggregation, and lymphatic vessel formation. However, ...

journal_title：Cellular and molecular neurobiology

authors： Song Y,Shen J,Lin Y,Shen J,Wu X,Yan Y,Zhou L,Zhang H,Zhou Y,Cao M,Liu Y

更新日期：2014-08-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)), a major reactive oxygen species produced during oxidative stress, has been implicated in the pathophysiology of various neurodegenerative conditions. Cyperus rotundus is a traditional medicinal herb that has recently found applications in food and confectionary industries. In the current ...

journal_title：Cellular and molecular neurobiology

authors： Kumar KH,Khanum F

更新日期：2013-01-01 00:00:00

abstract：:1. Effects of pentosan polysulfate (PPS) and the structurally related sulfated polyanions dextran sulfate, fucoidan, and heparin on the scavenger receptor-mediated and fluidphase endocytosis in GP8 immortalized rat brain endothelial cells were investigated. 2. Using 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarboxyamin...

journal_title：Cellular and molecular neurobiology

authors： Deli MA,Abrahám CS,Takahata H,Katamine S,Niwa M

更新日期：2000-12-01 00:00:00

abstract：:1. Differential regulation, by dexamethasone, of glucocorticoid receptor gene expression was studied in three different neuronal cultures derived from hypothalamus amygdala, and cerebral cortex. 2. Cellular glucocorticoid receptor (GR) mRNA concentration was measured by hybridization using a 32P-labeled RNA probe comp...

journal_title：Cellular and molecular neurobiology

authors： Pepin MC,Beaulieu S,Barden N

更新日期：1990-06-01 00:00:00

abstract：:Reeler heterozygous mice (reln+/-) are seemingly normal but haplodeficient in reln, a gene implicated in autism. Structural/neurochemical alterations in the reln+/- brain are subtle and difficult to demonstrate. Therefore, the usefulness of these mice in translational research is still debated. As evidence implicated ...

journal_title：Cellular and molecular neurobiology

authors： Castagna C,Merighi A,Lossi L

更新日期：2019-08-01 00:00:00

abstract：:Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

journal_title：Cellular and molecular neurobiology

authors： Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

更新日期：2017-01-01 00:00:00

abstract：:P2X3 receptor expression in various tissues appears to be modulated by age. In the present study, we used single cell RT-PCR to determine the number of P2X3 positive myenteric neurons at different stages of guinea pig postnatal development, and we tested if similar changes also occur to other myenteric P2X receptors. ...

journal_title：Cellular and molecular neurobiology

authors： Loera-Valencia R,Jiménez-Vargas NN,Villalobos EC,Juárez EH,Lomas-Ramos TL,Espinosa-Luna R,Montaño LM,Huizinga JD,Barajas-López C

更新日期：2014-07-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new p...

journal_title：Cellular and molecular neurobiology

authors： Fachel FNS,Dal Prá M,Azambuja JH,Endres M,Bassani VL,Koester LS,Henriques AT,Barschak AG,Teixeira HF,Braganhol E

更新日期：2020-01-01 00:00:00

abstract：:The effects of the calcium channel blocker D-600 on the cation channels activated by acetylcholine (ACh) was studied in voltage-clamped Aplysia neurons by voltage-jump relaxation analysis. D-600 blocked the steady-state ACh current in a highly voltage-dependent manner, the degree of antagonism increasing with membrane...

journal_title：Cellular and molecular neurobiology

authors： Slater NT,Haas HL,Carpenter DO

更新日期：1983-12-01 00:00:00

abstract：:Inhibitory mechanism of cerebellum epileptic activity can be involved depending on the intensity and frequency of seizure convulsions. N-methyl-D-aspartate receptors (NMDARs) play key roles in excitatory synaptic transmission and have been implicated in neurological disorders: in cerebellum, they have specific charact...

journal_title：Cellular and molecular neurobiology

authors： Girardi E,Auzmendi J,Charó N,Gori MB,Castro M

更新日期：2010-10-01 00:00:00

abstract：:1. The analogies between the processing of amyloid precursor protein (APP) and other transmembrane sterol regulatory element binding proteins (SREBPs) inspired us to conduct further studies on whether beta-amyloid (Abeta) affects aromatase by interacting with APP and SREBP. 2. In this study, cultured human neuroblasto...

journal_title：Cellular and molecular neurobiology

authors： Kelicen P,Nordberg A

更新日期：2006-05-01 00:00:00

abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

journal_title：Cellular and molecular neurobiology

authors： Takadera T,Ohyashiki T

更新日期：2007-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the ...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Zhu M,He ZZ

更新日期：2016-11-01 00:00:00