Abstract:
:Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with hepatic steatosis and insulin sensitivity. Here, we evaluated the expression levels of FSP27/CIDEC and LSDP5 and the regulation of these proteins by consumption of a high-fat diet (HFD) or administration of PPAR agonists. Mice with diet-induced obesity were treated with the PPARγ or PPARα agonist, pioglitazone or fenofibrate, respectively. Liver tissues from db/db diabetic mice and human were also collected. Interestingly, FSP27/CIEDC was expressed in mouse and human livers and was upregulated in obese C57BL/6J mice. Fenofibrate treatment decreased hepatic triglyceride (TG) content and FSP27/CIDEC protein expression in mice fed an HFD diet. In mice, LSDP5 was not detected, even in the context of insulin resistance or treatment with PPAR agonists. However, LSDP5 was highly expressed in humans, with elevated expression observed in the fatty liver. We concluded that fenofibrate greatly decreased hepatic TG content and FSP27/CIDEC protein expression in mice fed an HFD, suggesting a potential regulatory role for fenofibrate in the amelioration of hepatic steatosis.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Zhu YX,Zhang ML,Zhong Y,Wang C,Jia WPdoi
10.1155/2016/8315454subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8315454eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-23 00:00:00
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journal_title:Journal of diabetes research
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of diabetes research
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