Inflammatory cytokines in diabetic nephropathy.

abstract：Aim:To evaluate the effect of an inhibitor of sodium-glucose cotransporter 2 (SGLT-2 inhibitor, dapagliflozin) on glycemic variability in type 2 diabetes mellitus (T2D) under insulin glargine combined with oral hypoglycemic drugs, using a continuous glucose monitoring system (CGMS). Methods:This prospective, self-cont...

journal_title：Journal of diabetes research

authors： Luo M,Kong X,Wang H,Zhai X,Cai T,Ding B,Hu Y,Jing T,Su X,Li H,Ma J

更新日期：2020-11-24 00:00:00

abstract：:Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

journal_title：Journal of diabetes research

authors： Aravindhan V,Madhumitha H

更新日期：2016-01-01 00:00:00

abstract：Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...

journal_title：Journal of diabetes research

authors： Li HF,Cai L,Golden AR

更新日期：2019-08-01 00:00:00

abstract：:The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...

journal_title：Journal of diabetes research

authors： Au DT,Strickland DK,Muratoglu SC

更新日期：2017-01-01 00:00:00

abstract：:Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic gro...

journal_title：Journal of diabetes research

authors： Wang P,Liu H,Chen L,Duan Y,Chen Q,Xi S

更新日期：2017-01-01 00:00:00

abstract：:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...

journal_title：Journal of diabetes research

authors： Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji L

更新日期：2018-08-01 00:00:00

abstract：:Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, sing...

journal_title：Journal of diabetes research

authors： Al-Saber F,Aldosari W,Alselaiti M,Khalfan H,Kaladari A,Khan G,Harb G,Rehani R,Kudo S,Koda A,Tanaka T,Nakajima M,Darwish A

更新日期：2016-01-01 00:00:00

abstract：:We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...

journal_title：Journal of diabetes research

authors： Fotiou P,Raptis A,Apergis G,Dimitriadis G,Vergados I,Theodossiadis P

更新日期：2014-01-01 00:00:00

abstract：:This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...

journal_title：Journal of diabetes research

authors： Wang Z,Shen XH,Feng WM,Ye GF,Qiu W,Li B

更新日期：2016-01-01 00:00:00

abstract：:Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...

journal_title：Journal of diabetes research

authors： Ratanawongsa N,Chan LL,Fouts MM,Murphy EJ

更新日期：2017-01-01 00:00:00

abstract：:Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is uncertain which pathway has the most implication on the disease. Changes in the expression of an entire pathway might be more important for disease pathogenesis than changes in the expression of individual genes. To ident...

journal_title：Journal of diabetes research

authors： Taneera J,Storm P,Groop L

更新日期：2014-01-01 00:00:00

abstract：Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in ...

journal_title：Journal of diabetes research

authors： Liu Z,Chen Y,Chen G,Mao X,Wei X,Li X,Xu Y,Jiang F,Wang K,Liu C

更新日期：2019-02-21 00:00:00

abstract：:Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases an...

journal_title：Journal of diabetes research

authors： Ma ZJ,Chen R,Ren HZ,Guo X,Guo J,Chen LM

更新日期：2014-01-01 00:00:00

abstract：:The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...

journal_title：Journal of diabetes research

authors： Bertinat R,Westermeier F,Silva P,Gatica R,Oliveira JM,Nualart F,Gomis R,Yáñez AJ

更新日期：2018-05-29 00:00:00

abstract：:Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...

journal_title：Journal of diabetes research

authors： Zhang H,Zhao T,Li Z,Yan M,Zhao H,Zhu B,Li P

更新日期：2017-01-01 00:00:00

abstract：:Knowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective managemen...

journal_title：Journal of diabetes research

authors： Zhao Y,Xing H

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...

journal_title：Journal of diabetes research

authors： Yerlikaya G,Falcone V,Stopp T,Mittlböck M,Tura A,Husslein P,Eppel W,Göbl CS

