Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage.

Abstract:

:The hematopoietic cell kinase (Hck) is a member of the Src family protein kinases which regulates many signal transduction pathways including cell growth, proliferation, differentiation, migration, and apoptosis. However, the expression and function of Hck after intracerebral hemorrhage (ICH) are unknown. Western blot, immunohistochemistry, and immunofluorescence showed that Hck was obviously up-regulation in neurons adjacent to the hematoma after ICH. In addition, the temporary raise of Hck expression was paralleled with the expression of p53, Bax, and active caspase-3, suggesting that Hck was involved in neuronal apoptosis. Hck siRNA dramatically decrease hemin-induced expression of p53, Bax, and active caspase-3 as well as the amount of apoptotic SH-SY5Y cells in vitro. Furthermore, Hck interacted with p53. Hence, Hck might promote neuronal apoptosis via p53 signaling pathway after ICH.

journal_name

Cell Mol Neurobiol

authors

Wang J,Chen R,Liu X,Shen J,Yan Y,Gao Y,Tao T,Shi J

doi

10.1007/s10571-016-0365-0

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

251-261

issue

2

eissn

0272-4340

issn

1573-6830

pii

10.1007/s10571-016-0365-0

journal_volume

37

pub_type

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