Combination therapy of an intestine-specific inhibitor of microsomal triglyceride transfer protein and peroxisome proliferator-activated receptor γ agonist in diabetic rat.

Abstract:

:We investigated effects on glucose and lipid metabolism in combination of JTT-130, a novel intestine-specific microsomal triglyceride transfer protein (MTP) inhibitor, and pioglitazone, peroxisome proliferator-activated receptor (PPAR) γ agonist. Male Zucker diabetic fatty rats were divided into 4 groups: control group, JTT-130 treatment group, pioglitazone treatment group, and combination group. The Zucker diabetic fatty rats were fed a regular powdered diet with JTT-130 and/or pioglitazone as a food admixture for 6 weeks. Effects on glucose and lipid metabolism were compared mainly between JTT-130 treatment group and combination group. JTT-130 treatment showed good glycemic control, while the plasma glucose and glycated hemoglobin levels in combination group were significantly decreased as compared with those JTT-130 treatment group. The reduction in the plasma triglyceride and free fatty acid levels in combination group was higher than that in JTT-130 treatment group, and glucose utilization was significantly elevated in adipose tissues. In Zucker diabetic fatty rats, combination treatment of JTT-130 and pioglitazone showed better glycemic control and a strong hypolipidemic action with an enhancement of insulin sensitivity. Combination therapy of MTP inhibitor and PPAR γ agonist might be more useful in the treatment of type 2 diabetes accompanied with obesity and insulin resistance.

journal_name

J Diabetes Res

authors

Sakata S,Mera Y,Kuroki Y,Nashida R,Kakutani M,Ohta T

doi

10.1155/2014/890639

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

890639

eissn

2314-6745

issn

2314-6753

journal_volume

2014

pub_type

杂志文章
  • Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats.

    abstract::We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/3201534

    authors: Moriya C,Satoh H

    更新日期:2016-01-01 00:00:00

  • The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain.

    abstract::Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, sing...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/8294805

    authors: Al-Saber F,Aldosari W,Alselaiti M,Khalfan H,Kaladari A,Khan G,Harb G,Rehani R,Kudo S,Koda A,Tanaka T,Nakajima M,Darwish A

    更新日期:2016-01-01 00:00:00

  • Effect of Dapagliflozin on Glycemic Variability in Patients with Type 2 Diabetes under Insulin Glargine Combined with Other Oral Hypoglycemic Drugs.

    abstract:Aim:To evaluate the effect of an inhibitor of sodium-glucose cotransporter 2 (SGLT-2 inhibitor, dapagliflozin) on glycemic variability in type 2 diabetes mellitus (T2D) under insulin glargine combined with oral hypoglycemic drugs, using a continuous glucose monitoring system (CGMS). Methods:This prospective, self-cont...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/6666403

    authors: Luo M,Kong X,Wang H,Zhai X,Cai T,Ding B,Hu Y,Jing T,Su X,Li H,Ma J

    更新日期:2020-11-24 00:00:00

  • The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

    abstract::Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/5928726

    authors: Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

    更新日期:2016-01-01 00:00:00

  • Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus.

    abstract:AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/128014

    authors: Liu F,Yang Q,Gao N,Liu F,Chen S

    更新日期:2014-01-01 00:00:00

  • The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart.

    abstract:Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/8454078

    authors: Howarth FC,Qureshi MA,Jayaprakash P,Parekh K,Oz M,Dobrzynski H,Adrian TE

    更新日期:2018-09-02 00:00:00

  • Comparison of Machine Learning Methods and Conventional Logistic Regressions for Predicting Gestational Diabetes Using Routine Clinical Data: A Retrospective Cohort Study.

    abstract:Background:Gestational diabetes mellitus (GDM) contributes to adverse pregnancy and birth outcomes. In recent decades, extensive research has been devoted to the early prediction of GDM by various methods. Machine learning methods are flexible prediction algorithms with potential advantages over conventional regression...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/4168340

    authors: Ye Y,Xiong Y,Zhou Q,Wu J,Li X,Xiao X

    更新日期:2020-06-12 00:00:00

  • Dynamic Expression of HDAC3 in db/db Mouse RGCs and Its Relationship with Apoptosis and Autophagy.

    abstract:Background:Diabetic retinopathy (DR) is a severe complication of diabetes mellitus. DR is considered as a neurovascular disease. Retinal ganglion cell (RGC) loss plays an important role in the vision function disorder of diabetic patients. Histone deacetylase3 (HDAC3) is closely related to injury repair and nerve regen...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/6086780

    authors: Fu Y,Wang Y,Gao X,Li H,Yuan Y

    更新日期:2020-03-01 00:00:00

  • Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

    abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/1632061

    authors: Park BK,Lee EA,Kim HY,Lee JC,Kim KS,Jeong WH,Kim KY,Ku BJ,Rhee SD

    更新日期:2016-01-01 00:00:00

  • Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.

    abstract::Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the r...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/142154

    authors: Yousif MH,Makki B,El-Hashim AZ,Akhtar S,Benter IF

    更新日期:2014-01-01 00:00:00

  • Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients.

    abstract::Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,多中心研究

    doi:10.1155/2015/613860

    authors: Dahan I,Farber E,Thauho N,Nakhoul N,Francis A,Awawde M,Levy AP,Kim-Shapiro DB,Basu S,Nakhoul F

    更新日期:2015-01-01 00:00:00

  • Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside.

    abstract::The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2017/2562759

    authors: Blindbæk SL,Torp TL,Lundberg K,Soelberg K,Vergmann AS,Poulsen CD,Frydkjaer-Olsen U,Broe R,Rasmussen ML,Wied J,Lind M,Vestergaard AH,Peto T,Grauslund J

