Coexisting peptides in hypothalamic neuroendocrine systems: some functional implications.


:1. Coexisting with oxytocin or vasopressin in the cell bodies and nerve terminals of the hypothalamic-neurohypophysial system are smaller amounts of other peptides. For a number of these "copeptides" there is strong evidence of corelease with the major magnocellular hormones. Guided by the location of their specific receptors we have studied the effects of three copeptides, dynorphin, cholecystokinin (CCK), and corticotropin releasing hormone (CRH), on the secretion of oxytocin and vasopressin from isolated rat neural lobe or neurointermediate lobe preparations in vitro. 2. Dynorphin is coreleased with vasopressin from neural lobe nerve terminals and acts on neural lobe kappa-opiate receptors to inhibit the electrically stimulated secretion of oxytocin. Naloxone augments oxytocin release from the neural lobe in a manner directly proportional to the amount of vasopressin (and presumably dynorphin) released. 3. Cholecystokinin, coreleased with oxytocin by neural lobe terminals, has been shown to have high-affinity receptors located in the NL and to stimulate secretion of both oxytocin and vasopressin. CCK's secretagogue effect was independent of electrical stimulation and extracellular Ca2+ and was blocked by an inhibitor of protein kinase C. 4. CRH, coreleased with OT from the neural lobe, has receptors in the intermediate lobe of the pituitary, but not in the neural lobe itself. CRH stimulates the secretion of oxytocin and vasopressin from combined neurointermediate lobes but not from isolated neural lobes. Intermediate lobe peptides, alpha and gamma melanocyte stimulating hormone, induced secretion of oxytocin and vasopressin from isolated neural lobes. Their effect was, like that of CCK, independent of electrical stimulation and extracellular Ca2+ and blocked by an inhibitor of protein kinase C. 5. Among the CRH-producing parvocellular neurons of the paraventricular nucleus, in the normal rat, approximately half also produce and store vasopressin. After removal of glucocorticoid influence by adrenalectomy, virtually all of the CRH neurons contain vasopressin. 6. The two subtypes of CRH neurosecretory cells found in the normal rat possess different topographical distributions in the paraventricular nucleus, suggesting the possibility of differential innervation. Stress selectively activates the vasopressin containing subpopulation of CRH neurons, indicating that there are separate channels of regulatory input controlling the two components of the parvocellular CRH neurosecretory system.


Cell Mol Neurobiol


Bondy CA,Whitnall MH,Brady LS,Gainer H




Has Abstract


1989-12-01 00:00:00












  • Alteration of calcium conductances and outward current by cyclic adenosine monophosphate (cAMP) in neurons of Limax maximus.

    abstract::Membrane responses to cyclic adenosine monophosphate (cAMP) injections have been studied by means of voltage clamp, Ca-indicator dye, and ion substitution techniques in identified neurons from the abdominal ganglion of Limax maximus. The ventral abdominal giant cell (AGC) displayed a response consisting of a decrease ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Hockberger P,Connor JA

    更新日期:1984-12-01 00:00:00

  • Intrinsic regulation of brain inflammatory responses.

    abstract::It is now well accepted that inflammatory responses in brain contribute to the genesis and evolution of damage in neurological diseases, trauma, and infection. Inflammatory mediators including cytokines, cell adhesion molecules, and reactive oxygen species including NO are detected in human brain and its animal models...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Galea E,Heneka MT,Dello Russo C,Feinstein DL

    更新日期:2003-10-01 00:00:00

  • Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation.

    abstract::Naked2 (NKD2), one member of Naked family, has been shown to negatively regulate Wnt/β-catenin signaling pathway. It has been recognized that NKD2 plays a vital role in cell homeostasis and prevention of tumorigenesis. However, NKD2 expression and its functional role in the brain in neuroinflammatory processes remain ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Cui Z,Zhou L,Song Y,Liu C,Zhu G,Wu X,Yan Y,Xia X,Duan C,Zhou Y,Huang Y,Zhang D

    更新日期:2016-01-01 00:00:00

  • Steroids in Stroke with Special Reference to Progesterone.

