The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1.

abstract：:Neuropathic pain occurs as a result of peripheral or central nervous system injury. Its pathophysiology involves mainly a central sensitization mechanism that may be correlated to many molecules acting in regions involved in pain processing, such as the spinal cord. It has been demonstrated that reactive oxygen specie...

journal_title：Cellular and molecular neurobiology

authors： Guedes RP,Araújo AS,Janner D,Belló-Klein A,Ribeiro MF,Partata WA

更新日期：2008-12-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new p...

journal_title：Cellular and molecular neurobiology

authors： Fachel FNS,Dal Prá M,Azambuja JH,Endres M,Bassani VL,Koester LS,Henriques AT,Barschak AG,Teixeira HF,Braganhol E

更新日期：2020-01-01 00:00:00

abstract：:Glial cells have various important roles in regulation of brain functions. For such events, extracellular nucleotides/P2 receptors have central roles. Although there have been huge amount of literature about activation of P2 receptors and glial functions, little is known about what happens in glia or the brain if glia...

journal_title：Cellular and molecular neurobiology

authors： Kinoshita M,Nasu-Tada K,Fujishita K,Sato K,Koizumi S

更新日期：2013-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

journal_title：Cellular and molecular neurobiology

authors： Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

更新日期：2020-10-30 00:00:00

abstract：:Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

journal_title：Cellular and molecular neurobiology

authors： Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

更新日期：2017-03-01 00:00:00

abstract：:Exposing bovine chromaffin cells to a single 5 ns, high-voltage (5 MV/m) electric pulse stimulates Ca(2+) entry into the cells via L-type voltage-gated Ca(2+) channels (VGCC), resulting in the release of catecholamine. In this study, fluorescence imaging was used to monitor nanosecond pulse-induced effects on intracel...

journal_title：Cellular and molecular neurobiology

authors： Craviso GL,Choe S,Chatterjee P,Chatterjee I,Vernier PT

更新日期：2010-11-01 00:00:00

abstract：:Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction...

journal_title：Cellular and molecular neurobiology

authors： Shtark MB,Gainutdinov KL,Khichenko VI,Starostina MV

更新日期：1981-09-01 00:00:00

abstract：:1. Amphetamine-induced c-fos and egr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological acti...

journal_title：Cellular and molecular neurobiology

authors： Chiasson BJ,Armstrong JN,Hooper ML,Murphy PR,Robertson HA

更新日期：1994-10-01 00:00:00

abstract：:1. It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTM intact for the same task in the same animal. 2. The effect of a lar...

journal_title：Cellular and molecular neurobiology

authors： Izquierdo LA,Barros DM,Vianna MR,Coitinho A,deDavid e Silva T,Choi H,Moletta B,Medina JH,Izquierdo I

更新日期：2002-06-01 00:00:00

abstract：:The aim of this review was to give a general aspect of the sensorial function of the striatum related to pain modulation, which was intensively studied in our laboratory. We analyse the effect of electrical and chemical stimulation of the striatum on the orofacial pain, especially that produced by tooth pulp stimulati...

journal_title：Cellular and molecular neurobiology

authors： Barceló AC,Filippini B,Pazo JH

更新日期：2012-01-01 00:00:00

abstract：:1. The electrophysiological actions of excitatory amino acids and serotonin were investigated in slices from cat neocortex in vitro. Intracellular recordings were obtained from neurons (mainly in layer V) and the drugs applied extracellularly to the same neurons by microiontophoresis. 2. Serotonin, and to some extent ...

journal_title：Cellular and molecular neurobiology

authors： Nedergaard S,Engberg I,Flatman JA

更新日期：1987-12-01 00:00:00

abstract：:1. The visual transduction system of the vertebrate retina is a well-studied model for biochemical and molecular studies of signal transduction. The structure and function of rhodopsin, a prototypical G protein-coupled receptor, and transducin or Gt, the photoreceptor G protein, have been particularly well studied. Me...

journal_title：Cellular and molecular neurobiology

authors： Hamm HE

更新日期：1991-12-01 00:00:00

abstract：:Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated...

journal_title：Cellular and molecular neurobiology

authors： Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

更新日期：2005-12-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

journal_title：Cellular and molecular neurobiology

authors： Xiang H,Tao W,Wang L,Wang F,Xu A

更新日期：2008-12-01 00:00:00

abstract：:: Oxidative stress has been implicated in a large number of human degenerative diseases, including epilepsy. Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy. Recently, it was demonstrated that the mechanism of LEV differs from that of conventional ...

