Mice with disrupted TGFbeta signaling have normal cerebella development, but exhibit facial dysmorphogenesis and strain-dependent deficits in their body wall.

abstract：:Exposure to stress induces profound physiological and behavioral changes in the organisms and some of these changes may be important regarding stress-induced pathologies and animal models of psychiatric diseases. Consequences of stress are dependent on the duration of exposure to stressors (acute, chronic), but also o...

journal_title：Cellular and molecular neurobiology

authors： Armario A,Daviu N,Muñoz-Abellán C,Rabasa C,Fuentes S,Belda X,Gagliano H,Nadal R

更新日期：2012-07-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new p...

journal_title：Cellular and molecular neurobiology

authors： Fachel FNS,Dal Prá M,Azambuja JH,Endres M,Bassani VL,Koester LS,Henriques AT,Barschak AG,Teixeira HF,Braganhol E

更新日期：2020-01-01 00:00:00

abstract：:Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceabl...

journal_title：Cellular and molecular neurobiology

authors： Kontro P,Oja SS

更新日期：1983-06-01 00:00:00

abstract：:1. Examination of the cerebrospinal fluid (CSF) of head-injured patients reveals that the concentration of intraventricular xanthine is elevated and that of uridine is decreased relative to those of adult lumbar CSF. 2. No correlations were observed between CSF lactate and CSF hypoxanthine, xanthine, or uridine, sugge...

journal_title：Cellular and molecular neurobiology

authors： Mueller RA,Rosner MJ,Ghia JN,Powers SK,Kafer ER,Hunt RD

更新日期：1988-06-01 00:00:00

abstract：:Dideoxycytidine (zalcitabine, ddC) produces neurotoxic effects. It is particularly important to understand the toxic effects of ddC on different subpopulations of dorsal root ganglion (DRG) neurons which express distinct tyrosine kinase receptor (Trk) and to find therapeutic factors for prevention and therapy for ddC-...

journal_title：Cellular and molecular neurobiology

authors： Liu H,Lu J,He Y,Yuan B,Li Y,Li X

更新日期：2014-03-01 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1), a member of the matrix metalloproteinases family, plays an integral role in extracellular matrix degradation and has been reportedly involved in the regulation of the brain or spinal cord traumatic neurovascular remodeling. Although the critical involvement of MMP-1 in the metastasi...

journal_title：Cellular and molecular neurobiology

authors： Zhou Y,Cui Z,Xia X,Liu C,Zhu X,Cao J,Wu Y,Zhou L,Ben Z,Song Y,Zhang H,Zhang D

更新日期：2014-11-01 00:00:00

abstract：:The insulin-like growth factor (IGF) system is linked to CNS pathological states. The functions of IGFs are modulated by a family of binding proteins termed insulin-like growth factor binding proteins (IGFBPs). Here, we demonstrate that IGFBP-6 may be associated with neuronal apoptosis in the processes of intracerebra...

journal_title：Cellular and molecular neurobiology

authors： Dai Q,Jiang P,Gu Y,Zhu L,Dai H,Yao Z,Liu H,Ma X,Duan C,Qu L

更新日期：2017-10-01 00:00:00

abstract：:The expression of muscarinic acetylcholine binding sites and of cholinesterases was studied in extracts prepared from discrete regions of the human fetal brain, between the gestational ages of 14 and 24 weeks. The specific binding of [3H]N-methyl-4-piperidyl benzilate [( 4H]-4NMPB) to muscarinic binding sites ranged b...

journal_title：Cellular and molecular neurobiology

authors： Egozi Y,Sokolovsky M,Schejter E,Blatt I,Zakut H,Matzkel A,Soreq H

更新日期：1986-03-01 00:00:00

abstract：:Compound 511 (511) is specially developed for opioid addiction treatment based on the Ancient Chinese drug rehabilitation literature, and its composition has profound effects in the treatment of drug addiction in various clinical trials and animal experiments. The effect of 511 on the rewarding properties of morphine ...

journal_title：Cellular and molecular neurobiology

authors： Zhang H,Wang Q,Sun Q,Qin F,Nie D,Li Q,Gu Y,Jiang Y,Lu S,Lu Z

更新日期：2020-04-22 00:00:00

abstract：:1. Alpha-synuclein is known to play an important role in the pathogenesis of Parkinson's disease (PD). The pathogenicity of alpha-synuclein is related to its ability to form intraneuronal inclusions. The inclusions, which are found in brains of patients with PD and diffuse Lewy body disease consist partially of C-term...

journal_title：Cellular and molecular neurobiology

authors： Zach S,Bueler H,Hengerer B,Gillardon F

更新日期：2007-06-01 00:00:00

abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

journal_title：Cellular and molecular neurobiology

authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

更新日期：2010-01-01 00:00:00

abstract：:1. The expression of monocyte chemoattractant protein-1 (MCP-1) was examined in stroke-prone spontaneously hypertensive rats with transient global ischemia in order to study the involvement of the infiltration of blood monocytes in the mechanism of ischemia-related neuronal death. 2. The brains of the animals with occ...

journal_title：Cellular and molecular neurobiology

authors： Sakurai-Yamashita Y,Shigematsu K,Yamashita K,Niwa M

更新日期：2006-07-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant r...

journal_title：Cellular and molecular neurobiology

authors： Chen C,Hu Y,Dong XZ,Zhou XJ,Mu LH,Liu P

更新日期：2018-07-01 00:00:00

abstract：:1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. ...