    abstract::Both sex and steroid hormones are important to consider in human ischemic stroke and its experimental models. Stroke initiates a cascade of changes that lead to neural cell death, but also activates endogenous protective processes that counter the deleterious consequences of ischemia. Steroids may be part of these cer...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Guennoun R,Zhu X,Fréchou M,Gaignard P,Slama A,Liere P,Schumacher M

    更新日期:2019-05-01 00:00:00

  • Altering cellular signaling pathways enhance gene silencing activity of shRNA, shRNA.ribozyme, and shRNA.antisense in neuroblastoma cells.

    abstract::1. RNA interference (RNAi) is a multicomponent machinery that operates in a sequence-specific manner to repress the expression of genes in most eukaryotic cells. 2. Here we wanted to investigate in a murine neuroblastoma cell line (NBP2) (a) if replacement of the loop of the short hairpin RNA (shRNA) with a hammerhead...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Nahreini P,Hanson AJ,Andreatta CP,Koustas WT,Prasad KN

    更新日期:2004-12-01 00:00:00

  • Role of normalization in the elimination of abundant myelin sequences in spinal cord cDNA libraries produced by suppression subtractive hybridization.

    abstract::Spinal cord libraries subtracted against visual cortex using suppression subtractive hybridization SSH are dominated by abundant gene sequences derived from myelin elements. We compared our subtracted library results of three of these abundant sequences to published expressed sequence tag libraries that are not normal...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Lathia KB,Yan Z,Clapshaw PA

    更新日期:2009-12-01 00:00:00

  • Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents.

    abstract::1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Platt B,Büsselberg D

    更新日期:1994-12-01 00:00:00

  • Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat.

    abstract:AIM:Poly (ADP-ribose) polymerase (PARP) is a nuclear repair enzyme whose role is widely depicted in various physiological and pathological processes. In the present study, we wanted to check the status of PARP and the role of various cell death proteases involved in apoptotic and non-apoptotic forms of cell death durin...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Chaitanya GV,Babu PP

    更新日期:2009-06-01 00:00:00

  • Correction to: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1.

    abstract::The original version of this article unfortunately contained a typo in co-author name. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 已发布勘误


    authors: Narayan A,Hunkele A,Xu J,Bassoni DL,Pasternak GW,Pan YX

    更新日期:2020-10-31 00:00:00

  • Identification of a 7B2-derived tridecapeptide from bovine adrenal medulla chromaffin vesicles.

    abstract::1. A novel tridecapeptide was isolated from extracts of bovine adrenal medulla chromaffin vesicles and the primary structure determined to be SVPHFSDEDKDPE. 2. This peptide is identical to the C termini of human and porcine 7B2 and is highly homologous to the same region of the mouse and Xenopus lavis protein. 3. In a...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Sigafoos J,Chestnut WG,Merrill BM,Taylor LC,Diliberto EJ Jr,Viveros OH

    更新日期:1993-06-01 00:00:00

  • Light-Induced Retinal Ganglion Cell Damage and the Relevant Mechanisms.

    abstract::While light is the basic element for inducing vision and modulating circadian rhythms, excessive light has been reported to have a negative effect on the survival of various types of retinal cells. Among them photoreceptors and retinal pigment epithelial (RPE) cells degeneration after light exposure is widely observed...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Zhao Y,Shen Y

    更新日期:2020-11-01 00:00:00

  • The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons.

    abstract::We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Xiang H,Tao W,Wang L,Wang F,Xu A

    更新日期:2008-12-01 00:00:00

  • Quantitative analysis of delayed neuronal death in the hippocampal subfields of SHRSP and SHR.

    abstract::Transient forebrain ischemia and reperfusion induces delayed neuronal death (DND) in the hippocampal Cornu Ammonis 1 (CA1) subfield of stroke-prone spontaneously hypertensive rat (SHRSP). The vulnerability to DND is potentially related to the genetic susceptibility to stroke in this strain. To elucidate the mechanism ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Daisu M,Hatta T,Sakurai-Yamashita Y,Nabika T,Moritake K

