The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1.

abstract：AIM:A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS:Electron microscop...

journal_title：Cellular and molecular neurobiology

authors： Sombers LA,Maxson MM,Ewing AG

更新日期：2007-08-01 00:00:00

abstract：:Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

journal_title：Cellular and molecular neurobiology

authors： Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

更新日期：2019-07-01 00:00:00

abstract：:Membrane responses to cyclic adenosine monophosphate (cAMP) injections have been studied by means of voltage clamp, Ca-indicator dye, and ion substitution techniques in identified neurons from the abdominal ganglion of Limax maximus. The ventral abdominal giant cell (AGC) displayed a response consisting of a decrease ...

journal_title：Cellular and molecular neurobiology

authors： Hockberger P,Connor JA

更新日期：1984-12-01 00:00:00

abstract：:Cerebral hemorrhage is a series of devastating cerebrovascular diseases with high mortality, morbidity and recurrence rate. Localized and systemic immuno-reactions are involved. Aggregation of immunocytes, which were both recruited from the peripheral circulation and resident in the central nervous system, is induced ...

journal_title：Cellular and molecular neurobiology

authors： Ye L,Gao L,Cheng H

更新日期：2018-10-01 00:00:00

abstract：:Spinal cord libraries subtracted against visual cortex using suppression subtractive hybridization SSH are dominated by abundant gene sequences derived from myelin elements. We compared our subtracted library results of three of these abundant sequences to published expressed sequence tag libraries that are not normal...

journal_title：Cellular and molecular neurobiology

authors： Lathia KB,Yan Z,Clapshaw PA

更新日期：2009-12-01 00:00:00

abstract：:Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice prov...

journal_title：Cellular and molecular neurobiology

authors： Zhang ZH,Zhao WQ,Ma FF,Zhang H,Xu XH

更新日期：2017-10-01 00:00:00

abstract：:1. Amphetamine-induced c-fos and egr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological acti...

journal_title：Cellular and molecular neurobiology

authors： Chiasson BJ,Armstrong JN,Hooper ML,Murphy PR,Robertson HA

更新日期：1994-10-01 00:00:00

abstract：:1. Wobbler mice suffer an autosomal recessive mutation producing severe motoneuron degeneration and dense astrogliosis, with increased levels of glial fibrillary acidic protein (GFAP) in the spinal cord and brain stem. They have been considered animal models of amyotrophic lateral sclerosis and infantile spinal muscul...

journal_title：Cellular and molecular neurobiology

authors： Gonzalez Deniselle MC,Gonzalez SL,Piroli GG,Lima AE,De Nicola AF

更新日期：1996-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the ...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Zhu M,He ZZ

更新日期：2016-11-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2008-12-01 00:00:00

abstract：:Diabetic retinopathy (DR) is widely recognized as a neurovascular disease. Retina, being a neuronal tissue of the eye, produces neurotrophic factors for its maintenance. However, diabetes dysregulates their levels and thereby may damage the retina. Among neurotrophins, brain derived neurotrophic factor (BDNF) is the m...

journal_title：Cellular and molecular neurobiology

authors： Ola MS,Nawaz MI,El-Asrar AA,Abouammoh M,Alhomida AS

更新日期：2013-04-01 00:00:00

abstract：:Thyroid hormone (T(3)) plays an essential role in the central nervous system development. Astrocytes mediate many of the T(3) effects in the growth and differentiation of cerebellum. In culture, T(3) induces cerebellar astrocytes to secrete growth factors, mainly FGF(2), and alters the expression and organization of t...

journal_title：Cellular and molecular neurobiology

authors： Mendes-de-Aguiar CB,Costa-Silva B,Alvarez-Silva M,Tasca CI,Trentin AG

更新日期：2008-09-01 00:00:00

abstract：:While light is the basic element for inducing vision and modulating circadian rhythms, excessive light has been reported to have a negative effect on the survival of various types of retinal cells. Among them photoreceptors and retinal pigment epithelial (RPE) cells degeneration after light exposure is widely observed...

journal_title：Cellular and molecular neurobiology

authors： Zhao Y,Shen Y

更新日期：2020-11-01 00:00:00

abstract：:Fractalkine (CX3CL1) is a potent inflammatory mediator of the central nervous system, which is expressed by neurons and regulates microglial functions by binding to fractalkine receptor (CX3CR1). It has been demonstrated that neuroinflammation plays an important role in iron accumulation of the brain leading to neuron...

