Abstract:
:The hematopoietic cell kinase (Hck) is a member of the Src family protein kinases which regulates many signal transduction pathways including cell growth, proliferation, differentiation, migration, and apoptosis. However, the expression and function of Hck after intracerebral hemorrhage (ICH) are unknown. Western blot, immunohistochemistry, and immunofluorescence showed that Hck was obviously up-regulation in neurons adjacent to the hematoma after ICH. In addition, the temporary raise of Hck expression was paralleled with the expression of p53, Bax, and active caspase-3, suggesting that Hck was involved in neuronal apoptosis. Hck siRNA dramatically decrease hemin-induced expression of p53, Bax, and active caspase-3 as well as the amount of apoptotic SH-SY5Y cells in vitro. Furthermore, Hck interacted with p53. Hence, Hck might promote neuronal apoptosis via p53 signaling pathway after ICH.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Wang J,Chen R,Liu X,Shen J,Yan Y,Gao Y,Tao T,Shi Jdoi
10.1007/s10571-016-0365-0subject
Has Abstractpub_date
2017-03-01 00:00:00pages
251-261issue
2eissn
0272-4340issn
1573-6830pii
10.1007/s10571-016-0365-0journal_volume
37pub_type
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