Abstract:
PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats in each group). After supplementing CrPic for 15 weeks, the histopathological examination was performed by hematoxylin-eosin (HE) staining. Serum insulin and NO level were determined by radioimmunoassay and colorimetry, respectively. Serum glycosylated hemoglobin (HbA1C), adiponectin (APN), advanced glycation end products (AGES), and apelin were measured by ELISA. Real-time reverse transcription polymerase chain reaction (RT-PCR) was applied for detecting the mRNA expression of APN and apelin. RESULTS:After CrPic treatment, compared with the T2DM control group (group 2), pancreas sections stained with HE showed the completed pancreatic cells structure and no inflammatory infiltration in groups 4 and 5. In addition, the levels of serum NO and insulin were significantly increased and the serum levels of HbA1C, AGES, APN, and apelin were significantly decreased in groups 4 and 5 compared with group 2. The mRNA expression of APN and apelin in groups 4 and 5 was also recovered to the normal level. CONCLUSION:CrPic can recover the function of Β-cells and alleviate macroangiopathy in STZ-induced T2DM rats.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu Jdoi
10.1155/2014/717219subject
Has Abstractpub_date
2014-01-01 00:00:00pages
717219eissn
2314-6745issn
2314-6753journal_volume
2014pub_type
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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journal_title:Journal of diabetes research
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-11 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00