    更新日期:2009-06-01 00:00:00

  • Alpha2-adrenergic impact on hypothalamic magnocellular oxytocinergic neurons in long evans and brattleboro rats: effects of agonist and antagonists.

    abstract::We have previously demonstrated that alpha2-adrenoceptors regulate hypothalamic magnocellular oxytocinergic (OXY) neurons in Sprague Dawley rats. Here we investigated whether activation/inhibition of alpha2-adrenoceptors may similarly trigger/downregulate the activity of OXY neurons in control Long Evans (+/+) and per...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

    更新日期:2009-09-01 00:00:00

  • Effect of ionophores on the processing of the beta-amyloid precursor protein in different cell lines.

    abstract::1. Alzheimer's disease is characterized by the deposition in the brain of extracellular amyloid plaques and vascular deposits consisting mostly of amyloid beta-peptide (A beta). A beta, a polypeptide of 39-43 amino acids (M(r), approximately 4 kDa), is derived proteolytically from a family of proteins of 695-770 amino...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Lahiri DK

    更新日期:1994-08-01 00:00:00

  • The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro.

    abstract::1. The electrophysiological actions of excitatory amino acids and serotonin were investigated in slices from cat neocortex in vitro. Intracellular recordings were obtained from neurons (mainly in layer V) and the drugs applied extracellularly to the same neurons by microiontophoresis. 2. Serotonin, and to some extent ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Nedergaard S,Engberg I,Flatman JA

    更新日期:1987-12-01 00:00:00

  • Effect of ventral noradrenergic bundle lesions on concentrations of monoamine neurotransmitters and metabolites in several discrete areas of the rat brain.

    abstract::1. The effects of radiofrequency lesions of the ventral noradrenergic bundle (VNB) on monoamine and metabolite concentrations in several discrete areas of the rat hypothalamus were examined. Monoamines and metabolites were analyzed utilizing high-performance liquid chromatography coupled with electrochemical detection...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Johnston CA,Mattiace LA,Negro-Vilar A

    更新日期:1987-12-01 00:00:00

  • Rab10 Disruption Results in Delayed OPC Maturation.

    abstract::Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice prov...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Zhang ZH,Zhao WQ,Ma FF,Zhang H,Xu XH

    更新日期:2017-10-01 00:00:00

  • Standardised extract of Bacopa monniera (CDRI-08) improves contextual fear memory by differentially regulating the activity of histone acetylation and protein phosphatases (PP1α, PP2A) in hippocampus.

    abstract::Contextual fear conditioning is a paradigm for investigating cellular mechanisms involved in hippocampus-dependent memory. Earlier, we showed that standardised extract of Bacopa monniera (CDRI-08) improves hippocampus-dependent learning in postnatal rats by elevating the level of serotonin (5-hydroxytryptamine, 5-HT),...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Preethi J,Singh HK,Venkataraman JS,Rajan KE

    更新日期:2014-05-01 00:00:00

  • The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1.

    abstract::Glioblastoma is the most malignant primary brain tumor and is very resistant to treatment; hence, it has a poor prognosis. Neurotensin receptor type 1 (NTSR1) plays a key role in cancer malignancy and has potential therapeutic applications. However, the presence and function of neurotensin (NTS) receptors in glioblast...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Ayala-Sarmiento AE,Martinez-Fong D,Segovia J

    更新日期:2015-08-01 00:00:00

  • Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway.

    abstract::Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight junction morphological changes induced by ischemia stroke. Thus, in the current study,...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Lv Y,Liu W,Ruan Z,Xu Z,Fu L

    更新日期:2019-03-01 00:00:00

  • PARK2 and PARK7 Gene Polymorphisms as Risk Factors Associated with Serum Element Concentrations and Clinical Symptoms of Parkinson's Disease.

