Abstract:
:The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1 α ) in this condition. Although 6 h after LPS injection all mice developed a decrease in renal function, proteinuric diabetic mice showed a better recovery of this parameter throughout the study (72 h). Both HIF-1 α and vascular endothelium growth factor (VEGF) were found to be upregulated in diabetic mice. After LPS injection, all animals showed an upregulation of these factors, although it was higher in the diabetic group. Glycated albumin (GA) was found to upregulate HIF-1 α in HK-2 cells, which resulted in increased production of VEGF. Interestingly, LPS cooperated with GA to induce HIF-1 α upregulation. In conclusion, diabetic mice display a better recovery of AKI after experimental endotoxemia. Moreover, these animals showed an increased expression of both HIF-1 α and VEGF that was reproduced by incubating renal cells with GA. Since VEGF is considered a survival factor for tubular cells, our findings suggest that diabetes displays HIF-1 α upregulation that might function as a "precondition state" offering protection from endotoxic AKI.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Ortega A,Fernández A,Arenas MI,López-Luna P,Muñóz-Moreno C,Arribas I,Olea N,García-Bermejo L,Lucio-Cazana J,Bosch RJdoi
10.1155/2013/254529subject
Has Abstractpub_date
2013-01-01 00:00:00pages
254529eissn
2314-6745issn
2314-6753journal_volume
2013pub_type
杂志文章abstract::Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. A...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/2879249
更新日期:2017-01-01 00:00:00
abstract::Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8573817
更新日期:2020-06-03 00:00:00
abstract::The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/4270301
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8839376
更新日期:2020-12-15 00:00:00
abstract::We investigated effects on glucose and lipid metabolism in combination of JTT-130, a novel intestine-specific microsomal triglyceride transfer protein (MTP) inhibitor, and pioglitazone, peroxisome proliferator-activated receptor (PPAR) γ agonist. Male Zucker diabetic fatty rats were divided into 4 groups: control grou...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/890639
更新日期:2014-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/102054
更新日期:2015-01-01 00:00:00
abstract::Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5703652
更新日期:2018-10-14 00:00:00
abstract::To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of t...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9804708
更新日期:2019-11-04 00:00:00
abstract::To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8503754
更新日期:2017-01-01 00:00:00
abstract:Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8454078
更新日期:2018-09-02 00:00:00
abstract::The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4989847
更新日期:2017-01-01 00:00:00
abstract:Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1756798
更新日期:2019-10-28 00:00:00
abstract:AIMS:Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS:Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/972431
更新日期:2014-01-01 00:00:00
abstract:Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8842651
更新日期:2020-11-11 00:00:00
abstract::The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important feat...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2013/834727
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Previous studies indicated an association between behavior problems (internalizing, externalizing) and glycemic control (HbA1c) in youth with type 1 diabetes (T1D). The aim of this study is to examine if this association is mediated by self-confidence and mismanagement of diabetes. METHODS:Problem behavio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3159103
更新日期:2016-01-01 00:00:00
abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/851378
更新日期:2014-01-01 00:00:00
abstract::The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/1031367
更新日期:2018-06-27 00:00:00
abstract::We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3201534
更新日期:2016-01-01 00:00:00
abstract::Background. The aim of this study was to validate the impact of type 2 diabetes (T2D) on the platelet reactivity in patients with acute ST elevation myocardial infarction (STEMI) treated with adenosine diphosphate (ADP) receptor blockers. Methods. A pilot prospective study was performed. Totally 67 patients were enrol...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2909436
更新日期:2016-01-01 00:00:00
abstract::To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/243518
更新日期:2014-01-01 00:00:00
abstract::The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/2974304
更新日期:2018-04-10 00:00:00
abstract:OBJECTIVE:To evaluate the effect of onsite screening with a nonmydriatic, digital fundus camera for diabetic retinopathy (DR) at a diabetes outpatient clinic. RESEARCH DESIGN AND METHODS:This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for mic...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4101890
更新日期:2016-01-01 00:00:00
abstract::More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2013/906590
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. The medical records of 21 type 2 diabetic patients who used a SGLT2i and 71 patients with sulfonylurea (control) were reviewed...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6807219
更新日期:2018-12-05 00:00:00
abstract::Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5350616
更新日期:2017-01-01 00:00:00
abstract::Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2548689
更新日期:2016-01-01 00:00:00
abstract:Introduction:The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). Methods:Placental tissues from pregnant women with GDM (n = 17) and normal healthy pregnant women (n = 16) were c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1963178
更新日期:2019-10-20 00:00:00
abstract::Oxidative stress is enhanced by various mechanisms. Serum oxidized low-density lipoprotein (LDL) is a useful prognostic marker in diabetic patients with coronary artery disease. To examine the effects of Theracurmin®, a highly absorbable curcumin preparation, on glucose tolerance, adipocytokines, and oxidized LDL, we ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/8208237
更新日期:2019-11-23 00:00:00