journal_title：Cellular and molecular neurobiology

authors： Chiu R,Rey O,Zheng JQ,Twiss JL,Song J,Pang S,Yokoyama KK

更新日期：2003-12-01 00:00:00

abstract：:1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neu...

journal_title：Cellular and molecular neurobiology

authors： Hughes TK,Cadet P,Rady PL,Tyring SK,Chin R,Smith EM

更新日期：1994-02-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00

abstract：:Cathepsin K deficiency in male mice (Ctsk-/-) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because T...

journal_title：Cellular and molecular neurobiology

authors： Dauth S,Rakov H,Sîrbulescu RF,Ilieş I,Weber J,Batbajar Dugershaw B,Braun D,Rehders M,Wirth EK,Führer D,Schweizer U,Brix K

更新日期：2020-07-01 00:00:00

abstract：:1. The effect of lead (in vivo) on the uptake of GABA, dopamine, and histidine as a precursor of histamine in synaptosomes obtained from chronically lead-treated rats was studied. 2. Lead decreased the uptake of GABA, increased the uptake of dopamine, and did not change the uptake of histidine. These effects were inde...

journal_title：Cellular and molecular neurobiology

authors： Jabłońska L,Walski M,Rafałowska U

更新日期：1994-12-01 00:00:00

abstract：:In rats, variations in the levels of neuromodulatory molecules and in the expression of their receptors are observed during pregnancy and postpartum. These changes may contribute to the development and management of maternal behavior. The frequency of licking the pups is used to evaluate maternal care, having mothers ...

journal_title：Cellular and molecular neurobiology

authors： de Moura AC,da Silva IR,Reinaldo G,Dani C,Elsner VR,Giovenardi M

更新日期：2016-10-01 00:00:00

abstract：:Overexpression of suppressor of cytokine signalling 2 (SOCS2) has been shown to promote hippocampal neurogenesis in vivo and promote neurite outgrowth of neurons in vitro. In the adult mouse brain, SOCS2 is most highly expressed in the hippocampal CA3 region and at lower levels in the dentate gyrus, an expression patt...

journal_title：Cellular and molecular neurobiology

authors： Basrai HS,Turbic A,Christie KJ,Turnley AM

更新日期：2017-07-01 00:00:00

abstract：:1. The original concept of the ischemic penumbra surrounding a focus of dense cerebral ischemia is based on electrophysiological observations. In the cortex of baboons following middle cerebral artery occlusion, complete failure of the cortical evoked potential was observed at a cerebral blood flow (CBF) threshold lev...

journal_title：Cellular and molecular neurobiology

authors： Back T

更新日期：1998-12-01 00:00:00

abstract：:We aim to develop a cultured cell model, to serve as a system with which the altered circadian phenotypes produced by the clock gene variations could be studied in vitro. Tau mutation, which shortens the circadian period of hamsters and mice, was introduced into the CK1epsilon locus of cultured Rat1-R12 cells by gene ...

journal_title：Cellular and molecular neurobiology

authors： Shimada H,Numazawa K,Sasaki T,Kato N,Ebisawa T

更新日期：2009-07-01 00:00:00

abstract：:1. Wobbler mice suffer an autosomal recessive mutation producing severe motoneuron degeneration and dense astrogliosis, with increased levels of glial fibrillary acidic protein (GFAP) in the spinal cord and brain stem. They have been considered animal models of amyotrophic lateral sclerosis and infantile spinal muscul...

journal_title：Cellular and molecular neurobiology

authors： Gonzalez Deniselle MC,Gonzalez SL,Piroli GG,Lima AE,De Nicola AF

更新日期：1996-02-01 00:00:00

abstract：AIM:A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS:Electron microscop...

journal_title：Cellular and molecular neurobiology

authors： Sombers LA,Maxson MM,Ewing AG

更新日期：2007-08-01 00:00:00

abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

journal_title：Cellular and molecular neurobiology

authors： Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

更新日期：1998-06-01 00:00:00

abstract：:Symptoms like mental retardation, depression, and anxiety have been observed during aging. Almost similar phenotypes have been evident in patients having haploinsufficiency or mutations in Pax6, a transcriptional regulator. Since Pax6 regulates axon guidance, differentiation of neurons from glia, and neuronal migratio...

journal_title：Cellular and molecular neurobiology

authors： Tripathi R,Mishra R

更新日期：2012-03-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

journal_title：Cellular and molecular neurobiology

authors： Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

更新日期：2017-01-01 00:00:00

abstract：:1. We describe here the alterations in the nociceptive sensitivity of Swiss CD1 mice receiving an intraplantar (i.pl.) administration of XC Rous sarcoma-virus-transformed rat fibroblasts (XC cells). 2. Histological studies reveal that XC cells remain at the injection site 2-3 weeks after implantation, a time at which ...

journal_title：Cellular and molecular neurobiology

authors： Baamonde A,Lastra A,Fresno MF,Llames S,Meana A,Hidalgo A,Menéndez L

更新日期：2004-04-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)), a major reactive oxygen species produced during oxidative stress, has been implicated in the pathophysiology of various neurodegenerative conditions. Cyperus rotundus is a traditional medicinal herb that has recently found applications in food and confectionary industries. In the current ...

journal_title：Cellular and molecular neurobiology

authors： Kumar KH,Khanum F

更新日期：2013-01-01 00:00:00