Abstract:
:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Tanase DM,Gosav EM,Costea CF,Ciocoiu M,Lacatusu CM,Maranduca MA,Ouatu A,Floria Mdoi
10.1155/2020/3920196subject
Has Abstractpub_date
2020-07-31 00:00:00pages
3920196eissn
2314-6745issn
2314-6753journal_volume
2020pub_type
杂志文章,评审abstract::Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. A...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/2879249
更新日期:2017-01-01 00:00:00
abstract::Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptoz...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7053963
更新日期:2016-01-01 00:00:00
abstract:Background:Diabetes mellitus is a widely diffused chronic condition which impacts on several aspects of patients' lives. In the current clinical practice, the implementation in the clinical routine of monitoring systems of patients' outcomes has led to an increased generation and use of several measures for the assessm...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/5419298
更新日期:2020-05-20 00:00:00
abstract::Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/2868652
更新日期:2016-01-01 00:00:00
abstract:AIM:To evaluate an agreement in identifying dysglycemia between fasting plasma glucose (FPG) and the 2 hr postprandial glucose tolerance test (OGTT) in a population with high risk of diabetes. METHODS:A total of 6,884 individuals aged 35-65 years recruited for a community-based diabetes prevention program were tested ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/396505
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major. However, this led to an increased risk of developing impaired glucose tolerance or diabetes. In this study we analyzed variables associated with the occurrence of impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1401829
更新日期:2016-01-01 00:00:00
abstract::Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2641248
更新日期:2016-01-01 00:00:00
abstract::A growing body of evidence suggests yogic practices may benefit adults with type 2 diabetes (DM2). In this systematic review, we evaluate available evidence from prospective controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management. To identify qualifying st...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6979370
更新日期:2016-01-01 00:00:00
abstract:Background:Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study is aimed at assessing the relationship between perirenal fat ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6076145
更新日期:2020-06-28 00:00:00
abstract::Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/351601
更新日期:2015-01-01 00:00:00
abstract::Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9286303
更新日期:2016-01-01 00:00:00
abstract:AIMS AND BACKGROUND:Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage. In this study, we explore the possibility of treating the disease with a novel combination approach of oleanolic acid (OA), a glycogen ph...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/973287
更新日期:2015-01-01 00:00:00
abstract::Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/961732
更新日期:2014-01-01 00:00:00
abstract::Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7319047
更新日期:2016-01-01 00:00:00
abstract::Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/613860
更新日期:2015-01-01 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1867059
更新日期:2016-01-01 00:00:00
abstract:Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8623560
更新日期:2018-03-20 00:00:00
abstract::Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6264149
更新日期:2016-01-01 00:00:00
abstract::South Asians have high prevalence of diabetes, cardiovascular risk, and physical inactivity. Reasons for physical inactivity have not been explored among Asians living within their endogenous environments. During phase 1 of the study, we assessed the physical activity (PA) of the population using a quantitative, descr...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/4319604
更新日期:2018-03-06 00:00:00
abstract::We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3201534
更新日期:2016-01-01 00:00:00
abstract:Background:Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. Aim:To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial ve...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/3159798
更新日期:2017-01-01 00:00:00
abstract::The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/4270301
更新日期:2016-01-01 00:00:00
abstract::To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8503754
更新日期:2017-01-01 00:00:00
abstract::We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
abstract:AIMS:Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS:Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/972431
更新日期:2014-01-01 00:00:00
abstract::Exercise is a cornerstone therapy for chronic diseases related to multiorgan insulin resistance. However, not all individuals show the anticipated improvement in insulin sensitivity following exercise and these individuals are considered exercise resistant. Caloric restriction is an approach to enhance the effect of e...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8314852
更新日期:2017-01-01 00:00:00
abstract::The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4989847
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of onsite screening with a nonmydriatic, digital fundus camera for diabetic retinopathy (DR) at a diabetes outpatient clinic. RESEARCH DESIGN AND METHODS:This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for mic...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4101890
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. The medical records of 21 type 2 diabetic patients who used a SGLT2i and 71 patients with sulfonylurea (control) were reviewed...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6807219
更新日期:2018-12-05 00:00:00