journal_title：Cellular and molecular neurobiology

authors： Oliveira AA,Almeida JP,Freitas RM,Nascimento VS,Aguiar LM,Júnior HV,Fonseca FN,Viana GS,Sousa FC,Fonteles MM

更新日期：2007-05-01 00:00:00

abstract：:Spinal cord injury (SCI) remains a formidable challenge in the clinic. In the current study, we examined the effects of the TLX gene on the proliferation and neuronal differentiation of dermal multipotent stem cells (DMSCs) in vitro and the potential of these cells to improve SCI in rats in vivo. DMSCs were stably tra...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Ren X,Xiong J,Zhang L,Qu J,Xu W

更新日期：2011-04-01 00:00:00

abstract：:1. Antidepressants have been used clinically for many years; however, the neurochemical mechanism for their therapeutic effect has not been clarified yet. Recent reports indicate that chronic antidepressant treatment directly affects the postsynaptic membrane to increase the coupling between the stimulatory GTP-bindin...

journal_title：Cellular and molecular neurobiology

authors： Kamada H,Saito T,Hatta S,Toki S,Ozawa H,Watanabe M,Takahata N

更新日期：1999-02-01 00:00:00

abstract：:Phenylketonuria (PKU) is an inherited metabolic disorder caused by deficiency of phenylalanine hydroxylase which leads to accumulation of phenylalanine and its metabolites in tissues of patients with severe neurological involvement. Recently, many studies in animal models or patients have reported the role of oxidativ...

journal_title：Cellular and molecular neurobiology

authors： Moraes TB,Jacques CE,Rosa AP,Dalazen GR,Terra M,Coelho JG,Dutra-Filho CS

更新日期：2013-03-01 00:00:00

abstract：:The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2008-12-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesi...

journal_title：Cellular and molecular neurobiology

authors： Nampoothiri SS,Rajanikant GK

更新日期：2019-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of nigrostriatal dopaminergic neurons. However, the molecular pathways leading to the dopaminergic neuron degeneration have remained obscure until recently. Reports demonstrated that reduction of b...

journal_title：Cellular and molecular neurobiology

authors： Yuan Y,Sun J,Zhao M,Hu J,Wang X,Du G,Chen NH

更新日期：2010-08-01 00:00:00

abstract：:Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The opioid epidemic in the USA has highlighted the need for alternative treatments for pain. Following reports on the opioid interactions of various antipsychotic medications, we speculated that the inv...

journal_title：Cellular and molecular neurobiology

authors： Schreiber S,Pick CG

更新日期：2020-11-13 00:00:00

abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

journal_title：Cellular and molecular neurobiology

authors： Rutigliano G,Zucchi R

更新日期：2020-03-01 00:00:00

abstract：:Methylmalonic acidemia and propionic acidemia are organic acidemias biochemically characterized by predominant tissue accumulation of methylmalonic acid (MMA) and propionic acid (PA), respectively. Affected patients present predominantly neurological symptoms, whose pathogenesis is not yet fully established. In the pr...

journal_title：Cellular and molecular neurobiology

authors： Fernandes CG,Borges CG,Seminotti B,Amaral AU,Knebel LA,Eichler P,de Oliveira AB,Leipnitz G,Wajner M

更新日期：2011-07-01 00:00:00

abstract：:In order to guarantee better conditions for competition, the nervous system has developed not only mechanisms controlling muscle effectors, but also retrograde systems that, starting from peripheral structures, may influence brain functions. Under such perspective, physical activity could play an important role in inf...

journal_title：Cellular and molecular neurobiology

authors： Lista I,Sorrentino G

更新日期：2010-05-01 00:00:00

abstract：:1. Angiotensin II receptors have been studied by quantitative autoradiography in selected brain areas of young (2-week-old) and adult (8-week-old) rats. 2. In young rats, angiotensin II receptors were present in brain areas which did not express receptors in the adult brain, such as thalamic nuclei, cortical areas, an...

journal_title：Cellular and molecular neurobiology

authors： Tsutsumi K,Saavedra JM

更新日期：1991-04-01 00:00:00

abstract：:1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second mess...

journal_title：Cellular and molecular neurobiology

authors： Winkler H,Fischer-Colbrie R

更新日期：1998-04-01 00:00:00

abstract：:Agmatine is an endogenous amine that is synthesized following the decarboxylation of L-arginine by arginine decarboxylase. Agmatine exists in mammalian brain and has been proposed as a neurotransmitter and/or neurotransmodulator. Agmatine binds to several targets and is considered as an endogenous ligand for imidazoli...

journal_title：Cellular and molecular neurobiology

authors： Wu N,Su RB,Li J

更新日期：2008-08-01 00:00:00