Impact of Real-Time Continuous Glucose Monitoring Use on Glucose Variability and Endothelial Function in Adolescents with Type 1 Diabetes: New Technology--New Possibility to Decrease Cardiovascular Risk?

abstract：Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...

journal_title：Journal of diabetes research

authors： Wang C,Hou XX,Rui HL,Li LJ,Zhao J,Yang M,Sun LJ,Dong HR,Cheng H,Chen YP

更新日期：2018-11-11 00:00:00

abstract：:Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...

journal_title：Journal of diabetes research

authors： Sha H,Zhao D,Tong X,Gregersen H,Zhao J

更新日期：2016-01-01 00:00:00

abstract：:More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...

journal_title：Journal of diabetes research

authors： da Silva Xavier G,Bellomo EA,McGinty JA,French PM,Rutter GA

更新日期：2013-01-01 00:00:00

abstract：:Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...

journal_title：Journal of diabetes research

authors： Watanabe A,Noguchi H,Oe M,Sanada H,Mori T

更新日期：2017-01-01 00:00:00

abstract：Objectives:Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs and to relate these levels to the variables of diabetes as well as...

journal_title：Journal of diabetes research

authors： Al-Nimer M,Ratha R,Mahwi T

更新日期：2019-11-16 00:00:00

abstract：Purpose:Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations....

journal_title：Journal of diabetes research

authors： Vlad CE,Foia L,Popescu R,Ivanov I,Luca MC,Delianu C,Toma V,Statescu C,Rezus C,Florea L

更新日期：2019-12-14 00:00:00

abstract：:It is understood that intrauterine hyperglycemia increases the risk of obesity and diabetes in offspring of consecutive generations but its mechanisms remain obscure. This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transg...

journal_title：Journal of diabetes research

authors： Zhang W,Su R,Feng H,Lin L,Wang C,Yang H

更新日期：2019-09-12 00:00:00

abstract：:The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...

journal_title：Journal of diabetes research

authors： Babaya N,Ueda H,Noso S,Hiromine Y,Nojima K,Itoi-Babaya M,Kobayashi M,Fujisawa T,Ikegami H

更新日期：2013-01-01 00:00:00

abstract：:Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...

journal_title：Journal of diabetes research

authors： Fontil V,McDermott K,Tieu L,Rios C,Gibson E,Sweet CC,Payne M,Lyles CR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...

journal_title：Journal of diabetes research

authors： Schacht S,Masood F,Catmull S,Dolan R,Altabtabaee R,Grow W,Al-Nakkash L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS:We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retino...

journal_title：Journal of diabetes research

authors： Alam U,Amjad Y,Chan AW,Asghar O,Petropoulos IN,Malik RA

更新日期：2016-01-01 00:00:00

abstract：Background:Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac fu...

journal_title：Journal of diabetes research

authors： Qiao S,Mao G,Li H,Ma Z,Hong L,Zhang H,Wang C,An J

更新日期：2018-07-17 00:00:00

abstract：:Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...

journal_title：Journal of diabetes research

authors： Afanasiev SA,Kondratieva DS,Rebrova TY,Batalov RE,Popov SV

更新日期：2016-01-01 00:00:00

abstract：:We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....

journal_title：Journal of diabetes research

authors： Gavan NA,Veresiu IA,Vinik EJ,Vinik AI,Florea B,Bondor CI

更新日期：2016-01-01 00:00:00

abstract：:The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...

journal_title：Journal of diabetes research

authors： Guan M,Li W,Xu L,Zeng Y,Wang D,Zheng Z,Lyv F,Xue Y

更新日期：2018-06-27 00:00:00

abstract：:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...

journal_title：Journal of diabetes research

authors： Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji L

更新日期：2018-08-01 00:00:00

abstract：:To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...

journal_title：Journal of diabetes research

authors： Hu JF,Zhang GJ,Wang L,Kang PF,Li J,Wang HJ,Gao Q,Chen YQ

更新日期：2014-01-01 00:00:00

abstract：Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...

journal_title：Journal of diabetes research

authors： Zhang J,Ma S,Wu S,Guo C,Long S,Tan H

更新日期：2019-09-05 00:00:00

abstract：AIMS:Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatina...

journal_title：Journal of diabetes research

authors： Papadopoulou-Marketou N,Margeli A,Papassotiriou I,Chrousos GP,Kanaka-Gantenbein C,Wahlberg J

更新日期：2017-01-01 00:00:00

abstract：Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...

journal_title：Journal of diabetes research

authors： Qiu S,Jia Y,Sun Y,Han P,Xu J,Wen G,Chai Y

更新日期：2019-02-17 00:00:00

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...

journal_title：Journal of diabetes research

authors： Gao Y,Wu X,Fu Q,Li Y,Yang T,Tang W

更新日期：2015-01-01 00:00:00

abstract：Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...

journal_title：Journal of diabetes research

authors： Eilander MMA,Snoek FJ,Rotteveel J,Aanstoot HJ,Bakker-van Waarde WM,Houdijk ECAM,Nuboer R,Winterdijk P,de Wit M

更新日期：2017-01-01 00:00:00

abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...

journal_title：Journal of diabetes research

authors： Blindbæk SL,Torp TL,Lundberg K,Soelberg K,Vergmann AS,Poulsen CD,Frydkjaer-Olsen U,Broe R,Rasmussen ML,Wied J,Lind M,Vestergaard AH,Peto T,Grauslund J

更新日期：2017-01-01 00:00:00

abstract：:Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...

journal_title：Journal of diabetes research

authors： Anbar M,Ammar H,Mahmoud RA

更新日期：2016-01-01 00:00:00

abstract：:T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

journal_title：Journal of diabetes research

authors： Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

更新日期：2015-01-01 00:00:00

abstract：:Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...

journal_title：Journal of diabetes research

authors： Geragotou T,Jainandunsing S,Özcan B,de Rooij FW,Kokkinos A,Tentolouris N,Sijbrands EJ

更新日期：2016-01-01 00:00:00

abstract：:Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...

journal_title：Journal of diabetes research

authors： Deeb A,Yousef H,Abdelrahman L,Tomy M,Suliman S,Attia S,Al Suwaidi H

更新日期：2016-01-01 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00

abstract：:Exercise is a cornerstone therapy for chronic diseases related to multiorgan insulin resistance. However, not all individuals show the anticipated improvement in insulin sensitivity following exercise and these individuals are considered exercise resistant. Caloric restriction is an approach to enhance the effect of e...

journal_title：Journal of diabetes research

authors： Gaitan JM,Weltman A,Malin SK

更新日期：2017-01-01 00:00:00