Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats.

abstract：:Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or ...

journal_title：Journal of diabetes research

authors： Axelgaard E,Østergaard JA,Thiel S,Hansen TK

更新日期：2017-01-01 00:00:00

abstract：AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...

journal_title：Journal of diabetes research

authors： Ziegler C,Liberman A,Nimri R,Muller I,Klemenčič S,Bratina N,Bläsig S,Remus K,Phillip M,Battelino T,Kordonouri O,Danne T,Lange K

更新日期：2015-01-01 00:00:00

abstract：Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...

journal_title：Journal of diabetes research

authors： Zhao X,Yu X,Zhang X

更新日期：2019-11-22 00:00:00

abstract：:Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...

journal_title：Journal of diabetes research

authors： Lee YS,Lee EK,Oh HH,Choi CS,Kim S,Jun HS

更新日期：2014-01-01 00:00:00

abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

journal_title：Journal of diabetes research

authors： Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

更新日期：2016-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...

journal_title：Journal of diabetes research

authors： Szypowska A,Ramotowska A,Grzechnik-Gryziak M,Szypowski W,Pasierb A,Piechowiak K

更新日期：2016-01-01 00:00:00

abstract：:T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

journal_title：Journal of diabetes research

authors： Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

更新日期：2015-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a severe sight-threatening complication of diabetes mellitus. Retinal laser photocoagulation, antivascular endothelial growth factors, steroid therapy, and pars plana vitrectomy are now used extensively to treat advanced stages of diabetic retinopathy. Currently, diagnostic devices like ul...

journal_title：Journal of diabetes research

authors： Park YG,Roh YJ

更新日期：2016-01-01 00:00:00

abstract：Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

journal_title：Journal of diabetes research

authors： Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

更新日期：2020-12-02 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and in...

journal_title：Journal of diabetes research

authors： Tanase DM,Gosav EM,Costea CF,Ciocoiu M,Lacatusu CM,Maranduca MA,Ouatu A,Floria M

更新日期：2020-07-31 00:00:00

abstract：:Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...

journal_title：Journal of diabetes research

authors： McEneny J,Daniels JA,McGowan A,Gunness A,Moore K,Stevenson M,Young IS,Gibney J

更新日期：2015-01-01 00:00:00

abstract：:Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...

journal_title：Journal of diabetes research

authors： Watanabe A,Noguchi H,Oe M,Sanada H,Mori T

更新日期：2017-01-01 00:00:00

abstract：:Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

journal_title：Journal of diabetes research

authors： Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

更新日期：2017-01-01 00:00:00

abstract：Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...

journal_title：Journal of diabetes research

authors： Yang S,Lin R,Si L,Li Z,Jian W,Yu Q,Jia Y

更新日期：2019-12-28 00:00:00

abstract：:This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...

journal_title：Journal of diabetes research

authors： Wang Z,Shen XH,Feng WM,Ye GF,Qiu W,Li B

更新日期：2016-01-01 00:00:00

abstract：:Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...

journal_title：Journal of diabetes research

authors： Sha H,Zhao D,Tong X,Gregersen H,Zhao J

更新日期：2016-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...

journal_title：Journal of diabetes research

authors： Simó-Servat O,Simó R,Hernández C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...

journal_title：Journal of diabetes research

authors： Gu Y,Wang Y,Li P,Wei H,Chen L,Liu Q,Liu Y,Yang Q,Cheng X,He L,Wei L,Zhu Z,Chen Y,Wang F,Shi X,Cheng Y,Wei Y,Yu J,Gong C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. METHODS:TIPE2 expression was measured b...

journal_title：Journal of diabetes research

authors： Liu Y,Wang X,Zhao Y,Zhao P,Wang L,Zhai Q,Zhang X,Tian W,Xiang X,Li T

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

journal_title：Journal of diabetes research

authors： Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

更新日期：2014-01-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...

journal_title：Journal of diabetes research

authors： Shuhong Z,Hongjun L,Bo C,Li X,Bingyin S

更新日期：2013-01-01 00:00:00

abstract：:The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four...

journal_title：Journal of diabetes research

authors： Vindeirinho J,Santiago AR,Cavadas C,Ambrósio AF,Santos PF

更新日期：2016-01-01 00:00:00

abstract：:Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is uncertain which pathway has the most implication on the disease. Changes in the expression of an entire pathway might be more important for disease pathogenesis than changes in the expression of individual genes. To ident...

journal_title：Journal of diabetes research

authors： Taneera J,Storm P,Groop L

更新日期：2014-01-01 00:00:00

abstract：:The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important feat...

journal_title：Journal of diabetes research

authors： Eken SM,Jin H,Chernogubova E,Maegdefessel L

更新日期：2013-01-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the r...

journal_title：Journal of diabetes research

authors： Yousif MH,Makki B,El-Hashim AZ,Akhtar S,Benter IF

更新日期：2014-01-01 00:00:00

abstract：:Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...

journal_title：Journal of diabetes research

authors： Han LP,Li CJ,Sun B,Xie Y,Guan Y,Ma ZJ,Chen LM

更新日期：2016-01-01 00:00:00

abstract：:Sub-Saharan Africa (SSA) continues to have the highest diabetes-related mortality rate in the world. While there exists a multitude of health system barriers driving poor diabetes control, rural facilities particularly in SSA lack access to proper monitoring of glucose and other key biologic tests. At best, most of th...

journal_title：Journal of diabetes research

authors： Park PH,Pastakia SD

更新日期：2018-02-26 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AE...

journal_title：Journal of diabetes research

authors： Blumenthal JB,Gitterman A,Ryan AS,Prior SJ

更新日期：2017-01-01 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00