Abstract：
:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1 : 2) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), P = 0.02] and healthy controls [0.249 (0.049, 1.234), P = 0.019]. The area under the curve of the receiver operating characteristic curve for miR-122 to discriminate HNF1A-DM and T2DM was 0.687 (95% CI: 0.52-0.86, P = 0.07). There was no difference in serum miR-122 among HNF1A-DM, GCK-DM, MDM, and T1DM patients. Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji Ldoi
10.1155/2018/7842064subject
Has Abstractpub_date
2018-08-01 00:00:00pages
7842064eissn
2314-6745issn
2314-6753journal_volume
2018pub_type
杂志文章abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/379287
更新日期：2015-01-01 00:00:00
abstract：:The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/921274
更新日期：2015-01-01 00:00:00
abstract：:We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title：Journal of diabetes research
pub_type： 杂志文章,随机对照试验
doi：10.1155/2016/5027356
更新日期：2016-01-01 00:00:00
abstract：Objective:To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP. Methods:Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeti...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/2789209
更新日期：2020-03-09 00:00:00
abstract：:Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/2860780
更新日期：2016-01-01 00:00:00
abstract：Objective:The objective of this study is to investigate the relationship between time in range (TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (T2DM). Methods:A total of 349 individuals with T2DM were enrolled in this...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/5817074
更新日期：2020-02-06 00:00:00
abstract：Aim:To evaluate the influence of metabolic parameters and the treatment method in children with type 1 diabetes (T1D) on the optical coherence tomography angiography (OCTA) results as early markers of diabetic retinopathy (DR). Material and Methods. This prospective study enrolled 175 consecutive children with T1D. OCT...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/4742952
更新日期：2020-11-18 00:00:00
abstract：:Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2015/948417
更新日期：2015-01-01 00:00:00
abstract：:Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/5703652
更新日期：2018-10-14 00:00:00
abstract：:The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2016/4270301
更新日期：2016-01-01 00:00:00
abstract：Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/8623560
更新日期：2018-03-20 00:00:00
abstract：:Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/7319047
更新日期：2016-01-01 00:00:00
abstract：:Diabetic retinopathy (DR) is a severe sight-threatening complication of diabetes mellitus. Retinal laser photocoagulation, antivascular endothelial growth factors, steroid therapy, and pars plana vitrectomy are now used extensively to treat advanced stages of diabetic retinopathy. Currently, diagnostic devices like ul...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2016/1753584
更新日期：2016-01-01 00:00:00
abstract：:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...
journal_title：Journal of diabetes research
pub_type： 杂志文章,meta分析,评审
doi：10.1155/2016/5928726
更新日期：2016-01-01 00:00:00
abstract：:Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinop...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2013/432659
更新日期：2013-01-01 00:00:00
abstract：:Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/6368780
更新日期：2017-01-01 00:00:00
abstract：:Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/2358321
更新日期：2016-01-01 00:00:00
abstract：Background:In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective:To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods:Using a large multicentre database, longitudinal data from ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/8615769
更新日期：2017-01-01 00:00:00
abstract：AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2014/128014
更新日期：2014-01-01 00:00:00
abstract：:Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/9286303
更新日期：2016-01-01 00:00:00
abstract：:The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/1031367
更新日期：2018-06-27 00:00:00
abstract：Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...
journal_title：Journal of diabetes research
pub_type： 杂志文章,随机对照试验
doi：10.1155/2019/5634030
更新日期：2019-11-22 00:00:00
abstract：:The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2018/2974304
更新日期：2018-04-10 00:00:00
abstract：:The aim of the current study was to provide updated time-path equations for risk factors of type-2-diabetes-related cardiovascular complications for application in risk calculators and health economic models. Observational data from the Swedish National Diabetes Register were analysed using Generalized Method of Momen...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2013/241347
更新日期：2013-01-01 00:00:00
abstract：:Most patients with type 2 diabetes (T2D) have suboptimal adherence to recommended diet, physical activity, and/or medication. Current approaches to improve health behaviors in T2D have been variably effective, and successful interventions are often complex and intensive. It is therefore vital to develop interventions ...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2015/428349
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Previous studies indicated an association between behavior problems (internalizing, externalizing) and glycemic control (HbA1c) in youth with type 1 diabetes (T1D). The aim of this study is to examine if this association is mediated by self-confidence and mismanagement of diabetes. METHODS:Problem behavio...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/3159103
更新日期：2016-01-01 00:00:00
abstract：:The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/4989847
更新日期：2017-01-01 00:00:00
abstract：:Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is uncertain which pathway has the most implication on the disease. Changes in the expression of an entire pathway might be more important for disease pathogenesis than changes in the expression of individual genes. To ident...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2014/237535
更新日期：2014-01-01 00:00:00
abstract：Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/1462064
更新日期：2017-01-01 00:00:00
abstract：:T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/561353
更新日期：2015-01-01 00:00:00
