Abstract：
:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly accumulate AChE while approaching the outer brain surface. 2. By exploiting AChE as a sensitive and early histochemical differentiation marker, we have demonstrated complex polycentric waves of differentiation spreading upon the cranial part of the chicken neural tube but a smooth rostrocaudal wave along the spinal cord. Shortly after expression of AChE, these cells extend long projecting neurites. In particular, segmented spinal motor axons originate from AChE-positive motoneurones; they navigate through a BChE-active zone within the rostral half of the sclerotomes before contacting BChE/AChE-positive myotome cells. At synaptogenetic stages, cholinesterases additionally are detectable in neurofibrillar laminae foreshadowing the establishment of cholinergic synapses. 3. In order to elucidate the functional significance of cholinesterases at early stages, we have investigated specific cholinesterase molecules and their mechanisms of action in vivo and in vitro. A developmental shift from the low molecular weight forms to the tetramers of both enzymes has been determined. In vitro, the addition of a selective BChE inhibitor leads to a reduction of AChE gene expression. Thus, in vivo and in vitro data suggest roles of cholinesterases in the regulation of cell proliferation and neurite growth. 4. Future research has to show whether neurogenetic functioning of cholinesterases can help to understand their reported alterations in neural tube defects, mental retardations, dementias and in some tumours.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Layer PGdoi
10.1007/BF00712798subject
Has Abstractpub_date
1991-02-01 00:00:00pages
7-33issue
1eissn
0272-4340issn
1573-6830journal_volume
11pub_type
杂志文章,评审abstract：:1. Studies conducted on the rat arcuate nucleus, an area involved in the development and control of LH and FSH secretion, have shown the existence of hormonally regulated developmental sex differences in synaptic patterns and estrogen-induced synaptic plasticity during adult life. Several questions raised by these fin...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02088177
更新日期：1996-04-01 00:00:00
abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-018-00647-3
更新日期：2019-03-01 00:00:00
abstract：:1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field te...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1006984402291
更新日期：1999-10-01 00:00:00
abstract：:To clarify the role of angiotensin II (Ang II) in the regulation of sensory signaling, we studied the effect of subpressor dose (150 ng/kg/min) of Ang II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) after chronic constriction...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-9934-7
更新日期：2013-07-01 00:00:00
abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-011-9748-4
更新日期：2012-03-01 00:00:00
abstract：:Transient forebrain ischemia and reperfusion induces delayed neuronal death (DND) in the hippocampal Cornu Ammonis 1 (CA1) subfield of stroke-prone spontaneously hypertensive rat (SHRSP). The vulnerability to DND is potentially related to the genetic susceptibility to stroke in this strain. To elucidate the mechanism ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9347-9
更新日期：2009-06-01 00:00:00
abstract：:Cerebral hemorrhage is a series of devastating cerebrovascular diseases with high mortality, morbidity and recurrence rate. Localized and systemic immuno-reactions are involved. Aggregation of immunocytes, which were both recruited from the peripheral circulation and resident in the central nervous system, is induced ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s10571-018-0601-x
更新日期：2018-10-01 00:00:00
abstract：:The effects of the divalent cations Ca and Mg on the properties of ACh-activated channels at the frog neuromuscular junction were studied using a two-microelectrode voltage clamp. The divalent cation concentration was varied from 2 to 40 mM in solutions containing 50% normal Na. The reversal potential was determined b...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00733590
更新日期：1984-09-01 00:00:00
abstract：:ATP13A4 is a member of the subfamily of P5-type ATPases. P5-type ATPases are the least studied of the P-type ATPase subfamilies with no ion specificities assigned to them. In order to elucidate ATP13A4 function, we studied the protein's subcellular localization and tested whether it is involved in calcium regulation. ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9445-8
更新日期：2010-03-01 00:00:00
abstract：:We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion m...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-9939-2
更新日期：2013-07-01 00:00:00
abstract：:Agmatine is an endogenous amine that is synthesized following the decarboxylation of L-arginine by arginine decarboxylase. Agmatine exists in mammalian brain and has been proposed as a neurotransmitter and/or neurotransmodulator. Agmatine binds to several targets and is considered as an endogenous ligand for imidazoli...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s10571-007-9164-y
更新日期：2008-08-01 00:00:00
