The striatum and pain modulation.

Abstract:

:The aim of this review was to give a general aspect of the sensorial function of the striatum related to pain modulation, which was intensively studied in our laboratory. We analyse the effect of electrical and chemical stimulation of the striatum on the orofacial pain, especially that produced by tooth pulp stimulation of the lower incisors. We demonstrated specific sites within the nucleus which electrical or chemical stimulation produced inhibition of the nociceptive jaw opening reflex. This analgesic action of the striatum was mediated by activation of its dopamine D(2) receptors and transmitted through the indirect pathways of the basal ganglia and the medullary dorsal reticular nucleus (RVM) to the sensorial nuclei of the trigeminal nerve. Its mechanism of action was by inhibition of the nociceptive response of the second order neurons of the nucleus caudalis of the V par.

journal_name

Cell Mol Neurobiol

authors

Barceló AC,Filippini B,Pazo JH

doi

10.1007/s10571-011-9737-7

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1-12

issue

1

eissn

0272-4340

issn

1573-6830

journal_volume

32

pub_type

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