Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.

abstract：Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...

journal_title：Journal of diabetes research

authors： Hohendorff J,Drozdz A,Borys S,Ludwig-Slomczynska AH,Kiec-Wilk B,Stepien EL,Malecki MT

更新日期：2019-10-28 00:00:00

abstract：:Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable...

journal_title：Journal of diabetes research

authors： Sifuentes-Franco S,Pacheco-Moisés FP,Rodríguez-Carrizalez AD,Miranda-Díaz AG

更新日期：2017-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...

journal_title：Journal of diabetes research

authors： Zhu YX,Zhang ML,Zhong Y,Wang C,Jia WP

更新日期：2016-01-01 00:00:00

abstract：AIM:To evaluate an agreement in identifying dysglycemia between fasting plasma glucose (FPG) and the 2 hr postprandial glucose tolerance test (OGTT) in a population with high risk of diabetes. METHODS:A total of 6,884 individuals aged 35-65 years recruited for a community-based diabetes prevention program were tested ...

journal_title：Journal of diabetes research

authors： Aekplakorn W,Tantayotai V,Numsangkul S,Sripho W,Tatsato N,Burapasiriwat T,Pipatsart R,Sansom P,Luckanajantachote P,Chawarokorn P,Thanonghan A,Lakhamkaew W,Mungkung A,Boonkean R,Chantapoon C,Kungsri M,Luanseng K,Chaiyaji

更新日期：2015-01-01 00:00:00

abstract：:The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...

journal_title：Journal of diabetes research

authors： Babaya N,Ueda H,Noso S,Hiromine Y,Nojima K,Itoi-Babaya M,Kobayashi M,Fujisawa T,Ikegami H

更新日期：2013-01-01 00:00:00

abstract：Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...

journal_title：Journal of diabetes research

authors： Zhu H,Zhu X,Lin H,Liu D,Dai Y,Su X,Li L

更新日期：2020-03-23 00:00:00

abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...

journal_title：Journal of diabetes research

authors： Blindbæk SL,Torp TL,Lundberg K,Soelberg K,Vergmann AS,Poulsen CD,Frydkjaer-Olsen U,Broe R,Rasmussen ML,Wied J,Lind M,Vestergaard AH,Peto T,Grauslund J

更新日期：2017-01-01 00:00:00

abstract：Background:Diabetes mellitus is a widely diffused chronic condition which impacts on several aspects of patients' lives. In the current clinical practice, the implementation in the clinical routine of monitoring systems of patients' outcomes has led to an increased generation and use of several measures for the assessm...

journal_title：Journal of diabetes research

authors： Palamenghi L,Carlucci MM,Graffigna G

更新日期：2020-05-20 00:00:00

abstract：:Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...

journal_title：Journal of diabetes research

authors： Berhane F,Fite A,Daboul N,Al-Janabi W,Msallaty Z,Caruso M,Lewis MK,Yi Z,Diamond MP,Abou-Samra AB,Seyoum B

更新日期：2015-01-01 00:00:00

abstract：:Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...

journal_title：Journal of diabetes research

authors： Samczuk P,Ciborowski M,Kretowski A

更新日期：2018-03-11 00:00:00

abstract：BACKGROUND:Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS:We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retino...

journal_title：Journal of diabetes research

authors： Alam U,Amjad Y,Chan AW,Asghar O,Petropoulos IN,Malik RA

更新日期：2016-01-01 00:00:00

abstract：:Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...

journal_title：Journal of diabetes research

authors： Hivelin C,Béraud-Dufour S,Devader C,Abderrahmani A,Moreno S,Moha Ou Maati H,Djillani A,Heurteaux C,Borsotto M,Mazella J,Coppola T

更新日期：2016-01-01 00:00:00

abstract：:Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...

journal_title：Journal of diabetes research

authors： Han LP,Li CJ,Sun B,Xie Y,Guan Y,Ma ZJ,Chen LM

更新日期：2016-01-01 00:00:00

abstract：Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...

journal_title：Journal of diabetes research

authors： Abdella NA,Mojiminiyi OA

更新日期：2018-05-20 00:00:00

abstract：:The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1 α ) in this condition. Although 6 h after LPS in...

journal_title：Journal of diabetes research

authors： Ortega A,Fernández A,Arenas MI,López-Luna P,Muñóz-Moreno C,Arribas I,Olea N,García-Bermejo L,Lucio-Cazana J,Bosch RJ

更新日期：2013-01-01 00:00:00

abstract：:Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...

journal_title：Journal of diabetes research

authors： Afanasiev SA,Kondratieva DS,Rebrova TY,Batalov RE,Popov SV

更新日期：2016-01-01 00:00:00

abstract：:We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...

journal_title：Journal of diabetes research

authors： Fotiou P,Raptis A,Apergis G,Dimitriadis G,Vergados I,Theodossiadis P

更新日期：2014-01-01 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：:Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...

journal_title：Journal of diabetes research

authors： Leontovich AA,Intine RV,Sarras MP Jr

更新日期：2016-01-01 00:00:00

abstract：:Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the reti...

journal_title：Journal of diabetes research

authors： Miao X,Sun W,Miao L,Fu Y,Wang Y,Su G,Liu Q

更新日期：2013-01-01 00:00:00

abstract：:Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

journal_title：Journal of diabetes research

authors： Aravindhan V,Madhumitha H

更新日期：2016-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....

journal_title：Journal of diabetes research

authors： Huang R,Abdelmoneim SS,Nhola LF,Mulvagh SL

更新日期：2014-01-01 00:00:00

abstract：:Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary ...

journal_title：Journal of diabetes research

authors： Leyco T,Ryanputra D,Peh R,Ponce A,Khoo CM

更新日期：2017-01-01 00:00:00

abstract：:We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...

journal_title：Journal of diabetes research

authors： Gu PY,Kang DM,Wang WD,Chen Y,Zhao ZH,Zheng H,Ye SD

更新日期：2013-01-01 00:00:00

abstract：:In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...

journal_title：Journal of diabetes research

authors： Rodriguez-Brotons A,Bietiger W,Peronet C,Magisson J,Sookhareea C,Langlois A,Mura C,Jeandidier N,Pinget M,Sigrist S,Maillard E

更新日期：2016-01-01 00:00:00

abstract：:The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...

journal_title：Journal of diabetes research

authors： Bertinat R,Westermeier F,Silva P,Gatica R,Oliveira JM,Nualart F,Gomis R,Yáñez AJ

更新日期：2018-05-29 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...

journal_title：Journal of diabetes research

authors： Röhling M,Herder C,Stemper T,Müssig K

更新日期：2016-01-01 00:00:00

abstract：:Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...

journal_title：Journal of diabetes research

authors： Dahan I,Farber E,Thauho N,Nakhoul N,Francis A,Awawde M,Levy AP,Kim-Shapiro DB,Basu S,Nakhoul F

更新日期：2015-01-01 00:00:00