Opioid effects in developing rat vas deferens.

Abstract:

:The inhibitory effects of various opiates on developing rat vas deferens were studied by determining the degree of depression of mechanical responses elicited by electrical field stimulation. All agonists showed decreased effects with maturation, but the decrease occurred at different times. With normorphine the loss of agonist activity was greatest at days 12-16, while with D-Met2,Pro5-enkephalinamide it was greatest at days 16-30. beta-Endorphin also was less effective in adult than 30-day preparations, but methionine enkephalin was ineffective at all ages. Morphine and normorphine were weak antagonists of opiate agonists in the adult preparations. These results indicate that the nature and pharmacologic sensitivity of opiate actions change with development.

journal_name

Cell Mol Neurobiol

authors

Rónai AZ,Berzétei IP,Kurgyis J

doi

10.1007/BF00716268

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

335-42

issue

4

eissn

0272-4340

issn

1573-6830

journal_volume

1

pub_type

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