Abstract:
Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial community. We aimed to explore the alteration in composition and function of the gut microbiome in T2DM patients. Methods:A total of 137 patients with diabetes and 179 age- and gender-matched healthy controls selected from the healthy people sample center in the First Affiliated Hospital of Zhengzhou University were divided into the DM group and the Con group, respectively. We collected their venous blood for laboratory tests and stool samples for 16S rRNA sequencing. The comparison between the two groups including both composition and function of the gut microbiome is presented. Results:We found that the α-diversity of bacterial taxa in the DM group had an evident decrease compared to that in the Con group. At the phylum level, the DM group had an obvious decrease of Bacteroidetes and a marked increase of Proteobacteria, Actinobacteria, and Verrucomicrobia. At the genus level, Bacteroides and Prevotella decreased the most while Escherichia-Shigella, Lachnospiraceae_incertae_sedis, Subdoligranulum, Enterococcus, and Klebsiella had different degrees of expansion in the DM group. The ROC based on 246 optimum OTUs had very high test efficiency with an AUC of 92.25% in the training set and 90.48% in the test set. As for prediction of metabolic function, the gut microbiome of DM patients was predicted to be more active in environmental information processing and human diseases but less in metabolism. Conclusion:We observed alteration of composition and function of the gut microbiome in the DM group. These changes may provide a new treatment strategy for DM patients and new research targets.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Zhao X,Zhang Y,Guo R,Yu W,Zhang F,Wu F,Shang Jdoi
10.1155/2020/8842651subject
Has Abstractpub_date
2020-11-11 00:00:00pages
8842651eissn
2314-6745issn
2314-6753journal_volume
2020pub_type
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/6270875
更新日期:2018-03-11 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8541520
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5649191
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7319047
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2860780
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pub_type: 杂志文章
doi:10.1155/2013/608923
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7074042
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pub_type: 杂志文章
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