Abstract:
:The aim of the current study was to provide updated time-path equations for risk factors of type-2-diabetes-related cardiovascular complications for application in risk calculators and health economic models. Observational data from the Swedish National Diabetes Register were analysed using Generalized Method of Moments estimation for dynamic panel models (N = 5,043, aged 25-70 years at diagnosis in 2001-2004). Validation was performed using persons diagnosed in 2005 (n = 414). Results were compared with the UKPDS outcome model. The value of the risk factor in the previous year was the main predictor of the current value of the risk factor. People with high (low) values of risk factor in the year of diagnosis experienced a decreasing (increasing) trend over time. BMI was associated with elevations in all risk factors, while older age at diagnosis and being female generally corresponded to lower levels of risk factors. Updated time-path equations predicted risk factors more precisely than UKPDS outcome model equations in a Swedish population. Findings indicate new time paths for cardiovascular risk factors in the post-UKPDS era. The validation analysis confirmed the importance of updating the equations as new data become available; otherwise, the results of health economic analyses may be biased.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Ahmad Kiadaliri A,Clarke PM,Gerdtham UG,Nilsson P,Eliasson B,Gudbjörnsdottir S,Steen Carlsson Kdoi
10.1155/2013/241347subject
Has Abstractpub_date
2013-01-01 00:00:00pages
241347eissn
2314-6745issn
2314-6753journal_volume
2013pub_type
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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abstract::Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract:Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2018-03-20 00:00:00
abstract:INTRODUCTION:Previous studies indicated an association between behavior problems (internalizing, externalizing) and glycemic control (HbA1c) in youth with type 1 diabetes (T1D). The aim of this study is to examine if this association is mediated by self-confidence and mismanagement of diabetes. METHODS:Problem behavio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6368780
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/7526919
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2019-12-17 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/5817074
更新日期:2020-02-06 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6549242
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
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更新日期:2016-01-01 00:00:00
abstract::It is understood that intrauterine hyperglycemia increases the risk of obesity and diabetes in offspring of consecutive generations but its mechanisms remain obscure. This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transg...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/6320839
更新日期:2019-09-12 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2016/6194750
更新日期:2016-01-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8546423
更新日期:2018-04-04 00:00:00
abstract:OBJECTIVE:Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. METHODS:Streptozotocin- (STZ-) induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS), PGE2, endotheli...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8541520
更新日期:2016-01-01 00:00:00
abstract::Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1314864
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5173926
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2019-02-21 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/3641516
更新日期:2018-07-17 00:00:00
abstract:AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9582793
更新日期:2016-01-01 00:00:00
abstract::Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2641248
更新日期:2016-01-01 00:00:00
abstract::Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485759
更新日期:2015-01-01 00:00:00
abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/561353
更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/5904264
更新日期:2019-07-07 00:00:00
abstract:Background:Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. Aim:To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial ve...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/3159798
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major. However, this led to an increased risk of developing impaired glucose tolerance or diabetes. In this study we analyzed variables associated with the occurrence of impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1401829
更新日期:2016-01-01 00:00:00