    更新日期:2017-01-01 00:00:00

  • The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes.

    abstract:Aim:To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. Methods:One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD1...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/6549242

    authors: Kawarabayashi R,Motoyama K,Nakamura M,Yamazaki Y,Morioka T,Mori K,Fukumoto S,Imanishi Y,Shioi A,Shoji T,Emoto M,Inaba M

    更新日期:2017-01-01 00:00:00

  • Influence of Acute and Chronic Exercise on Glucose Uptake.

    abstract::Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2868652

    authors: Röhling M,Herder C,Stemper T,Müssig K

    更新日期:2016-01-01 00:00:00

  • Type 2 Diabetes in Young Females Results in Increased Serum Amyloid A and Changes to Features of High Density Lipoproteins in Both HDL2 and HDL3.

    abstract::Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/1314864

    authors: Griffiths K,Pazderska A,Ahmed M,McGowan A,Maxwell AP,McEneny J,Gibney J,McKay GJ

    更新日期:2017-01-01 00:00:00

  • Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial.

    abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/7074042

    authors: Yang S,Lin R,Si L,Li Z,Jian W,Yu Q,Jia Y

    更新日期:2019-12-28 00:00:00

  • Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway.

    abstract::Clopidogrel (INN), an oral antiplatelet drug, has been revealed to have a number of biological properties, for instance, anti-inflammation and antioxidation. Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/9128050

    authors: Yang H,Zhao P,Tian S

    更新日期:2016-01-01 00:00:00

  • The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice.

    abstract::The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/7163652

    authors: Dahan I,Thawho N,Farber E,Nakhoul N,Asleh R,Levy AP,Li YC,Ben-Izhak O,Nakhoul F

    更新日期:2018-09-03 00:00:00

  • Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice.

    abstract::Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/8391253

    authors: Zhang H,Zhao T,Li Z,Yan M,Zhao H,Zhu B,Li P

    更新日期:2017-01-01 00:00:00

  • Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia.

    abstract::In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/3615286

    authors: Rodriguez-Brotons A,Bietiger W,Peronet C,Magisson J,Sookhareea C,Langlois A,Mura C,Jeandidier N,Pinget M,Sigrist S,Maillard E

    更新日期:2016-01-01 00:00:00

  • Case Finding and Medical Treatment of Type 2 Diabetes among Different Ethnic Minority Groups: The HELIUS Study.

    abstract::Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/9896849

    authors: Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

    更新日期:2017-01-01 00:00:00

  • Longitudinal Screening for Diabetic Retinopathy in a Nationwide Screening Program: Comparing Deep Learning and Human Graders.

    abstract:Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/8839376

    authors: Limwattanayingyong J,Nganthavee V,Seresirikachorn K,Singalavanija T,Soonthornworasiri N,Ruamviboonsuk V,Rao C,Raman R,Grzybowski A,Schaekermann M,Peng LH,Webster DR,Semturs C,Krause J,Sayres R,Hersch F,Tiwari R,Liu Y,

    更新日期:2020-12-15 00:00:00

  • The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes.

    abstract:Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/8842651

    authors: Zhao X,Zhang Y,Guo R,Yu W,Zhang F,Wu F,Shang J

    更新日期:2020-11-11 00:00:00

  • Predicting Changes in Cardiovascular Risk Factors in Type 2 Diabetes in the Post-UKPDS Era: Longitudinal Analysis of the Swedish National Diabetes Register.

    abstract::The aim of the current study was to provide updated time-path equations for risk factors of type-2-diabetes-related cardiovascular complications for application in risk calculators and health economic models. Observational data from the Swedish National Diabetes Register were analysed using Generalized Method of Momen...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2013/241347

    authors: Ahmad Kiadaliri A,Clarke PM,Gerdtham UG,Nilsson P,Eliasson B,Gudbjörnsdottir S,Steen Carlsson K

    更新日期:2013-01-01 00:00:00

  • DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.

    abstract:Background:Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac fu...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/3641516

    authors: Qiao S,Mao G,Li H,Ma Z,Hong L,Zhang H,Wang C,An J

    更新日期:2018-07-17 00:00:00

  • Association between eNOS 4b/a polymorphism and the risk of diabetic retinopathy in type 2 diabetes mellitus: a meta-analysis.

    abstract::Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases an...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2014/549747

    authors: Ma ZJ,Chen R,Ren HZ,Guo X,Guo J,Chen LM

    更新日期:2014-01-01 00:00:00

  • Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation.

    abstract:Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/1390418

    authors: Wang C,Hou XX,Rui HL,Li LJ,Zhao J,Yang M,Sun LJ,Dong HR,Cheng H,Chen YP

    更新日期:2018-11-11 00:00:00

  • Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes.

    abstract:Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/4243053

    authors: Shen Y,Si Y,Lu J,Ma X,Zhang L,Mo Y,Lu W,Zhu W,Bao Y,Hu G,Zhou J

    更新日期:2020-07-21 00:00:00

  • The effect of chromium picolinate supplementation on the pancreas and macroangiopathy in type II diabetes mellitus rats.

    abstract:PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/717219

    authors: Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

    更新日期:2014-01-01 00:00:00

  • Positive Psychological Interventions for Patients with Type 2 Diabetes: Rationale, Theoretical Model, and Intervention Development.

    abstract::Most patients with type 2 diabetes (T2D) have suboptimal adherence to recommended diet, physical activity, and/or medication. Current approaches to improve health behaviors in T2D have been variably effective, and successful interventions are often complex and intensive. It is therefore vital to develop interventions ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2015/428349

    authors: Huffman JC,DuBois CM,Millstein RA,Celano CM,Wexler D

    更新日期:2015-01-01 00:00:00