Abstract:
:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose concentrations at 0 (G0), 60 (G60), and 120 min (G120) were collected. OGTT glucose levels were significantly associated with the later requirement of pharmacotherapy (ROC-AUC: 71.1, 95% CI: 63.8-78.3). Also, the combination of clinical risk factors (age, BMI, parity, and pharmacotherapy in previous gestation) showed an acceptable predictive accuracy (ROC-AUC: 72.1, 95% CI: 65.0-79.2), which was further improved when glycemic parameters were added (ROC-AUC: 77.5, 95% CI: 71.5-83.9). Random forest analysis revealed the highest variable importance for G0, G60, and age. OGTT glucose measures in addition to clinical risk factors showed promising properties for risk stratification in GDM patients classified by the recently established IADPSG criteria.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Yerlikaya G,Falcone V,Stopp T,Mittlböck M,Tura A,Husslein P,Eppel W,Göbl CSdoi
10.1155/2018/3243754subject
Has Abstractpub_date
2018-05-08 00:00:00pages
3243754eissn
2314-6745issn
2314-6753journal_volume
2018pub_type
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pub_type: 杂志文章,随机对照试验
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abstract::The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2909436
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-28 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1756798
更新日期:2019-10-28 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2018-05-20 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2018/6093595
更新日期:2018-02-26 00:00:00