Abstract:
:1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional expression of HVA Ca2+ channels in the PC12 cell line model system. Negligible inhibition of Ca2+ channel activity was observed after acute treatment, but a significant decrease in Ca2+ current amplitude was promoted by chronic exposure to GBP. 3. Consistent with this, radioligand binding experiments showed a comparable reduction in the total number of membrane HVA N-type channels after GBP treatment.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Vega-Hernández A,Felix Rdoi
10.1023/a:1019865822069subject
Has Abstractpub_date
2002-04-01 00:00:00pages
185-90issue
2eissn
0272-4340issn
1573-6830journal_volume
22pub_type
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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doi:10.1007/s10571-009-9473-4
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journal_title:Cellular and molecular neurobiology
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doi:10.1007/s10571-010-9618-5
更新日期:2011-03-01 00:00:00
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s10571-020-01001-2
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Cellular and molecular neurobiology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00