    abstract::Besides clinical and imaging techniques, there is a lack of molecular makers for the diagnosis of Parkinson's disease (PD). There is an immense need to develop biomarkers associated with the phenotypes which may be valuable for individualized treatment. Single-nucleotide polymorphisms (PARK2: Ser167Asn (G>A) and Val38...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Sanyal J,Anirudhan A,Banerjee TK,Guha G,Ramakrishnan Veerabathiran,Murugesan R,Ahmed SSJS,Rao VR

    更新日期:2020-04-01 00:00:00

  • RhoC involved in the migration of neural stem/progenitor cells.

    abstract::Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

    更新日期:2014-04-01 00:00:00

  • Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing.

    abstract::Glioblastoma Multiforme (GBM) is an aggressive form of brain Tumor that has few cures. In this study, we analyze the anti-proliferative effects of a new molecule JQ1 against GBMs induced in Wistar Rats. JQ1 is essentially a Myc inhibitor. c-Myc is also known for altering the biochemistry of a tumor cell. Therefore, th...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Rajagopalan V,Vaidyanathan M,Janardhanam VA,Bradner JE

    更新日期:2014-10-01 00:00:00

  • Morphological characteristics of different types of neurons in the ventrooralis anterior, ventrooralis internus, and ventrooralis posterior nuclei in the human thalamus.

    abstract::1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: al-Hussain SM

    更新日期:1992-06-01 00:00:00

  • Hydroalcoholic extract of cyperus rotundus ameliorates H2O2-induced human neuronal cell damage via its anti-oxidative and anti-apoptotic machinery.

    abstract::Hydrogen peroxide (H(2)O(2)), a major reactive oxygen species produced during oxidative stress, has been implicated in the pathophysiology of various neurodegenerative conditions. Cyperus rotundus is a traditional medicinal herb that has recently found applications in food and confectionary industries. In the current ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Kumar KH,Khanum F

    更新日期:2013-01-01 00:00:00

  • Effect of Induction Time on the Proliferation and Differentiation of Induced Schwann-Like Cells from Adipose-Derived Stem Cells.

    abstract::To compare how different induction time takes effect on the proliferation and secretion ability of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs), ADSCs were isolated from healthy adult female rats. Flow cytometry (FCM) was performed to detect the ADSC-positive markers CD29, CD44, and CD90 and the ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Wong CW,Xu Y,Liu X,Xu S,Zhang Y,Zhu Z,He B

    更新日期:2020-10-01 00:00:00

  • Prenatal hormones organize sex differences of the neuroendocrine reproductive system: observations on guinea pigs and nonhuman primates.

    abstract::1. The central nervous systems (CNS) of males and females differ in the control mechanisms for the release of gonadotropins from the anterior pituitary gland as well as the capacity to display sex specific behaviors. 2. In guinea pigs and monkeys, these differences are organized through the actions of prenatal androge...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Resko JA,Roselli CE

    更新日期:1997-12-01 00:00:00

  • A study of the distribution and density of the VEGFR-2 receptor on glioma microvascular endothelial cell membranes.

    abstract::The purpose of the study was to examine the nanoscale distribution and density of the VEGFR-2 membrane receptor on the endothelial cell surface of glioma microvasculature. Immunofluorescence and atomic force microscopy combined with immunogold labeling techniques were used to characterize and determine the position of...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Zhou D,Zhan S,Zhou D,Li Z,Lin X,Tang K,Shu H,Chen G,Zeng S,Cai Y,Jiang X

    更新日期:2011-07-01 00:00:00

  • Homocysteine induces hypophosphorylation of intermediate filaments and reorganization of actin cytoskeleton in C6 glioma cells.

    abstract::In this study, we investigated the actions of high homocysteine (Hcy) levels (100 and 500 microM) on the cytoskeleton of C6 glioma cells. Results showed that the predominant cytoskeletal response was massive formation of actin-containing filopodia at the cell surface that could be related with Cdc42 activation and inc...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章


    authors: Loureiro SO,Heimfarth L,Lacerda BA,Vidal LF,Soska A,dos Santos NG,de Souza Wyse AT,Pessoa-Pureur R

    更新日期:2010-05-01 00:00:00