Abstract：
BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the jejunum in response to incrementally increasing concentrations of KCl was comparable in ob/ob females and lean controls regardless of a genistein-diet. There were no changes in the wall thickness measured. We assessed the number of clusters of AChR in the jejunum wall; AChR were decreased by 48% in ob/ob mice versus leans, and the genistein diet reversed this. In utilizing a video-imaging system to evaluate gastrointestinal motility, we determined that the distance between consecutive contractile events was significantly increased by 1.87-fold in ob/ob mice versus leans, and the genistein diet was without effect. CONCLUSIONS:These data suggest that slowed intestinal transit in the diabetic ob/ob mouse may be due in part to decreased AChR and decreased contraction events occurring per unit time. A genistein diet rescues the number of AChR to levels of leans yet did not change the number of contractile events. Feeding ob/ob mice a genistein-rich diet has potential therapeutic benefits towards improving the debilitating diabetes-related gastrointestinal dysfunction.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Schacht S,Masood F,Catmull S,Dolan R,Altabtabaee R,Grow W,Al-Nakkash Ldoi
10.1155/2017/3568146subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3568146eissn
2314-6745issn
2314-6753journal_volume
2017pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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