Abstract:
:Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body weight/day) for 8 weeks. We examined hemoglobin A1c (HbA1c), blood glucose levels, food intake, and body weight. We performed glucose, insulin, and pyruvate tolerance tests and analyzed glucose production and the expression of gluconeogenesis-related genes in hepatocytes. We analyzed energy metabolism using a comprehensive animal metabolic monitoring system. SA-treated diabetic db/db mice had reduced concentrations of HbA1c and blood glucose levels. Exogenous glucose was quickly cleared in glucose tolerance tests. The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice. In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4α) mRNA. Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration. The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes. In addition, SA-treated diabetic db/db mice showed reduced energy expenditure. Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Lee YS,Lee EK,Oh HH,Choi CS,Kim S,Jun HSdoi
10.1155/2014/961732subject
Has Abstractpub_date
2014-01-01 00:00:00pages
961732eissn
2314-6745issn
2314-6753journal_volume
2014pub_type
杂志文章abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7074042
更新日期:2019-12-28 00:00:00
abstract::To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/243518
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7163652
更新日期:2018-09-03 00:00:00
abstract::We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1567405
更新日期:2016-01-01 00:00:00
abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/561353
更新日期:2015-01-01 00:00:00
abstract::Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/613860
更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3295747
更新日期:2016-01-01 00:00:00
abstract:Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/1038585
更新日期:2020-12-02 00:00:00
abstract::We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/807209
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6086780
更新日期:2020-03-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/549747
更新日期:2014-01-01 00:00:00
abstract:Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/9787839
更新日期:2020-03-23 00:00:00
abstract:Background:Diabetes mellitus is a widely diffused chronic condition which impacts on several aspects of patients' lives. In the current clinical practice, the implementation in the clinical routine of monitoring systems of patients' outcomes has led to an increased generation and use of several measures for the assessm...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/5419298
更新日期:2020-05-20 00:00:00
abstract::Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/102054
更新日期:2015-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/723190.]. ...
journal_title:Journal of diabetes research
pub_type: 已发布勘误
doi:10.1155/2017/7947401
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/9737483
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/142154
更新日期:2014-01-01 00:00:00
abstract:Objective:Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD). Even after strict control of obesity, hyperglycemia, and hypertension, some patients still progress rapidly. Previous studies suggested diabetic dyslipidemia might be one of the factors responsible for this high residual...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/3613041
更新日期:2020-09-28 00:00:00
abstract::Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/4020492
更新日期:2018-04-02 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/3641516
更新日期:2018-07-17 00:00:00
abstract:Background:Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study is aimed at assessing the relationship between perirenal fat ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6076145
更新日期:2020-06-28 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4312737
更新日期:2019-08-14 00:00:00
abstract::Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485759
更新日期:2015-01-01 00:00:00
abstract::Metabolic inflammatory damage, characterized by Toll-like receptor 4 (TLR4) signaling activation, is a major mechanism underlying lipotoxicity-induced β-cell damage. The present study is aimed at determining whether G protein-coupled receptor 4 (GPR40) agonist can improve β-cell lipotoxicity-induced damage by inhibiti...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/5487962
更新日期:2019-12-17 00:00:00
abstract:PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/717219
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8472391
更新日期:2016-01-01 00:00:00
abstract::Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8573817
更新日期:2020-06-03 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/6156217
更新日期:2016-01-01 00:00:00
abstract::Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5703652
更新日期:2018-10-14 00:00:00