Abstract:
Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in young male offspring and the possible underlying mechanisms. Methods:Female rats were divided into a maternal hypothyroidism (MH) group, which received water containing 0.02% 6-propyl-2-thiouracil before and during pregnancy to induce hypothyroidism, and a control group which consumed tap water. Results:Our results showed that there were no differences of islets structure between the offspring from the two groups, but glucose metabolism was impaired with higher plasma glucose concentrations at 0 and 15 min in the OGTT in 8-week-old offspring of the MH group. From birth to 8 weeks, pancreatic TRβ1 and TRβ2 mRNA level declined significantly in MH offspring, accompanied by decreased Ki67 and insulin mRNA expression. Conclusions:Maternal hypothyroidism results in impaired pancreatic insulin synthesis and pancreatic cell proliferation in neonatal offspring and subsequent glucose intolerance in young offspring, which may be related to TRβ gene downregulation in the pancreas.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Liu Z,Chen Y,Chen G,Mao X,Wei X,Li X,Xu Y,Jiang F,Wang K,Liu Cdoi
10.1155/2019/4713906subject
Has Abstractpub_date
2019-02-21 00:00:00pages
4713906eissn
2314-6745issn
2314-6753journal_volume
2019pub_type
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1155/2016/6264149
更新日期:2016-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00