journal_title：Cellular and molecular neurobiology

authors： Pandur E,Tamási K,Pap R,Varga E,Miseta A,Sipos K

更新日期：2019-10-01 00:00:00

abstract：:1. Neural angiotensinergic circuitry located in the lamina terminalis has been proposed to be involved in blood pressure regulation and fluid homeostasis. 2. ANG II binding sites have been described to be localized throughout the lamina terminalis including the subfornical organ (SFO), the median preoptic nucleus (MnP...

journal_title：Cellular and molecular neurobiology

authors： Guilhaume SS,Corrêa FM

更新日期：2001-02-01 00:00:00

abstract：:Reeler heterozygous mice (reln+/-) are seemingly normal but haplodeficient in reln, a gene implicated in autism. Structural/neurochemical alterations in the reln+/- brain are subtle and difficult to demonstrate. Therefore, the usefulness of these mice in translational research is still debated. As evidence implicated ...

journal_title：Cellular and molecular neurobiology

authors： Castagna C,Merighi A,Lossi L

更新日期：2019-08-01 00:00:00

abstract：:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly acc...

journal_title：Cellular and molecular neurobiology

authors： Layer PG

更新日期：1991-02-01 00:00:00

abstract：:1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTP gamma S, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were st...

journal_title：Cellular and molecular neurobiology

authors： Heemskerk FM,Zorad S,Xu N,Gutkind SJ,Saavedra JM

更新日期：1999-04-01 00:00:00

abstract：:Oxidative glutamate toxicity plays a vital role in the neurodegeneration diseases, including Alzheimer's diseases (AD). This study set out with the aim to investigate the beneficial effects of fangchinoline (FAN), a natural alkaloid, against glutamate-induced oxidative damage, and to clarify the underlying cellular an...

journal_title：Cellular and molecular neurobiology

authors： Bao F,Tao L,Zhang H

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study. METHODS:First, the proteins of CSF from MS patients and control group were analyzed individually with 2D-DIGE...

journal_title：Cellular and molecular neurobiology

authors： Qin Z,Qin Y,Liu S

更新日期：2009-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

journal_title：Cellular and molecular neurobiology

authors： Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

更新日期：2017-04-01 00:00:00

abstract：:(1) Axons contain numerous mRNAs and a local protein synthetic system that can be regulated independently of the cell body. (2) In this study, cultured primary sympathetic neurons were employed, to assess the effect of local protein synthesis blockade on axon viability and mitochondrial function. (3) Inhibition of loc...

journal_title：Cellular and molecular neurobiology

authors： Hillefors M,Gioio AE,Mameza MG,Kaplan BB

更新日期：2007-09-01 00:00:00

abstract：:1. The aims of the present study were (a) to determine the identity of the G proteins with which the endothelin receptor interacts and whether this interaction is subtype specific and (b) to determine whether agonist exposure can result in specific coupling between the endothelin receptor and G proteins. 2. Coupling b...

journal_title：Cellular and molecular neurobiology

authors： Shraga-Levine Z,Sokolovsky M

更新日期：2000-06-01 00:00:00

abstract：:We demonstrated synchronous oscillation of intracellular Ca2+ in cultured-mouse mid-brain neurons. This synchronous oscillation was thought to result from spontaneous and synchronous neural bursts in a synaptic neural network. We also examined the role of endogenous dopamine in neural networks showing synchronous osci...

journal_title：Cellular and molecular neurobiology

authors： Yasumoto F,Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

更新日期：2004-02-01 00:00:00

abstract：:In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the...

journal_title：Cellular and molecular neurobiology

authors： Yan BC,Park JH,Kim SK,Choi JH,Lee CH,Yoo KY,Kwon YG,Kim YM,Kim JD,Won MH

更新日期：2012-11-01 00:00:00

abstract：:The effects of the divalent cations Ca and Mg on the properties of ACh-activated channels at the frog neuromuscular junction were studied using a two-microelectrode voltage clamp. The divalent cation concentration was varied from 2 to 40 mM in solutions containing 50% normal Na. The reversal potential was determined b...

journal_title：Cellular and molecular neurobiology

authors： Lewis CA

更新日期：1984-09-01 00:00:00

abstract：:1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

journal_title：Cellular and molecular neurobiology

authors： Platt B,Büsselberg D

更新日期：1994-12-01 00:00:00

abstract：:Levels of cyclic nucleotides and ornithine decarboxylase (ODC) activity were examined following the application of various kinds of stimuli to superior cervical sympathetic ganglia (SCG), nodose ganglia, and vagus nerve fibers excised from the rat. The level of cyclic GMP in the SCG rose rapidly to about 4.5- to 7.5-f...

journal_title：Cellular and molecular neurobiology

authors： Ando M,Miwa M,Nagata Y

更新日期：1984-03-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

journal_title：Cellular and molecular neurobiology

authors： Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

更新日期：2020-10-30 00:00:00