Abstract:
:Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Dahan I,Farber E,Thauho N,Nakhoul N,Francis A,Awawde M,Levy AP,Kim-Shapiro DB,Basu S,Nakhoul Fdoi
10.1155/2015/613860subject
Has Abstractpub_date
2015-01-01 00:00:00pages
613860eissn
2314-6745issn
2314-6753journal_volume
2015pub_type
杂志文章,多中心研究abstract::Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/948417
更新日期:2015-01-01 00:00:00
abstract::The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/2974304
更新日期:2018-04-10 00:00:00
abstract::We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
abstract::Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8573817
更新日期:2020-06-03 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1567405
更新日期:2016-01-01 00:00:00
abstract:Purpose:Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations....
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2019/6906278
更新日期:2019-12-14 00:00:00
abstract::To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of t...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9804708
更新日期:2019-11-04 00:00:00
abstract::The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/379287
更新日期:2015-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fi...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/846807
更新日期:2015-01-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8546423
更新日期:2018-04-04 00:00:00
abstract::Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1314864
更新日期:2017-01-01 00:00:00
abstract::We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolera...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5307523
更新日期:2017-01-01 00:00:00
abstract:Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/9626413
更新日期:2019-08-01 00:00:00
abstract:Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/9787839
更新日期:2020-03-23 00:00:00
abstract:Aim:To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. Methods:One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD1...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6549242
更新日期:2017-01-01 00:00:00
abstract:Objective:To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP. Methods:Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeti...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/2789209
更新日期:2020-03-09 00:00:00
abstract::Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6368780
更新日期:2017-01-01 00:00:00
abstract::Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9286303
更新日期:2016-01-01 00:00:00
abstract:Background:Diabetic retinopathy (DR) is a severe complication of diabetes mellitus. DR is considered as a neurovascular disease. Retinal ganglion cell (RGC) loss plays an important role in the vision function disorder of diabetic patients. Histone deacetylase3 (HDAC3) is closely related to injury repair and nerve regen...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6086780
更新日期:2020-03-01 00:00:00
abstract::Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinop...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/432659
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2017/6924637
更新日期:2017-01-01 00:00:00
abstract::Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2548689
更新日期:2016-01-01 00:00:00
abstract:Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4745389
更新日期:2020-05-15 00:00:00
abstract::Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications. We i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2029854
更新日期:2016-01-01 00:00:00
abstract::Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/102054
更新日期:2015-01-01 00:00:00
abstract::Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/2769819
更新日期:2017-01-01 00:00:00
abstract::The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1867059
更新日期:2016-01-01 00:00:00
abstract::Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AE...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1492581
更新日期:2017-01-01 00:00:00