更新日期：2018-05-08 00:00:00

abstract：:Background. The aim of this study was to validate the impact of type 2 diabetes (T2D) on the platelet reactivity in patients with acute ST elevation myocardial infarction (STEMI) treated with adenosine diphosphate (ADP) receptor blockers. Methods. A pilot prospective study was performed. Totally 67 patients were enrol...

journal_title：Journal of diabetes research

authors： Samoš M,Fedor M,Kovář F,Galajda P,Bolek T,Stančiaková L,Fedorová J,Staško J,Kubisz P,Mokáň M

更新日期：2016-01-01 00:00:00

abstract：Background:The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patien...

journal_title：Journal of diabetes research

authors： Khalili S,Sabaghian T,Sedaghat M,Soroureddin Z,Askari E,Khalili N

更新日期：2021-01-06 00:00:00

abstract：:Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...

journal_title：Journal of diabetes research

authors： Jamiołkowska M,Jamiołkowska I,Łuczyński W,Tołwińska J,Bossowski A,Głowińska Olszewska B

更新日期：2016-01-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...

journal_title：Journal of diabetes research

authors： Feng S,Yu H,Yu Y,Geng Y,Li D,Yang C,Lv Q,Lu L,Liu T,Li G,Yuan L

更新日期：2018-04-04 00:00:00

abstract：:According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...

journal_title：Journal of diabetes research

authors： Arroyo-Carmona RE,López-Serrano AL,Albarado-Ibañez A,Mendoza-Lucero FM,Medel-Cajica D,López-Mayorga RM,Torres-Jácome J

更新日期：2016-01-01 00:00:00

abstract：AIM:To evaluate an agreement in identifying dysglycemia between fasting plasma glucose (FPG) and the 2 hr postprandial glucose tolerance test (OGTT) in a population with high risk of diabetes. METHODS:A total of 6,884 individuals aged 35-65 years recruited for a community-based diabetes prevention program were tested ...

journal_title：Journal of diabetes research

authors： Aekplakorn W,Tantayotai V,Numsangkul S,Sripho W,Tatsato N,Burapasiriwat T,Pipatsart R,Sansom P,Luckanajantachote P,Chawarokorn P,Thanonghan A,Lakhamkaew W,Mungkung A,Boonkean R,Chantapoon C,Kungsri M,Luanseng K,Chaiyaji

更新日期：2015-01-01 00:00:00

abstract：:To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...

journal_title：Journal of diabetes research

authors： Hu JF,Zhang GJ,Wang L,Kang PF,Li J,Wang HJ,Gao Q,Chen YQ

更新日期：2014-01-01 00:00:00

abstract：:Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...

journal_title：Journal of diabetes research

authors： Ortiz-Avila O,Esquivel-Martínez M,Olmos-Orizaba BE,Saavedra-Molina A,Rodriguez-Orozco AR,Cortés-Rojo C

更新日期：2015-01-01 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...

journal_title：Journal of diabetes research

authors： Schacht S,Masood F,Catmull S,Dolan R,Altabtabaee R,Grow W,Al-Nakkash L

更新日期：2017-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and in...

journal_title：Journal of diabetes research

authors： Tanase DM,Gosav EM,Costea CF,Ciocoiu M,Lacatusu CM,Maranduca MA,Ouatu A,Floria M

更新日期：2020-07-31 00:00:00

abstract：AIMS AND BACKGROUND:Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage. In this study, we explore the possibility of treating the disease with a novel combination approach of oleanolic acid (OA), a glycogen ph...

journal_title：Journal of diabetes research

authors： Wang X,Chen Y,Abdelkader D,Hassan W,Sun H,Liu J

更新日期：2015-01-01 00:00:00

abstract：:Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...

journal_title：Journal of diabetes research

authors： Watanabe A,Noguchi H,Oe M,Sanada H,Mori T

更新日期：2017-01-01 00:00:00