abstract：:Glycoproteins of the extracellular matrix (ECM) regulate proliferation, migration, and differentiation in numerous cell lineages. ECM functions are initiated by small peptide sequences embedded in large constituents that are recognized by specific cellular receptors. In this study, we have investigated the biological ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-015-0170-1
更新日期：2015-07-01 00:00:00
abstract：:1. Antidepressants have been used clinically for many years; however, the neurochemical mechanism for their therapeutic effect has not been clarified yet. Recent reports indicate that chronic antidepressant treatment directly affects the postsynaptic membrane to increase the coupling between the stimulatory GTP-bindin...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1006972709733
更新日期：1999-02-01 00:00:00
abstract：:The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to reduce stress responses. Acute restraint stress (ARS) is a stress mo...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-017-0518-9
更新日期：2018-01-01 00:00:00
abstract：:1. 3H-gamma-Aminobutyric acid (GABA) release elicited by a depolarizing K+ stimulus or by noradrenergic transmitter was examined in rat pineals in vitro. 2. The release of 3H-GABA was detectable at a 20 mM K+ concentration in medium and increased steadily up to 80 mM K+. 3. In a Ca2+-free medium 3H-GABA release elicit...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00713029
更新日期：1989-06-01 00:00:00
abstract：AIM:A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS:Electron microscop...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-007-9156-y
更新日期：2007-08-01 00:00:00
abstract：:Early-life experiences have been linked to individual's epigenetic status and social behaviour. Therefore, the present study aims to test whether the presence of mother suppress the early-life stressful social experience (SSE)-induced effect on social behaviour of adolescent and adult rats, and associated epigenetic c...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-019-00655-x
更新日期：2019-04-01 00:00:00
abstract：:1. Wobbler mice suffer an autosomal recessive mutation producing severe motoneuron degeneration and dense astrogliosis, with increased levels of glial fibrillary acidic protein (GFAP) in the spinal cord and brain stem. They have been considered animal models of amyotrophic lateral sclerosis and infantile spinal muscul...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02578387
更新日期：1996-02-01 00:00:00
abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1023/a:1006991809927
更新日期：2000-02-01 00:00:00
abstract：:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-006-9115-z
更新日期：2007-02-01 00:00:00
abstract：:1. The electrophysiological actions of excitatory amino acids and serotonin were investigated in slices from cat neocortex in vitro. Intracellular recordings were obtained from neurons (mainly in layer V) and the drugs applied extracellularly to the same neurons by microiontophoresis. 2. Serotonin, and to some extent ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00733789
更新日期：1987-12-01 00:00:00
abstract：:Astragalosides (AST) are reported to be neuroprotective in focal cerebral ischemic models in vivo. In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding bac...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-014-0059-4
更新日期：2014-08-01 00:00:00
abstract：:P2X3 receptor expression in various tissues appears to be modulated by age. In the present study, we used single cell RT-PCR to determine the number of P2X3 positive myenteric neurons at different stages of guinea pig postnatal development, and we tested if similar changes also occur to other myenteric P2X receptors. ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-014-0055-8
更新日期：2014-07-01 00:00:00
abstract：:Green fluorescent protein (GFP) gene was transfected and expressed in murine embryonic stem (ES) cells under the control of the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter. Stably transfected cells were characterized by immunohistochemistry and by fluorescence microscopy. Cells containing GFP we...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1015397829913
更新日期：2002-02-01 00:00:00
abstract：:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1013823524302
更新日期：2001-10-01 00:00:00
abstract：:Spinal cord libraries subtracted against visual cortex using suppression subtractive hybridization SSH are dominated by abundant gene sequences derived from myelin elements. We compared our subtracted library results of three of these abundant sequences to published expressed sequence tag libraries that are not normal...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9408-0
更新日期：2009-12-01 00:00:00
abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-011-9739-5
更新日期：2012-01-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-015-0323-2
更新日期：2016-11-01 00:00:00
abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02073327
更新日期：1995-04-01 00:00:00
abstract：:1. The analogies between the processing of amyloid precursor protein (APP) and other transmembrane sterol regulatory element binding proteins (SREBPs) inspired us to conduct further studies on whether beta-amyloid (Abeta) affects aromatase by interacting with APP and SREBP. 2. In this study, cultured human neuroblasto...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-006-9060-x
更新日期：2006-05-01 00:00:00
